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Interactions between the prefrontal cortex (PFC) and hippocampus (HPC) are crucial for flexible and memory guided behaviour. Because there are no direct projections from PFC to HPC, it is widely presu...

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

A specific pathway reassigns emotional valence to a known mouse, while the hippocampus’s own representation of that animal’s identity remains stable.

Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypo...

Some studies containing instructions in white text or small font — visible only to machines — will be withdrawn from preprint servers.

Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…

Place cells map terrain geometry, not behavior, revealing a surface-based brain code for real-world navigation.

The arrangement of locus coeruleus neurons in mice points to how the structure mediates specific effects across the brain, a new study shows.

Nature Neuroscience - Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories...

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Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...

In 1946, Tolman et al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...

University of California, Davis Dean, College of Biological Sciences The University of California, Davis (UC Davis) seeks a dynamic, effective, and