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TJ McCorvie

@allostericstate.bsky.social
1.6K followers 1.9K following 205 posts

Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD www.recon4imd.org Views are my own.

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Reposted by TJ McCorvie
pilarcossio.bsky.social @pilarcossio.bsky.social · 5h
*Job alert*: Postdoc position at the Flatiron Institute to work on biophysical inference and cryo-EM. ❄️ 🔬Applications are welcome! apply.interfolio.com/193799
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Structura Biotechnology @structurabio.bsky.social · 8h
Are you looking for another opportunity to learn #SingleParticle #cryoEM? Instruct.SI is organizing a workshop covering cryo-EM from grid preparation to 3D reconstruction! 👀 Check out their website for more information - registration deadline October 2, 2026
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Adam Rutherford @adamrutherford.bsky.social · 29/09/2026
Do the stats for women! It’s 5.
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c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
The obvious conclusion (to me): if you have proprietary research & you upload it into the Plagiarism Nexus, it's not YOUR proprietary research anymore. Behave accordingly.
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Sholto David @sholtodavid.bsky.social · 27/09/2026
Today I'm posting a new video about a team of ophthalmology researchers in Germany who scribbled on their figures! t.co/X2U6zCw9pn
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Carl T. Bergstrom @carlbergstrom.com · 26/09/2026
Does my Speak-n-Spell feel pain when I type O-U-C-H? The jury is out. Philosophers and neuroscientists say that's fucking stupid, but I called a guy from the Center for Pretending that Household Electronics Are Sentient and he said there's no way to know for sure.
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 25/09/2026
September 25th is International #Ataxia Awareness Day PDB structures help us better understand the disease and treament options
asbmb.org
Ataxia: A symptom and a disease
It's International Ataxia Awareness Day.
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Craig Kaplan @triggerloop.bsky.social · 25/09/2026
Cryo-EM peeps are living the dream www.science.org/doi/10.1126/...
science.org
In-cell structures visualize human pre-ribosome assembly in the nucleolus
In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...
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ChimeraX @chimerax.ucsf.edu · 25/09/2026
Make natural language requests to ChimeraX with the new Pellaeon plugin developed by Yam Amir that works with many free and paid large language models. Get Pellaeon using ChimeraX menu Tools / More Tools.... cxtoolshed.rbvi.ucsf.edu/apps/chimera...
PAR1 molecular structure shown in ChimeraX using Pellaeon chat bot.
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Daniel Hurdiss @danielhurdiss.bsky.social · 25/09/2026
For anyone interested in a more accessible overview of our recent norovirus paper, Utrecht University has now published a news item about the work. www.uu.nl/en/news/mole...
uu.nl
Molecular motor may help norovirus transport its genetic material
Researchers have uncovered new details about a key norovirus protein. They provide a new framework for future research into the virus and antiviral drugs.
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Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026
thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️
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Jon Marles-Wright @jmarlesw.bsky.social · 21/09/2026
Starting off my 29th Fresher’s week with a proud supervisor moment. Congratulations to Imogen for successfully defending her PhD thesis. Thanks to Wyatt Yue and Paul James for examining and a special thanks to Dennis the support dog!
A photograph of a PhD candidate, their examiners, and supervisor.
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Daniel Hurdiss @danielhurdiss.bsky.social · 21/09/2026
Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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TJ McCorvie @allostericstate.bsky.social · 18/09/2026
Forbidden chocolate and pistachio ice cream.
Image of two 50 ml falcon tubes with two green and brown bacterial cell pellets of a GFP tagged heme protein.
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Kevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026
found at ucsf
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Janani Durairaj (Jay) @ninjani.bsky.social · 16/09/2026
The PhD and Postdoc application links are now live! Come join me at UNIL to work on deep learning for protein structure, interactions & design. pickybinders.org#open-positions
career5.successfactors.eu
Career Opportunities: PhD student position in deep learning for enzyme structure & catalysis (22980)
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Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 16/09/2026
Did some reviews and…. Why do ppl show biophysical assays without the actual data? KD values with no curves or fits. An ITC table without a single raw thermogram. You wouldn’t publish a Western without the blot, but for binding assays we just say “trust me bro”. Free the curves!!
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Sukrit Singh @sukritsingh92.bsky.social · 15/09/2026
📣 The Singh Lab opens at Fox Chase Cancer Center in Spring 2027, where I will be starting as an Assistant Professor!📣 Excited to continue studying how protein biophysics shapes drug response. I am hiring across all levels and disciplines! Apply on the "Join" page ( & spread the word!): singhlab.bio
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Twonks @twonks.bsky.social · 14/09/2026
Wow
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Twonks @twonks.bsky.social · 14/09/2026
Oh
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Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 14/09/2026
Happy to share our preprint on a subset of ZBTB BTB domains as highly efficient natural SUMO 'supersubstrates'. The work was spearheaded by a great postdoc, El Hadji Cisse, with input from other team members and in collaboration with @defossezlab.bsky.social and @ucagne.bsky.social
biorxiv.org
A new class of inherently efficient SUMOylation substrates
SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...
