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Andrea Ganna

@andganna.bsky.social
1.7K followers 690 following 217 posts

Associate Prof in health data science @HiLIFE_helsinki @FIMM_UH - MGH/Harvard - Playing with all kind of data - dsgelab.org

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Reposted by Andrea Ganna
Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 03/07/2026
Job opportunity! 📢 The Faculty of Science and FIMM @helsinki.fi are recruiting a Research Fellow / University Researcher in AI for Population Health and Genomics for a fixed-term appointment of maximum 4 years. Apply by July 31: jobs.helsinki.fi/job/Helsinki... @andganna.bsky.social
Promotional graphic for a Research Fellow (University Researcher) position in AI for population health and genomics at the Institute for Molecular Medicine Finland (FIMM), HiLIFE Unit, University of Helsinki. The left side features the FIMM and University of Helsinki logos alongside a large blue, chromosome-like 3D illustration. On the right, bold black text announces the position title, followed by the subtitle "In AI for Population Health and Genomics." At the bottom, bold text states: "Apply by 31 July."
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Andrea Ganna @andganna.bsky.social · 17/07/2026
Can we quantify the impact of individual DNA mutations on healthcare costs? In our new preprint we ran the largest GWAS of healthcare costs to date: 1,429,889 individuals, 11 cohorts, 7 countries, across inpatient, outpatient, primary care, and prescription expenditure 💰🧬
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Human Technopole @humantechnopole.bsky.social · 13/07/2026
🔎 “Nowadays we have more data than ever.” 🧬 How can #healthdata, #genomics and #AI help us better understand disease? Our @andganna.bsky.social explains how large-scale datasets can reveal risk factors, disease pathways and patterns that targeted research may miss. youtu.be/kTXxmYiCZJU
youtu.be
#MeetTheSpeaker - Health Data and a Fairer AI with Andrea Ganna
YouTube video by Human Technopole
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Andrea Ganna @andganna.bsky.social · 05/06/2026
📢I'm setting up a new team at the @humantechnopole in Milan. We have several openings in AI applied to nationwide health data, biobank-scale -omics. Milan is a beautiful city and at @humantechnopole is top notch. You can find post-doc positions here: careers.humantechnopole.it/job/Postdoc/...
careers.humantechnopole.it
Postdoc
Postdoc
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Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 02/06/2026
FIMM is joining forces with @ellisinstitute.fi to launch the FINe-Health Foundry project aiming to build the world’s first nationwide healthcare foundation model. The project has received ~€5M in Business Finland's Rise to Challenge funding. @andganna.bsky.social www.helsinki.fi/en/hilife-he...
helsinki.fi
Rise to Challenge funding for building the world’s first nationwide foundation model for healthcare | HiLIFE – Helsinki Institute of Life Science | University of Helsinki
FIMM joins forces with ELLIS Institute Finland to establish a new, globally competitive excellence cluster aimed at unlocking next-generation decision-making in healthcare and beyond.
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Reposted by Andrea Ganna
Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 15/05/2026
MSc Lisa Eick from @andganna.bsky.social's group will defend her doctoral dissertation "Improving Cross-Biobank Genetics Through Phenotype Refinement and Machine Learning" @helsinki.fi on 29 May at 13:00. Opponent: Associate Prof Sandra Sanchez-Roige (UCSD) 🔗 tapahtumat.helsinki.fi/en-FI/page/6...
Promotional graphic for a doctoral dissertation defense featuring a portrait of a young woman with red hair on the right side inside a circular frame. On the left, large white text reads “LISA EICK” with the dissertation title below: “Improving Cross-Biobank Genetics Through Phenotype Refinement and Machine Learning.” The event details list “29 May 2026 at 13.00” and “Biomedicum 1, Lecture Hall 3.” A dark banner at the bottom names the opponent as Sandra Sanchez-Roige from the University of California San Diego. The top-left corner includes a diagonal ribbon labeled “Doctoral Dissertation” with a trophy icon. Logos for the University of Helsinki and Institute for Molecular Medicine Finland appear at the bottom.
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Andrea Ganna @andganna.bsky.social · 06/05/2026
New preprint on a controversial topic: Through which socioeconomic mechanisms do individuals with higher genetic predisposition for educational attainment end up with higher income over their working life? We study this using uniquely rich Finnish data.
