npj Breast Cancer - Dynamic single-cell systemic immune responses in immunotherapy-treated early-stage HR+ breast cancer patients

Hematopoietic stem cells (HSCs) differentiate into multiple lineages, with such capacity impacted by aging. Here the authors identify Kitlo HSCs as a functionally distinct population that exhibits dis...

Therapeutic T cells engineered to recognize tumour antigens are frequently short-lived and acquire unfavourable phenotypes in tumours. Here authors show that a tandem approach using autologous T cells...

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify dep...

Karen Knudsen is leading Sean Parker's cancer immunotherapy incubator where philanthropy and venture capital meet.

The annual ASCO meeting sets the agenda for the year’s conversations around cancer treatment. We’ll review new data readouts, scrutinize pipelines, and take stock of the pathways ahead for oncology re...

Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...

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Background Immune checkpoint inhibitors (ICIs) have led to enduring responses in subsets of patients with cancer. However, these responses carry the risk of immune-related adverse events (irAEs), whic...

Patients with some gastrointestinal tumors were able to be treated with immunotherapy drugs alone and avoid surgery, chemotherapy or radiation, the study found.

Scientific Reports - LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma

Abstract. The optimal means to prime for effective anti-tumor immunity in a cancer patient remains elusive in the current era of checkpoint blockade. Crafting a strategy to amplify CD8+ T cells while ...

With a new key hire, the Napster cofounder’s cancer fighting non-profit is ready to back the science both governments and markets leave behind.

Understand every aspect of the global economy – and know how to make your next move.

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

This review provides a comprehensive overview of the historical evolution of CAR-T cell therapy, highlighting key advancements that have shaped its success. It details currently approved CAR-T cell tr...