Polygenic indexes (PGIs) trained on samples of European genetic ancestries often lose substantial predictive power when applied to non-European ancestries. While this portability problem is well recog...

Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...

Newcastle University

A consequence of Mendel's First Law is that siblings' genetic relatedness varies randomly (with a mean of 50% and a standard deviation of ~4%). We use molecular

GeneticScores.org provides tools and data to help AI developers and human health researchers make better polygenic scores

The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...

The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...

Tumour mutational burden (TMB), reflecting the number of mutations present in the DNA of a tumour, is a biologically appealing biomarker of a response to immune-checkpoint inhibitors (ICIs). Nonethele...

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In 394,005 UK individuals with exome sequencing data, Wu et al. find 56 neuroticism-associated genes (18 novel) and quantify the heritability explained by rare coding variants, highlighting the associ...

In his research on the brain, Daniel Gustavson looks for clues about when cognitive decline beginsAccording to Daniel Gustavson, assistant research professor in

PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com

<p>The Symposium will showcase transformative, fundamental research in Human Genetics for a broad audience of biologists and biomedical researchers. To this end, we bring together an interdisciplinary...

Comparison of association signals in UK Biobank using different strategies for assessing genetic variation shows that whole-exome sequencing combined with array genotyping and imputation offers simila...

Ancient DNA has been recovered from Bronze Age cheese residue, revealing cultural communication, the spread of fermenting techniques, and the domestication of microorganisms by the Xinjiang Xiaohe pop...

An Owner's Guide to the Human Genome

The Department of Statistics in the Faculty of Science at the University of British Columbia (UBC), Vancouver invites applications from outstanding new investigators for two tenure-track positions at ...