Across the 3 billion ‘letters’ of our DNA, we each carry around 6 million variations. Researchers are unravelling their effects on our lives.

The Crick's clinical PhD programme.

The Crick's clinical PhD programme.

Genetic variants in RNU4-2, which encodes U4, a key non-coding small nuclear RNA (snRNA) component of the major spliceosome, were recently shown to cause a prevalent neurodevelopmental disorder (NDD) ...

Germline pathogenic BRCA1 variants predispose women to breast and ovarian cancer. Despite accumulation of functional evidence for variants in BRCA1 , over half of reported single-nucleotide variants (...

Nature Reviews Genetics - In this Tools of the Trade article, Christina Kajba and Michael Herger describe their screening platform, based on pooled prime editing, for large-scale functional...

Herger and Kajba et al. introduce a prime editing platform to screen genetic variants for functional effects in haploid human cells. Negative and positive selection screens identify loss-of-function v...

Prime editing screens allow precise and scalable studies of genetic variants in their native genomic context but are limited by variable editing effic…

Recently, de novo variants in an 18 nucleotide region in the centre of RNU4-2 were shown to cause ReNU syndrome, a syndromic neurodevelopmental disorder (NDD) that is predicted to affect tens of thous...

With the surge in the number of variants of uncertain significance (VUS) reported in ClinVar in recent years, there is an imperative to resolve VUS at scale. Multiplexed assays of variant effect (MAVE...

Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

Herger and Kajba et al. introduce a prime editing platform to screen genetic variants for functional effects in haploid human cells. Negative and positive selection screens identify loss-of-function v...

Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...

Salary for this Role: Between £39,950 and £45,825 dependent on skills and experience Job Title: Senior Laboratory Research Scientist - Findlay Lab Reports to: Greg Findlay Closing Date: 23/Mar/2025 23...

Open to candidates of Black or mixed Black heritage only.

2025 PhD recruitment is now open!

Open to candidates of Black or mixed Black heritage only.