Colorectal cancer is the second deadliest cancer worldwide, and rates are rising alarmingly among younger adults. Although immunotherapy has transformed treatment for some cancers, more than 90% of co...

Immune checkpoint receptors, such as TIGIT, act to restrain T cell responses, but their regulatory mechanisms are poorly understood. Zammit et al. discover that inhibitory TIGIT signaling requires bot...

Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.

This new type of immunotherapy shows promise for treating different cancers including prostate cancer, leukaemia and lung cancer.

A nature-inspired ion trap enabling massively parallel mass spectrometry.

This new type of immunotherapy shows promise for treating different cancers including prostate cancer, leukaemia and lung cancer.

An open-access resource, nano-org, enables researchers to explore and compare the nanoscale 2 organisation of proteins imaged using single-molecule localisation microscopy, advancing insights 3 into cell biology, disease, and drug response.

Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Nature Chemical Biology - This Perspective discusses click biology as an analogy to click chemistry and examines reactions carried out using building blocks present in every living cell, enabling...

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Elucidating the interaction between membrane proteins and antibodies requires whole-cell imaging at high spatiotemporal resolution. Lattice light-sheet (LLS) microscopy offers fast volumetric imaging ...