Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...

Inositol-requiring enzyme 1 (IRE1) is one of three known sensor proteins that respond to homeostatic perturbations in the metazoan endoplasmic reticulum. The three sensors collectively initiate an int...

A University of Manitoba-led study successfully eliminated breast-cancer derived brain tumours in mice, using a drug to penetrate the brain and eliminate metastatic brain tumours. After testing 8,500

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The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…

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ALT: a cartoon of a fairy holding a wand and sprinkle fairy dust on them .

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