Advanced prostate cancer remains one of the deadliest cancers in men, and current immunotherapies have shown only limited success. One reason is that tumors do not act alone: they reshape the body’s [...

In 2026, the Human Oncology and Pathogenesis Program (HOPP) celebrates 20 years of discovery, leadership, and impact in translational oncology. HOPP supports innovation and collaboration between talen...

Ladewig et al. show that distinct Foxa1 mutations reprogram chromatin, altering epithelial lineage specification. Indels promote basal-like states, whereas C-terminal truncations, Wing2 missense mutat...

Nature Genetics - Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Restoration of downstream mTOR signaling causes resistance to combined Akt and androgen receptor blockade in prostate cancer.