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Jose M. Adrover

@adrover.bsky.social
333 followers 676 following 26 posts

Studying the cancer-cardiovascular disease interplay, with a focus on how cancer reprograms the hematopoietic and immune systems, at the Francis Crick Institute in London www.adroverlab.com

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Reposted by Jose M. Adrover
The Francis Crick Institute @crick.ac.uk · 24/09/2026
Zooming out on cancer: how it rewires our biology, from tissues to organs and whole-body systems. Researchers Caroline Hill, Ilaria Malanchi and @adrover.bsky.social are helping to unravel this vast complexity, opening up new opportunities to tackle the disease. www.crick.ac.uk/news/2026-08...
crick.ac.uk
Cancer: the bigger picture
Bold ideas and cross-disciplinary science are revealing how cancer rewires cells, tissues and whole-body systems.
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Jose M. Adrover @adrover.bsky.social · 30/06/2026
I am deeply moved and grateful to receive the Sue Eccles award from the @metastasisresearch.bsky.social, a community whose work I admire profoundly. It really belongs to my mentors; they are the ones that helped me reach this point! So this is to you @megeblad.bsky.social and @drusqui.bsky.social
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Reposted by Jose M. Adrover
Alaz Ozcan @alazozcan.bsky.social · 12/03/2026
Thrilled to welcome the wonderful @adrover.bsky.social to Zurich for our monthly SMyLe @smyle-ch.bsky.social seminar! 📅 March 24 | 16:30 📍 ETH Hönggerberg Join us to hear José present his great science! Special thanks to @syis-ecr.bsky.social for supporting this event!
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Reposted by Jose M. Adrover
The Francis Crick Institute @crick.ac.uk · 02/03/2026
Are you a clinician looking for a fully-funded postdoctoral research opportunity? Check out our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community: www.crick.ac.uk/careers-and-...
crick.ac.uk
Postdoctoral clinical fellows
Opportunities for postdoctoral clinicians to consolidate their research experience.
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Reposted by Jose M. Adrover
Caetano Reis e Sousa @reisesousalab.bsky.social · 02/01/2026
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
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Jose M. Adrover @adrover.bsky.social · 07/11/2025
I am deeply honoured to receive the Sue Eccles Early Career Investigator Award @metastasisresearch.bsky.social. Thank you for your continued support of emerging investigators in metastasis research!
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Reposted by Jose M. Adrover
Metastasis Research Society @metastasisresearch.bsky.social · 04/11/2025
🏆 MRS Sue Eccles Early Career Investigator Award: Jose M. Adrover
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Reposted by Jose M. Adrover
Metastasis Research Society @metastasisresearch.bsky.social · 03/11/2025
🚀 Two weeks to go! The ECR Meeting brings together early-career scientists driving the next wave of metastasis research. ⚡ Don’t miss: 💡 Inspiring talks from rising leaders 💬 Community-led discussions 🌍 A global metastasis community 🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o Program ➜ bit.ly/4qtpVR9
metastasis-research.org
2nd MRS Early Career Research Virtual Meeting | Metastasis Research
The 2025 MRS Early Career Research Virtual Meeting is a two day meeting aimed at engaging trainees and early career researchers from around the world and highlighting recent advances in metastasis research through keynote presentations, invited talks, panel discussions, and selected talks from abstracts. The meeting is organized and hosted by the Early Career Leadership Council (ECLC) of the MRS. Abstracts are being accepted for consideration for oral presentations. Abstract submission is open to graduate students, postdoctoral fellows, medical students, residents, clinical fellows, and researchers within 3 years of starting their own independent research group. Registration for this meeting is free for MRS Members!
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Reposted by Jose M. Adrover
Journal of Experimental Medicine @jem.org · 01/11/2025
This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/... 📘 In #Cytokines collection: rupress.org/jem/collecti... #Cytokines2025
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Jose M. Adrover @adrover.bsky.social · 16/10/2025
My lab will be recruiting a PhD student this year. Have a look and apply if it sounds interesting! adroverlab.com/open-call-fo...
adroverlab.com
Open call for a PhD student - Cancer Macroenvironment Lab
Investigating the role of neutrophils in tumour progression, microenvironment dynamics and metastatic spread Application deadline: 5th of November, 2025 Project background and description Our laborato...