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Andrea Ganna @andganna.bsky.social · 29/12/2025
New preprint 👇 Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery? We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery. Led by Lisa Eick & Zhiyu Yang!
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Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 20/03/2026
This week on The Genetics Podcast, @andganna.bsky.social joined host Patrick Short to discuss advances in genetics and data-driven medicine, including the the promise and limits of polygenic risk scores for disease prediction and clinical trials. 🎧 podcasts.apple.com/fi/podcast/e...
Promotional graphic for “The Genetics Podcast” featuring a portrait of a man wearing round glasses and a striped sweater against an orange background with faint DNA letters. Large white text reads: “From polygenic scores to AI-driven medicine.” Smaller text below: “With Andrea Ganna of the Institute for Molecular Medicine Finland.” Episode number shown as “Ep 231.”
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Andrea Corbetta @corbettandrea.bsky.social · 29/01/2026
🚨New preprint out Mapping real-world statin adherence at population scale (doi.org/10.64898/202...) We analysed >1 million long-term statin users in Finland and Italy (Lombardy), identified adherence patterns, and examined baseline factors associated with declining adherence.
doi.org
Longitudinal patterns and determinants of statin adherence in over one million individuals from Finland and Italy
Medication adherence is critical for effective management of chronic diseases and reducing healthcare burdens. Statins, commonly prescribed for cardiovascular disease prevention, require sustained, li...
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Andrea Ganna @andganna.bsky.social · 29/12/2025
New preprint 👇 Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery? We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery. Led by Lisa Eick & Zhiyu Yang!
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Andrea Ganna @andganna.bsky.social · 15/12/2025
🌟 Applications for the 2026 Leena Peltonen School of Human Genetics are open! Back after a great 2025 edition: ~20 global leaders and ~20 PhD students shaping the future of genomics. 📅 July 26–30, 2026 📍 Wellcome Genome Campus, UK 📝 Apply by March 6 → www.lpshg.com
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Andrea Ganna @andganna.bsky.social · 15/12/2025
🌟 Applications for the 2026 Leena Peltonen School of Human Genetics are open! Back after a great 2025 edition: ~20 global leaders and ~20 PhD students shaping the future of genomics. 📅 July 26–30, 2026 📍 Wellcome Genome Campus, UK 📝 Apply by March 6 → www.lpshg.com
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Reposted by Andrea Ganna
Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 11/11/2025
— Genetiikka vaikuttaa persoonallisuuteemme, ja persoonallisuutemme vaikuttaa siihen, mitä opiskelemme. Voimme nyt havaita näitä yhteyksiä selvemmin suoraan DNA:stamme, sanoo @andganna.bsky.social. Linkki Nature Genetics -lehdessä julkaistuun tutkimukseen: www.nature.com/articles/s41...
nature.com
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
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Reposted by Andrea Ganna
Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 03/12/2025
Jakob German from @andganna.bsky.social's group @hilife-helsinki.bsky.social will defend his doctoral dissertation "Genetically-Informed Real-World Evidence and Trial Design on 12 Dec. Linda Kachuri, Stanford University, will serve as the opponent. Welcome! 🔗 tapahtumat.helsinki.fi/en-FI/page/6...
Announcement graphic for Jakob German's Doctoral Dissertation titled ‘Genetically-Informed Real-World Evidence and Trial Design.’ The graphic includes event details (12 December 2025 at 13:15, Oral and Dental Centre hall H3.034) and lists the opponent Linda Kachuri from Stanford University. On the right side, there is a portrait of Jakob German in a light-colored shirt.
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Rosa Cheesman @rosacheesman.bsky.social · 04/11/2025
1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...
nature.com
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
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Andrea Ganna @andganna.bsky.social · 04/11/2025
Happy to have contributed to this study! Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers
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Andrea Ganna @andganna.bsky.social · 03/11/2025
EU vice-president Virkkunen launches RAISE: resource for AI science in Europe. Not exactly clear what this entails. But i understand: more money, more networking.
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Andrea Ganna @andganna.bsky.social · 03/11/2025
Yoshua Bengio and the role of EU in AI development
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Reposted by Andrea Ganna
Daniela Fusco @danifusco.bsky.social · 17/10/2025
Are you in #Boston for #ASHG25? Come by and check out my poster (#1023) today from 2:30–4:30 PM. Would love to connect and discuss about it :)
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Andrea Ganna @andganna.bsky.social · 16/10/2025
🎉 New preprint out! "Removing genetic effects on plasma proteins enhances their utility as disease biomarkers" We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease 👉 doi.org/10.1101/2025...
