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Zwartlab NKI

@zwartlab.bsky.social
151 followers 114 following 5 posts

Epigenetics | hormone receptors | transcriptional regulation | hormone-driven cancers | Netherlands Cancer Institute | University of Technology Eindhoven | Oncode Institute | Cancer Core Europe |Amsterdam, The Netherlands

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Zwartlab NKI @zwartlab.bsky.social · 10/05/2025
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
pubmed.ncbi.nlm.nih.gov
Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations - PubMed
In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.
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Zwartlab NKI @zwartlab.bsky.social · 21/03/2025
Check out our latest paper! WGS on 378 metastases of patients with prostate cancer. Biggest findings: 1. Non-coding mutations converge on DNA damage repair 2. Coding mutations defer between metastatic sites, with potential implications on systemic therapy selection. pubmed.ncbi.nlm.nih.gov/40114169/
pubmed.ncbi.nlm.nih.gov
Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications - PubMed
NCT01855477.
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Zwartlab NKI @zwartlab.bsky.social · 17/02/2025
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story! www.biorxiv.org/content/10.1...
biorxiv.org
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...
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Zwartlab NKI @zwartlab.bsky.social · 13/02/2025
What do steroid hormone receptor action and DNA damage repair have in common? Check out our latest review in @cp-trendsmolecmed.bsky.social! pubmed.ncbi.nlm.nih.gov/39934021/
cell.com
The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer
Human cells potentiate highly diverse functions through tight transcriptional regulation and maintenance of genome integrity. While the DNA damage response (DDR) safeguards the genome, ligand-activate...
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Reposted by Zwartlab NKI
Mathieu Lupien @matlupien.bsky.social · 28/01/2025
🌟 Spots are limited—register now! 🌟 Join us for the 2025 Cancer Genetics and Epigenetics GRC in Tuscany, Italy, May 18–23, where global experts will present their latest breakthroughs and discuss the future of cancer research. Register today: www.grc.org/cancer-genet...
grc.org
2025 Cancer Genetics and Epigenetics Conference GRC
The 2025 Gordon Research Conference on Cancer Genetics and Epigenetics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
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Zwartlab NKI @zwartlab.bsky.social · 22/01/2025
Looking forward visiting @inem-necker.bsky.social and @goffinlab.bsky.social! Great day of talking science and meeting scientists in the beautiful city of Paris; whats not to like? 😁
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Reposted by Zwartlab NKI
Eric Small MD @ericsmall.bsky.social · 19/12/2024
I'm pleased to announce that the ASCO/Conquer Cancer Foundation Felix Feng Prostate Cancer YIA is now fully endowed and will fund a young prostate cancer investigator every year, in perpetuity. The First Felix Feng YIA recipient will be announced this spring and celebrated at ASCO's annual meeting.
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Reposted by Zwartlab NKI
Toni Choueiri, MD @drchoueiri.bsky.social · 07/01/2025
In Memory of Dr Felix Feng, our beloved friend and a giant in prostate cancer @ericsmall.bsky.social @ucsfcancer.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
In Memory of Dr. Felix Feng
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