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Patrick MacDonald🇨🇦

@bcellorg.bsky.social
968 followers 1.3K following 102 posts

Professor. CRC. University of Alberta. University of Michigan. Diabetes. Biobanking. Cells, tissues, data. HumanIslets.com, IsletCore.ca, bcell.org

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Reposted by Patrick MacDonald🇨🇦
Alex Usher @alexusherhesa.bsky.social · 16/09/2026
And a blog post.
higheredstrategy.com
The Macdonald-Laurier Institute’s Crap H-Index Paper | HESA
Today I want to focus on a publication which came out from the Macdonald-Laurier Institute called   “The equity excellence trade-off: A study of EDI in the Canada Research Chairs programs” which appea...
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 04/09/2026
The comparative cell physiology of stem-cell-derived and primary human beta cells. A new review from our group and colleagues. rdcu.be/1GZjWQVvfQca
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The Beaverton @thebeaverton.com · 28/08/2026
Canadians wonder if they can win trade war against famously self-sacrificing and unified Americans
thebeaverton.com
Canadians wonder if they can win trade war against famously self-sacrificing and unified Americans
OTTAWA - With tensions continuing to ratchet in the face of President Trump's unilateral trade war, Canadians are openly wondering how they will fare against the notably harmonious, disciplined, and s...
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Mark Carney @mark-carney.bsky.social · 22/08/2026
For over a year, Canada has worked intensively and in good faith with the United States to negotiate a new comprehensive trade deal. We have been pragmatic, patient, and persistent. Our goal has always been to get the best deal for Canadians, never a deal at any price or on any time frame.
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The Globe and Mail @theglobeandmail.com · 22/08/2026
theglobeandmail.com
Canada will retaliate with trade measures on U.S. on Sept. 8, Carney says
‘Unacceptable’ demands from U.S. prompted Canada to walk away from deal, Prime Minister says
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Alexander Bartelt @barteltlab.bsky.social · 21/07/2026
We wrote a thing on how oxidative stress causes hepatic insulin resistance based on an article in @natmetabolism.nature.com link.springer.com/article/10.1...
link.springer.com
How oxidative stress leads to hepatic insulin resistance - Immunity & Inflammation
Abstract Hepatic insulin resistance is a key aspect of obesity-linked metabolic dysfunction, but the molecular mechanisms are still insufficiently understood. Now, a new study shows that reactive oxyg...
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Reposted by Patrick MacDonald🇨🇦
Mark Huising @huisinglab.bsky.social · 21/06/2026
New paper in @diabetologiajnl.bsky.social on paracrine control of insulin secretion, led by the talented newly minted Dr. Ryan Hart (@ryanhart13.bsky.social). 1/5 doi.org/10.1007/s001...
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Karolin Luger @nucleosomepolice.bsky.social · 20/06/2026
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
nytimes.com
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
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Reposted by Patrick MacDonald🇨🇦
Francis Lynn 🇨🇦 @nictitate.bsky.social · 13/06/2026
Excited to see this out! www.science.org/doi/10.1126/sciadv.…
science.org
Regenerative macrophages enhance stem cell–derived β cell function and engraftment
SC-β and SC-MReg coaggregates have improved insulin secretion, metabolic function, and reverse hyperglycemia in diabetic mice.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 09/06/2026
Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation www.biorxiv.org/content/10.6...
biorxiv.org
Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation
Stem-cell-derived β-like-cells (SCβ-cells) provide a promising platform for diabetes modelling and cell replacement therapy, but their incomplete functional maturation remains a challenge. Here, we co...
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 11/05/2026
I’ve been off of social media…. But this is one reason to come back. Good stuff.
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CIRTN-R2FIC @cirtn.bsky.social · 01/05/2026
(🧵 1/22) Many publications from the CIRTN labs this Spring 🌷! Works are from Drs Bruin, MacDonald, Johnson, Mulvihill, Chen, Verchere, Kolic, Huang, Hull-Meichle, Kin, Shapiro, Korbutt, Pepper, P. MacDonald, T. MacDonald, Rideout, Riddell, Rutter, Rabasa-Lhoret and Prentice.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 11/05/2026
From pancreas and islet resources to diabetes insights link.springer.com/article/10.1...
link.springer.com
From pancreas and islet resources to diabetes insights - Diabetologia
Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the de...
