An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

BETHESDA, MD—The National Institutes of Health announced Tuesday that it would replace its 50-year-old numerical scoring system with a streamlined three-emoji format, in which grant applications will ...

UF-developed biorepository, artificial intelligence tools lead to continued innovations and therapies

A beta cell–targeting, affinity-enhanced TCR fused to a PD-1 agonist inhibits cellular immunity relevant to human type 1 diabetes.

Through an epigenome-wide blood analysis in children of mothers with or without type 1 diabetes, the authors identify epigenetic modifications of type 1 diabetes susceptibility loci through which mate...

Gamma-aminobutyric acid (GABA) is produced in pancreatic beta cells and is implicated in modulating islet function, yet its precise physiological role…

This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Aims/hypothesis Progression to type 1 diabetes is associated with genetic factors, the presence of autoantibodies and a decline in beta cell insulin secretion in response to glucose. Very little is kn...

While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...

The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced du...

3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.

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Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

During type 1 diabetes (T1D) progression, beta cells become dysfunctional and exhibit reduced first-phase insulin release. While this period of beta cell dysfunction is well established, its cause and...