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Patrick Phillips @patrickphillips.bsky.social · 06/10/2025
Very important paper for the geroscience hypothesis. Healthy aging is critical, even in the face of obvious disease states.
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Andrea Ganna @andganna.bsky.social · 08/10/2025
💥 New preprint & our first RCT! 💥 Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention? GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults
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Karsten Suhre @ksuhre.bsky.social · 01/10/2025
A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...
nature.com
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry
Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.
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Andrea Ganna @andganna.bsky.social · 30/09/2025
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new study in Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting progression • Lifespan PRS predicts survival better
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Andrea Ganna @andganna.bsky.social · 23/09/2025
“Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model” in collaboration with Pekka Marttinen at @AaltoUniversity www.sciencedirect.com/science/arti...
sciencedirect.com
Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model
Health registers provide valuable insights into individuals’ health trajectories. This study explores the use of deep learning to model and analyze th…
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Andrea Ganna @andganna.bsky.social · 23/09/2025
If you are interested in our pilot use of cross-EU health data ahead of the European Health Data Space implementation, check this out pubmed.ncbi.nlm.nih.gov/40926479/
pubmed.ncbi.nlm.nih.gov
User journeys in cross-European secondary use of health data: insights ahead of the European Health Data Space - PubMed
The European Health Data Space (EHDS) regulation aims to facilitate cross-border sharing of health data across Europe. However, practical challenges related to data access, interoperability, quality, ...
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Reposted by Andrea Ganna
Konrad @konradjk.bsky.social · 18/09/2025
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
nature.com
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics
Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...
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Andrea Ganna @andganna.bsky.social · 17/09/2025
Cool work from @ewanbirney.bsky.social Moritz Gerstung, Tom Fitzgerald about modeling health trajectories with generative AI! www.nature.com/articles/s41...
nature.com
Learning the natural history of human disease with generative transformers - Nature
Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never...
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Abdel Abdellaoui @dr-appie.bsky.social · 08/09/2025
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences. My love letter to social science genetics: communities.springernature.com/posts/a-love...
communities.springernature.com
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
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Andrea Ganna @andganna.bsky.social · 27/08/2025
Check out @tuomohartonen.bsky.social blog post on our study, out today in Nature Genetics, comparing electronic health record-based risk scores with genetic polygenic scores, and how they work better together! tuomohartonen.substack.com/p/medical-re...
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Tuomo Hartonen @tuomohartonen.bsky.social · 27/08/2025
Are electronic health records (EHR) more predictive of disease onset than polygenic scores? Can we transfer EHR-based prediction models between countries? Our study on these questions using 3 biobank-based studies with N>845K, is out in @natgenet.nature.com today: www.nature.com/articles/s41...
nature.com
Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores - Nature Genetics
Comparison of electronic health record-based phenotype risk scores (PheRS) and polygenic scores (PGS) across 13 common diseases and three biobank-based studies indicates that PheRS and PGS may provide...
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Andrea Ganna @andganna.bsky.social · 22/08/2025
Happy to see this online! Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.
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Andrea Ganna @andganna.bsky.social · 22/08/2025
Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion medical events. Including: diagnoses, medications, lab values, procedure Cons: model is not shared (and unlikely will be) arxiv.org/pdf/2508.12104
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Andrea Ganna @andganna.bsky.social · 07/08/2025
Papers of the months in Health Data Science healthdatascience.substack.com/p/monthly-up...
healthdatascience.substack.com
Monthly update - July 2025
Picks of the Month
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Andrea Ganna @andganna.bsky.social · 05/08/2025
The iPSYCH study represents a unique example to understand the ethical and legal challenges of using existing samples/data for health research. A thread 🧵 www.science.org/content/arti...
science.org
Blood taken from Danish babies ended up in huge genetic study—without consent
The iPsych project, which investigates the genetics of psychiatric disorders, has sent 140,000 opt-out notices amid backlash
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Manu Saraswat @manusaraswat.bsky.social · 01/08/2025
Dived into past, present & future of human genetics with brilliant students & mentors.Grateful for the chance to present my work on personalized sequence→expression prediction and discussions with @sashagusevposts.bsky.social @bpasaniuc.bsky.social @mashaals.bsky.social @tuuliel.bsky.social & others
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Eva Holtkamp @evaholtkamp.bsky.social · 31/07/2025
This was such a special event! So grateful that I could be part of it, learning about great science, making truly unique connections with amazing fellow students and tutors, and even learning how to punt 🛶 Huge thanks to everyone who helped bring this unique school back to life!