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Robbi Bishop-Taylor 🛰️🌏 @satellitesci.bsky.social · 11/08/2026
This is a first for me: a citation for a paper I never wrote... in a new book published by @SpringerNature.com no less! 😱 Geospatial Application of Coastal Hazards: Monitoring, Mitigation, Adaption and Prediction Springer Nature, 2026
A screenshot of Google Books, showing a citation highlighted in yellow. This citation does not exist.
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Anne Applebaum @anneapplebaum.wsocial.eu · 14/09/2026
Your regular reminder: If the Russians stop fighting, the war ends. If the Ukrainians stop fighting, their land will be occupied, their leaders will be killed, their history and language will be erased, their children will be kidnapped to serve Russia.
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Sholto David @sholtodavid.bsky.social · 13/09/2026
A new video on my YouTube Channel - This one is about a 2013 Nature Neuroscience paper with extensive image manipulation. www.youtube.com/watch?v=3R6V...
youtube.com
Image Fraud in Nature Neuroscience
YouTube video by Sholto David
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cryoEM papers @cryoempapers.bsky.social · 13/09/2026
Specimen-Dependent Sampling and Signal Limitations Govern the Effectiveness of Low-Magnification Super-Resolution in Cryo-EM www.biorxiv.org/content/10.64898/2026.09.08.750297v1 #cryoEM
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Lorna Malone @drlornamalone.bsky.social · 11/09/2026
Online registration is still open for the Wellcome–MRC in situ Cryo-ET Workshop 2026! 🦠🔬 📅 28 Sept – 02 Oct 2026 📍 @diamondlightsource.bsky.social & @astburycentre.bsky.social 💻 Hybrid stream available via Zoom 🔗Learn more and register: shorturl.at/LRihg #CryoET #CryoEM #StructuralBiology
shorturl.at
Wellcome-MRC in situ Cryo-ET Workshop 2026 - - Diamond Light Source
eBIC (Diamond light source) has partnered with the Astbury Biostructure Lab (University of Leeds), the Scottish Centre for Macromolecular Imaging (University of Glasgow), Midlands Regional Cryo-EM Fac...
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Daniel Hurdiss @danielhurdiss.bsky.social · 09/09/2026
Our first #cryoEM map from the Krios 5 recently installed at Utrecht University as part of the EMPower-funded upgrades to NeCEN. Hopefully the first of many more!
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Marcus Chown @marcuschown.bsky.social · 09/09/2026
A third of nurses and a third of doctors were born overseas. Without immigrants the NHS would collapse. You are more likely to be treated by an immigrant than to be behind one in a queue. Massive underfunding of our NHS and lack of social housing were a political choice.
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TJ McCorvie @allostericstate.bsky.social · 07/09/2026
Registration for the Northern Structural Biology Meeting 2026 is now open! A great day of cryo-EM, X-ray crystallography, integrative structural biology and protein science. Come along to share your work, meet colleagues and make new connections! #StructuralBiology #CryoEM
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Peter Kenny @pwk2024.bsky.social · 07/09/2026
Opportunity in structural biology at Concept Life Sciences (Edinburgh UK) closing: 30-Sep-2026 #StructBiol #chemsky 🧪 conceptlifesciences.peoplehr.net/Pages/JobBoa...
conceptlifesciences.peoplehr.net
Principal Scientist – Structural Biology
Concept Life Sciences seeks a Principal Scientist to lead structural biology projects, specialising in X‑ray crystallography and Cryo‑EM. The role is hands‑on, client‑focused, and involves mentoring, ...
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Magnus Bauer @kinasekid.bsky.social · 06/09/2026
AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳
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Instruct-ERIC @instruct-eric.bsky.social · 05/09/2026
EMBL Course - Autumn school on single particle cryo-EM: from sample to 3D reconstruction 📅 19 – 23 October 2026 📍 @embl.org Imaging Centre, Heidelberg, Germany 📝 Registration Open| Deadline: 13 September 2026 🔗Link below instruct-eric.org/events/embl-...
instruct-eric.org
EMBL Course - Autumn school on single particle cryo-EM: from sample to 3D reconstruction
<p>The EMBL Imaging Centre in collaboration with the Heidelberg University is offering a 5-day autumn school covering all aspects of the single particle cryo-EM workflow. The autumn school will focus…
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Kasinath-Lab @kasinath-lab.bsky.social · 04/09/2026
🚨🚨New preprint from ***Outstanding*** graduate student Jessica Song 🚨🚨 Jessica determined several cryo-EM structures (one at 2.5 Å) capturing, for the first time, protein recognition of a pUG-fold RNA & revealing how pUG-fold RNA inhibits DNMT1 activity through multiple modes. tinyurl.com/398ukze9
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cryoEM papers @cryoempapers.bsky.social · 03/09/2026
Structural Plasticity and Ligand Promiscuity of CYP3A4 Revealed by Cryo-EM www.biorxiv.org/content/10.64898/2026.09.01.748687v1 #cryoEM
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Nature Structural & Molecular Biology @natsmb.nature.com · 02/09/2026
ICYMI: New online: Molecular architecture and spatial organization of proteasomes in the human sperm nucleus
dlvr.it
Molecular architecture and spatial organization of proteasomes in the human sperm nucleus
Nature Structural & Molecular Biology, Published online: 01 September 2026; doi:10.1038/s41594-026-01870-zProteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.