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Reposted by Patrick MacDonald🇨🇦
CIRTN-R2FIC @cirtn.bsky.social · 02/02/2026
(🧵1/23) First month of 2026: complete✅! Many papers coming from CIRTN scientists, including works from the labs of Drs Bruin, Lynn, Estall, Ferdaoussi, Fullerton, Hull-Meichle, Pepper, Korbutt, Levings, Lim, Mulvihill, Rabasa-Lhoret, Riddell, Rutter, Tsai, Woo and Verchere! 📝
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Robson Fletcher @robsonfletcher.com · 21/01/2026
After the World Trade Center was attacked (just four miles from Trump Tower), more than 40,000 Canadians in uniform fought alongside their U.S. allies in Afghanistan. More than 2,000 Canadians were wounded. These 158 didn't make it home. And now this guy is giving lectures on gratitude.
Portrait-style photos of the men and women of the Canadian military who were killed during the Afghanistan war of the early 21st century. Photos via afghanistanacanadianstory.ca
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 03/12/2025
Take a look behinds the sciences of our recent work!
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Journal of Clinical Investigation @jci.org · 02/12/2025
Behind the Scenes: Featuring authors Theodore dos Santos, Xiao-Qing Dai, Patrick E. MacDonald, James G. Lyon, Aliya F. Spigelman, Nancy Smith, Tina Dafoe, and Austin Bautista and their work with IsletCore
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Journal of Clinical Investigation @jci.org · 02/12/2025
What can surviving pancreatic cells tell us about type 1 diabetes? Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...
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Waggoner Lab @labwaggoner.bsky.social · 02/12/2025
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes @jci.org @bcellorg.bsky.social @ualberta.bsky.social #T1D www.jci.org/articles/vie... www.jci.org/articles/vie...
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Daniel Drucker @danieljdrucker.bsky.social · 01/12/2025
An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie...
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CIRTN-R2FIC @cirtn.bsky.social · 25/11/2025
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta. youtu.be/UlHn_1Fz3ck?...
youtu.be
#1 Islets in a Pod with Dr. Patrick MacDonald
YouTube video by CIRTN-R2FIC
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Krista Lamb @kristalamb.bsky.social · 25/11/2025
It was a pleasure to attend the @cirtn.bsky.social workshop. I could not be more impressed by the incredible trainee presentations. And it was a special pleasure to present the first CIRTN Science Communication Award to three amazing scientists: Lahari Basu, Maria Galipeau and Cassandra Locatelli!
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 24/11/2025
Unfortunately can’t be there in person this year, but wishing everyone attending @cirtn.bsky.social national meeting a good time in Toronto!
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CIRTN-R2FIC @cirtn.bsky.social · 17/11/2025
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 14/11/2025
'Icicle kick' goes viral: CPL final tops 1 billion views www.theglobeandmail.com/gift/aaa9fe…
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 06/11/2025
“The New York Times found that at critical points, as measles was gaining new footholds in Canada, provincial politicians stopped public health officials from speaking out about the value of getting vaccinated” www.nytimes.com/2025/11/06/w...
nytimes.com
Canada Is About to Lose Its Status as Having Eliminated Measles
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Joey Coleman @joeycoleman.ca · 04/11/2025
Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library. This is wonderful for such a valuable archive to be given to a public municipal library. www.guelphpl.ca/Modules/News...
guelphpl.ca
Robert Munsch donates his archives to Guelph Public Library
Robert Munsch donates his archives to Guelph Public Library
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Alex Usher @alexusherhesa.bsky.social · 04/11/2025
Budget analysis part 1
youtube.com
Canadian Federal Budget 2025 Part 1
YouTube video by Higher Education Strategy Associates
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 04/11/2025
How much are MPs entitled to know about research grants? Not as much as you think. - Globe and Mail
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CIRTN-R2FIC @cirtn.bsky.social · 03/11/2025
🧵(1/4) We have finished up October 2025 🎃, and the CIRTN groups had several more publications coming from the labs of Drs Rennian Wang, Megan Levings and Marc Prentki.
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Chris Wallace @chr1sw.bsky.social · 31/10/2025
This! Fancy web interfaces let you explore the data, but they are not the same as sharing the data. You can do both!
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Jim Woodgett @jwoodgett.bsky.social · 31/10/2025
If you are a Canadian scientist interested in the protection of identifying information about applicants and reviewers of tricouncil grants please read and sign this letter. Thank you. docs.google.com/forms/d/e/1F...
docs.google.com
Open Letter to Protect Tri-Council EDI Data
Why do we need urgent action to protect our data? The mandate of the House of Commons Standing Committee on Science and Research is to review and report on topics relating to science and research in ...
