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Karen Mohlke

@klmohlke.bsky.social
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Reposted by Karen Mohlke
The American Journal of Human Genetics @ajhgnews.bsky.social · 02/12/2025
📣New today! 📄Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits 🧑‍🤝‍🧑 @alkhawaja.bsky.social @klmohlke.bsky.social & co
cell.com
Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits
This study used single-nucleus approaches to map genetic variants associated with chromatin accessibility and gene expression across liver cell types. Linking these genetic variants to cardiometabolic...
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Reposted by Karen Mohlke
The American Journal of Human Genetics @ajhgnews.bsky.social · 23/09/2025
📣New from @klmohlke.bsky.social & co! 📄Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits www.cell.com/ajhg/fulltex...
cell.com
Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
To investigate the underlying mechanisms of complex traits, we performed an eQTL meta-analysis in skeletal muscle and identified 18,818 conditionally distinct signals for 12,283 genes. Colocalization ...
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Reposted by Karen Mohlke
Sarah Brotman @sarahbrotman.bsky.social · 07/01/2025
I’m excited to share that this manuscript is now published in Nature Genetics! 🧪🧬 🖥️ www.nature.com/articles/s41... The AdipoExpress data can be accessed here: zenodo.org/records/1384... An interactive browser of the colocalization results can be accessed here: adipose.colocus.app
nature.com
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits - Nature Genetics
This study introduces AdipoExpress, an eQTL meta-analysis of 2,344 subcutaneous adipose tissue samples, which triples the size of previous studies and expands the discovery of eQTLs colocalized with G...
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Reposted by Karen Mohlke
Sarah Brotman @sarahbrotman.bsky.social · 28/10/2023
I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the largest adipose eQTL dataset to date (AdipoExpress). @kerrinsmall.bsky.social @klmohlke.bsky.social Laura Scott, and others 🧪🧬 🖥️ #GeneSky 1/8 www.biorxiv.org/content/10.1...
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