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Reposted by Jose M. Adrover
The Francis Crick Institute @crick.ac.uk · 09/10/2025
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
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Reposted by Jose M. Adrover
Anna Obenauf @obenaufa.bsky.social · 09/09/2025
🔥Trio Fatale: Neutrophils, NETs and Necrosis 👉 authors.elsevier.com/a/1lk-k3qNrU... We summarized for @cp-immunity.bsky.social "Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau Congrats!
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Reposted by Jose M. Adrover
Hao Yin @haoyin.bsky.social · 07/09/2025
A new model of #TumorNecrosis👹 Tumor CXCL1➡️myeloid skewing➡️ Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️ Intratumoral vascular occlusion➡️ Pleomorphic Necrosis-to-Metastasis a role of TGFβ @adrover.bsky.social @megeblad.bsky.social Nature 2025 www.nature.com/articles/s41...
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Reposted by Jose M. Adrover
Journal of Experimental Medicine @jem.org · 18/08/2025
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/... #TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
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Reposted by Jose M. Adrover
Journal of Experimental Medicine @jem.org · 11/08/2025
#Cancer patients display an elevated burden of #CardiovascularDisease. This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
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Jose M. Adrover @adrover.bsky.social · 12/08/2025
Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social rupress.org/jem/article/...
rupress.org
Heart of the matter: Neutrophils, cancer, and cardiovascular disease | Journal of Experimental Medicine | Rockefeller University Press
Cancer and cardiovascular disease are the leading causes of death worldwide. Cancer patients display an abnormally elevated burden of cardiovascular diseas
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Jose M. Adrover @adrover.bsky.social · 04/08/2025
Thanks to Cancer Discovery for highlighting our manuscript with such a nice summary! Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
aacrjournals.org
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis
Major Finding: A Ly6GhighLy6Clow subset of neutrophils drives pleomorphic necrosis by forming intravascular neutrophil extracellular traps (NET).Concept: Tumor cells adjacent to neutrophil-induced nec...
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Reposted by Jose M. Adrover
Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · 04/08/2025
@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening
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Reposted by Jose M. Adrover
Nature @nature.com · 23/07/2025
Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis go.nature.com/4lzilSb
go.nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Jose M. Adrover
Alejandro Brenes @ajbrenes.com · 27/07/2025
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
biorxiv.org
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
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Reposted by Jose M. Adrover
JHU Bloomberg Distinguished Professorships @jhu-bdps.bsky.social · 23/07/2025
A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.
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Reposted by Jose M. Adrover
Mikala Egeblad @megeblad.bsky.social · 17/07/2025
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis. 🔗 www.nature.com/articles/s41... @jhu-bdps.bsky.social @nature.com
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
This project started when I joined the @megeblad.bsky.social lab at @cshlnews.bsky.social, and continued at @hopkinsmedicine.bsky.social and at @crick.ac.uk, with help from many colleagues along the way! It has been an absolute pleasure to work with Mikala and the rest of the team! (13/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
We show, therefore, that tumour necrosis is not a passive phenomenon, but an active phenomenon that we can target by targeting neutrophils or their NET formation ability. And by reducing tumour necrosis we can reduce metastatic spread. (12/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
There, they form NETs and enter a feedforward loop with platelets that ultimately leads to the blockage of blood flow and subsequent necrosis of downstream tumour regions. This induces cancer cells around these necrotic regions to change and become more metastatic. (11/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
In summary, we found that the tumour changes the haematopoietic compartment and drives the production of vascular-restricted neutrophils. Then, neutrophils leave the bone marrow and enter the bloodstream, eventually reaching the tumour vasculature. (10/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
These neutrophils form NETs more efficiently than normal neutrophils, interact more with platelets, and, intriguingly, cannot extravasate and are stuck in the vasculature. We called them vascular-restricted neutrophils (vrPMNs). (9/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
But why are neutrophils forming NETs in the vasculature? We found that the tumour communicates with the bone marrow and changes myelopoiesis to produce a novel neutrophil subpopulation. (8/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
Using spatial transcriptomics, we found that tumour necrosis increased metastasis because cancer cells in peri-necrotic areas gained pro-metastatic traits in a TGFb-driven manner. (7/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
We found that the process was driven by NETs. When we block NETs genetically or pharmacologically, tumour necrosis is greatly reduced. This, interestingly, also reduced metastatic spread. (6/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
These aggregates were blocking blood flow in the tumour, and that caused the necrosis of downstream tumour regions. (5/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
Interestingly, around necrotic regions we found vessels that contained intraluminal aggregates of neutrophils, NETs and platelets. (4/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
We found that the architecture of necrosis was peculiar and intricate in different tumour models (we call it “pleomorphic necrosis”), and these regions were covered by neutrophils and NETs. (3/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
Tumour necrosis is associated with a bad prognosis across the board of cancer types, including in breast cancer. But it was thought to be a passive phenomenon due to cancer growth outpacing nutrient supply. (2/13)
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Jose M. Adrover @adrover.bsky.social · 27/06/2025
Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here: adroverlab.com/open-positio...
