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Danielle Bianchi

@daaninthelab.bsky.social

171 followers 234 following 14 posts

PhD student in the Brummelkamp lab at the Netherlands Cancer Institute. Passionate about science and sarcasm. 🏳️‍🌈

Posts Replies Media

Reposted by Danielle Bianchi

Netherlands Cancer Institute @nkinl.bsky.social · 10/07/2025

Scientists at the NKI have made a remarkable discovery: a new protein duo that can turn genes on and off. They have named this duo Zincore. Together, these proteins help other proteins bind more firmly to the DNA, allowing them to perform their functions more effectively www.nki.nl/news-events/...

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Reposted by Danielle Bianchi

Razvan Borza @rborza.bsky.social · 09/07/2025

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

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Reposted by Danielle Bianchi

Razvan Borza @rborza.bsky.social · 08/07/2025

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation.
Made in Blender with Molecular Nodes.

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Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

science.org

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

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