Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurable mitochondrial pathologies. Using a genome-wide C...

The official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center.

We are at an inflection point in how we support science in the U.S. New York state must invest in its science institutions and workforce.

The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.

Telomeres are specialized structures that protect the ends of linear chromosomes in eukaryotes. Research in this area has revealed that telomere maintenance is critical for stem cell function and nor…

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

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America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.

Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Nature Structural & Molecular Biology - Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

The Trump administration hobbles research and endangers the public health.

The newly configured department marshals biochemists, biophysicists and experts in protein engineering and imaging to drive discoveries in the basic mechanisms of cell function.

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

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Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...