adroverlab.com
Open call for a Postdoctoral Fellow - Cancer Macroenvironment Lab
Open postdoctoral position at the Cancer Macroenvironment Lab led by Dr. Adrover at the Francis Crick Institute in London
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Reposted by Jose M. Adrover
Hannah Garner @hannahgarner.bsky.social · 08/05/2025
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵 www.sciencedirect.com/science/arti...
sciencedirect.com
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread
Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…
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Jose M. Adrover @adrover.bsky.social · 29/04/2025
I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!
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Reposted by Jose M. Adrover
Cancer Research UK @cancerresearchuk.org · 27/04/2025
William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer. #AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk
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Cancer Research UK @cancerresearchuk.org · 26/04/2025
If you’re attending #AACR25 stop by and say "Hi!" to our colleagues in @cancergrand.bsky.social at stand 2327, and Cancer Tools at stand 2424 in the exhibition hall.
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Jose M. Adrover @adrover.bsky.social · 25/04/2025
I’m thrilled to be presenting our work next Monday the 28th at the #AACR25 in beautiful Chicago!
View of Chicago by night
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Reposted by Jose M. Adrover
Open Box Science @openboxscience.bsky.social · 03/04/2025
OBS #Immunology Seminar Neutrophils and regulation of skin physiology 📆 Thu, 10th April, 12 pm EDT/5 pm CET 🎙️ Speaker @alazozcan.bsky.social @yalesph.bsky.social @drusqui.bsky.social @cnic @nature.com 📣 Moderator @eugecc.bsky.social us02web.zoom.us/meeting/regi...
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Jose M. Adrover @adrover.bsky.social · 30/03/2025
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
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NicolasAvilaLab @nicolasavilalab.bsky.social · 23/03/2025
Last contribution to the understanding of #neutrophil biology. Superb work from Tommaso, @alazozcan.bsky.social, and Jackson that I had the pleasure to contribute to and see growing during my time at @drusqui.bsky.social lab.
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Reposted by Jose M. Adrover
Andres Hidalgo @drusqui.bsky.social · 19/03/2025
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link: rdcu.be/eeeA2 www.nature.com/articles/s41...
rdcu.be
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
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Jose M. Adrover @adrover.bsky.social · 18/03/2025
The Postdoctoral Career Development Fellowship for Clinicians call at the Francis Crick Institute is open until the 30th of March, and our lab is participating this year! More info here: adroverlab.com/open-call-po...
adroverlab.com
Open call: Postdoctoral career development fellowship for clinicians - Cancer Macroenvironment Lab
Postdoctoral career development fellowship for clinicians: more information about the Cancer Macroenvironment lab and the current open call at the Crick
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Reposted by Jose M. Adrover
Waggoner Lab @labwaggoner.bsky.social · 17/03/2025
High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration @jimmunol.bsky.social doi.org/10.1093/jimm...
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British Society for Immunology @britsocimm.bsky.social · 11/03/2025
🚨 Last chance to register for BSI Oxford and @immunologyoxford.bsky.social's Oxford Immunology Symposium! #OIS25 📅 Date: 24 March 2025 📍 Location: Oxford Mathematical Institute 🎤 Featuring talks on adaptive & innate immunity and interdisciplinary insights Register NOW: t.co/tlXp9dddqo
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Reposted by Jose M. Adrover
Peggy Goodell @goodell-lab.bsky.social · 06/03/2025
Thrilled to share our new work on #aging in the murine hematopoietic system! There is a lot here- stem cell numbers, self-renewal rates, mutation rates, mutation signatures, clonal fitness, environmental effects...
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British Society for Immunology @britsocimm.bsky.social · 04/03/2025
Get ready for #WorldImmunologyDay2025! 🌎 Join us at The Francis Crick Institute on 24 April to explore "The immune system and your brain" 🧠 Hosted by @claudiahammond.bsky.social and run by @britsocimm.bsky.social, @natureportfolio.nature.com and @crick.ac.uk Register for FREE now: bit.ly/41m8kP9
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