Reposted by Tata Kavlashvili
mtDNA deletions cause incurable diseases. Our CRISPR screen found a fix: deleting MTERF1 restores mitochondrial function, not by clearing bad genomes, but by making the healthy ones work harder. Simple Biology! New preprint 👇 @tatakavlashvili.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation
Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurable mitochondrial pathologies. Using a genome-wide C...