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Alejandra Medina-Rivera @alemedinarivera.bsky.social · 01/08/2025
It was a pleasure to be part of this summer school. Students were amazing, it was a great experience getting the chance to discuss one on one without hierarchy for three days with them. They taught me so much.
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Pia Rautenstrauch @prauten.bsky.social · 01/08/2025
Truly grateful for the exceptional opportunity to participate in #LPSHG2025 last week, featuring a stellar ✨ lineup of leading researchers who doubled as tutors, alongside inspiring fellow PhD students. Excited to apply my learnings and see where this collaborative spirit takes genomics next!
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Rasha Shraim @rashabun.bsky.social · 01/08/2025
Great meeting! Renewed excitement about all the cool research happening in genetics right now 🧬
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Giacomo Bignardi @giacomobignardi.bsky.social · 31/07/2025
The pace and breadth of discovery are mind-blowing and made even better by the cool people involved. So grateful to have taken part in this event 🙏 Now to process it and try to apply a tiny fraction to new research projects
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Andrea Ganna @andganna.bsky.social · 30/07/2025
Leena Peltonen School of Human Genetics in full-swing! @gosiatrynka.bsky.social @dgmacarthur.bsky.social @bpasaniuc.bsky.social @tuuliel.bsky.social @hilarycmartin.bsky.social @sashagusevposts.bsky.social @zkutalik.bsky.social @mashaals.bsky.social @alemedinarivera.bsky.social
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Andrea Ganna @andganna.bsky.social · 30/06/2025
🇪🇺 The European Commission R&D website has highlighted our ERC-funded work on AI for health data. This is a part of a larger effort to highlight how EU-funded AI research has enabled innovation and discoveries in life sciences. cordis.europa.eu/article/id/4...
cordis.europa.eu
AI-driven approaches to personalised healthcare
Applying artificial intelligence to datasets covering health as well as other risk factors could be key to developing more predictive and...
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Andrea Ganna @andganna.bsky.social · 18/06/2025
Can we use genetics to make real-world evidence more like randomized trials and improve trial design in the process? In our latest paper, we emulate 4 cardiometabolic RCTs in FinnGen and test how polygenic scores can improve trial emulation rdcu.be/eryti
rdcu.be
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Nature Genetics - This study integrates polygenic risk scores with four emulated clinical trials using FinnGen data and shows the feasibility of this approach while highlighting potential pitfalls.
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Andrea Ganna @andganna.bsky.social · 17/06/2025
Ely Lilly buys Verve therapeutics www.investors.com/news/technol...
investors.com
Eli Lilly Gets Into The Gene-Editing Space With $1 Billion Takeout
The companies were already collaborating on a handful of cardiovascular-focused gene-editing treatments.
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René Mõttus @renemottus.bsky.social · 09/06/2025
New preprint: One of the largest studies (N = 67,000) on how sexual desire varies with age, sexual orientation, education, job, number of children, recent birth, and relationship satisfaction, and how the trends differ by gender. doi.org/10.21203/rs....
doi.org
Associations Between Demographic and Relationship Variables and Sexual Desire: Findings from a Large-Scale Estonian Biobank Dataset
Sexual desire plays a crucial role in human well-being and relational dynamics, yet its demographic and relational predictors remain insufficiently understood. Leveraging a uniquely large and represen...
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Institute for Molecular Medicine Finland (FIMM) @fimm-uh.bsky.social · 02/06/2025
The FIMM Young Investigator for April 2025 is Feiyi Yang, a doctoral researcher supervised by @andganna.bsky.social & Tiinamaija Tuomi. Warm congratulations to her for her recent 1st-author publication on the effects of parental autoimmune diseases on type 1 diabetes in offspring in Cell Genomics!
A photo of Feiyi Wang, Doctoral Researcher, named FIMM Young Investigator of the Month, with logos of FIMM, HiLIFE, and University of Helsinki.
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Michel Nivard @michelnivard.bsky.social · 01/06/2025
If you are seriously considering an academic career in Europe, and you are weather hardened by the mid-west or north east, this is an amazing opportunity!
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