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Sonya Neal @neal-lab.bsky.social · 02/09/2026
Come be my colleague!! 🎉 We’re hiring an Assistant Professor in Developmental Biology at UCSD! If you’re doing exciting work in development or regeneration, come join us!! Please spread the word and apply! apol-recruit.ucsd.edu/JPF04591
apol-recruit.ucsd.edu
Assistant Professor of Developmental Biology
University of California, San Diego is hiring. Apply now!
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cryoEM papers @cryoempapers.bsky.social · 01/09/2026
Structures of the human sodium-citrate cotransporter NaCT with and without substrates pubmed.ncbi.nlm.nih.gov/42673948/ #cryoEM
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Haselbach Lab @haselbachlab.bsky.social · 31/08/2026
Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September. 24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session. events.vbc.ac.at/imp_events/c... #cryoEM #cryoET
events.vbc.ac.at
Cryo-EM Symposium 2026
Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 27/08/2026
“Using research as an opportunity for learning-by-doing may produce seeming ‘inefficiencies,’ but that’s a feature, not a bug…the process of education is necessarily a productive struggle, and that the most important product of their education is not a GPA or a diploma but themselves“
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Instruct-ERIC @instruct-eric.bsky.social · 30/08/2026
Instruct.SI CryoEM Workshop 2026, Single Particle Analysis 📅 10 – 12 November 2026 📍 National Institute of Chemistry, Ljubljana, Slovenia. 📝 Registration Open| Deadline: 2 October 2026 🔗 instruct-eric.org/events/instr...
instruct-eric.org
Instruct.SI CryoEM Workshop 2026, Single Particle Analysis
<p>Cryo-EM Workshop on Single Particle Analysis (SPA) is based on the very positive response to the Basics of Methodological Approaches in Structural Biology workshop in 2024 and the and Instruct.SI…
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cryoEM papers @cryoempapers.bsky.social · 29/08/2026
Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging www.biorxiv.org/content/10.64898/2026.08.27.747605v1 #cryoEM
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TJ McCorvie @allostericstate.bsky.social · 27/08/2026
☹️
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Astronomer Royal for Scotland | Catherine Heymans @astroroyalscot.bsky.social · 15/08/2026
This is a pleasing factoid: the Nancy Grace Roman space telescope is the same size and weight as a T-Rex! Countdown: 15 days to launch! 🚀 AUG 30, 2026 11:26 UTC ℹ️: science.nasa.gov/mission/roma...
A sketch of a T-Rex dinosaur (big feet, tiny hands) next to a sketch of the Roman telescope.
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TJ McCorvie @allostericstate.bsky.social · 26/08/2026
It's the Wild West for trustworthy antibody validation...
static.klipy.com
Iconic Cowboy Tips Hat
ALT: Iconic Cowboy Tips Hat
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Katie Mack @astrokatie.com · 24/08/2026
Sometimes society at large rejects certain ideas because they’ve been thoroughly shown to be wrong and also because they suck and the people who espouse them suck and when someone comes around arguing those ideas should be part of some edgy modern debate we can and should shun them and move on.
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Sholto David @sholtodavid.bsky.social · 21/08/2026
www.nature.com/articles/d41...
nature.com
Sleuth identifies dozens of studies that used the wrong antibody
The case is the latest example of a scientific workhorse being misused in experiments.
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Alex Guseman @alexguseman.bsky.social · 21/08/2026
Come be my colleague! We are hiring a structural biologist. I have thoroughly enjoyed starting my career here and both department(s) are full of exceptional scientists. apol-recruit.ucsd.edu/JPF04589
apol-recruit.ucsd.edu
Assistant Professor in Structural Biochemistry
University of California, San Diego is hiring. Apply now!
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Newcastle University Structural Biology Facility @nusbf.bsky.social · 19/08/2026
Keynote announced! We're delighted to welcome Prof. Laura Spagnolo (University of Glasgow) as keynote speaker for the CCP4 Northern Structural Biology Meeting 2026 11–13 Nov | Newcastle Free to attend cc @lauraspagnolo.bsky.social #StructuralBiology #CryoEM #CCP4
nusbf.ncl.ac.uk
CCP4 Northern meeting 2026: Keynote Speaker Laura Spagnolo
CCP4 Northern meeting 2026 keynote speaker announced: Prof. Laura Spagnolo (Glasgow) will speak 11–13 Nov in Newcastle.
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