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Support Our Science @supportourscience.bsky.social · 22/10/2025
📢 Support Our Science in the news! We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 17/10/2025
Interesting paper, but does anyone know if the claim that “…The datasets (genome-wide raw sequencing and individual-level clinical data) … are not publicly available due to EU and national legislation” is reasonable? www.nature.com/articles/s41598-025-…
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CIRTN-R2FIC @cirtn.bsky.social · 16/10/2025
🧵(1/4) For the first half of October 2025 we have 3 publications from the CIRTN labs🍁. These papers are from the groups of Drs. Bruce Verchere, Yi-Chun Chen, Francis Lynn, James Shapiro, Tatsuya Kin and Guy Rutter!
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 04/10/2025
bsky.app
@lukaszukab.bsky.social on Bluesky
#ForeverCanadian crew is set up by the pumpkin weighing station (near the museum) at the Smokey Lake pumpkin festival. 🎃 Come on over and sign the petition, please! 🇨🇦
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Hon. Thomas A. Lukaszuk @lukaszukab.bsky.social · 03/10/2025
Today, #ForeverCanadian brought 230,000 petition signatures to Edmonton. Our volunteers will continue collecting signatures until October 28. We need your signature to reach our 300,000 requirement to keep Alberta in Canada. #ableg #Yeg #Yyc #CdnPoli
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CIRTN-R2FIC @cirtn.bsky.social · 01/10/2025
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
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Daniel Drucker @danieljdrucker.bsky.social · 30/09/2025
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 30/09/2025
Yesterday we celebrated our 600th human research islet isolation in support of diabetes research (and then last night isolated the islets in the pic). I’m very fortunate to work with such a dedicated team! See more at www.isletcore.ca
CakeCelebrating 600Islets for research
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Olov Andersson @o-andersson-lab.bsky.social · 24/09/2025
Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum
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Hon. Thomas A. Lukaszuk @lukaszukab.bsky.social · 29/09/2025
My column in the Globe & Mail: “Those challenges notwithstanding, separation is clearly not the answer. Even the talk of separation damages Alberta’s reputation, creates uncertainty, drives away talent and investment, and divides communities.” #cdnpoli www.theglobeandmail.com/opinion/arti...
theglobeandmail.com
Opinion: Yes, Canadians - Albertans do want to stay in Canada
Don’t believe the separatist rhetoric of a few vocal and misguided pundits
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 27/09/2025
Decision to cancel my season tix….justified again.
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CAUT/ACPPU @caut.bsky.social · 25/09/2025
Research is the key to unlocking Canada’s future and it needs proper funding. The federal government must uphold its Budget 2024 commitment to Canadian researchers. Read the Coalition for Canadian Research’s open letter: www.caut.ca/news/coaliti...
caut.ca
Coalition for Canadian Research calls on federal government to fulfil the Budget 2024 research commitments
The Right Honourable Mark Carney, P.C., M.P.Prime Minister of CanadaOffice of the Prime Minister80 Wellington StreetOttawa, ON K1A 0A2
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Daniel Drucker @danieljdrucker.bsky.social · 24/09/2025
Join us this Friday am, in person or online, for new insights into #Islet biology-what should we strive for in islet cell replacement therapy?-some thoughts from Professor Powers, a leader in the field in characterizing human islets across the lifespan #diabetes
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CIRTN-R2FIC @cirtn.bsky.social · 12/09/2025
Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 09/08/2025
From the Ampofo group! www.science.org/doi/10.1126/...
science.org
Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets
The binding of heparan sulfate to IL-1α potentiates the inhibitory action of IL-1α on insulin release.
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 07/08/2025
Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks Maja Duh Marko Šterk, Lidija Križančić Bombek, Patrick E MacDonald, Andraž Stožer, Marko Gosak pubmed.ncbi.nlm.nih.gov/40765144/
pubmed.ncbi.nlm.nih.gov
Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks - PubMed
Coordinated responses of pancreatic beta cell networks to changes in extracellular nutrient concentrations are a well-established phenomenon with significant implications for insulin secretion. This s...
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Reposted by Patrick MacDonald🇨🇦
Lucie🐈‍⬛Catnip @luciecatnip.bsky.social · 01/08/2025
This is now a long-distance relationship, Tim. #cdnpoli
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Patrick MacDonald🇨🇦 @bcellorg.bsky.social · 25/07/2025
The official post: apps.ualberta.ca/careers/post...
apps.ualberta.ca
Postdoctoral Fellow in Islet Biology - Careers@UAlberta.ca
University of Alberta: Careers@UAlberta.ca
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