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Volker Boehm

@volkerboehm.bsky.social
193 followers 339 following 11 posts

RNA-centric Staff Scientist | Nonsense-mediated decay | Exon junction complex | RBPs | Gehring Lab @ University of Cologne 🧫 orcid.org/0000-0001-7588-9842

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Reposted by Volker Boehm
Uwe Ohler @uweohler.bsky.social · 30/09/2026
Our #genome still holds many mysteries… Want to help figuring out what is actually translated into proteins and how it is regulated? Our research network #ORFeus is looking for motivated #PhD students to join projects across Europe. Deadline is soon (Oct 22), have a look! www.orfeus-dn.eu/apply/
orfeus-dn.eu
Apply to ORFeus — 15 fully funded PhD positions
15 fully funded PhD positions across Europe, starting 2027. Applications open 1 October and close 22 October 2026. Rank up to three projects.
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Reposted by Volker Boehm
SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 30/03/2026
Review by the Mühlemann Lab with first author Wojciech Teodorowicz "Molecular determinants and therapeutic targeting of stop codon readthrough in eukaryotic translation" @jmolbiol.bsky.social nccr-rna-and-disease.ch/news/article... @omuhlemann-lab.bsky.social @unibe.ch
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MPI for Biology of Ageing @mpiage.bsky.social · 02/09/2026
🌱 Two of our labs have achieved the highest My Green Lab Certificate rating! We are excited to share that the Schaefer/Frentz department and the Huppertz lab have received the Green rating - the highest level possible! 👏 www.age.mpg.de/456869/Green... @inahuppertz.bsky.social
age.mpg.de
Top Marks for Sustainable Research
Two biology labs achieved the highest Green Lab certification, showcasing excellence in sustainable research practices.
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Reposted by Volker Boehm
Michael Feldbrügge @mfeldbruegge.bsky.social · 02/09/2026
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA: 🔬 DC1: Live-cell imaging of RNA transfer and function 📦 DC10: Mechanisms and applications of RNA delivery RNA biology, fungi, extracellular vesicles and advanced imaging. www.mikrobiologie.hhu.de/en/
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Markus Landthaler @landthalerm.bsky.social · 26/08/2026
www.nature.com/articles/s41... @mdc-bimsb.bsky.social
nature.com
Ultrafast and reference-free sequence discovery in single-cell data - Nature
Malva enables ultrafast, reference-free searching of raw single-cell sequences across millions of cells, transforming static transcriptomic atlases into dynamic resources for understanding the functio...
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Reposted by Volker Boehm
Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Torben Heick Jensen @heick.bsky.social · 18/08/2026
Vacant postdoc position in RNA biology available in our lab - Århus, Denmark. Please inquire with any questions or simply apply using this link: international.au.dk/about/profil...
international.au.dk
Postdoc position in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at RNA Biology and Innovation, Aarhus University
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Hennig-Lab @hennig-lab.bsky.social · 08/08/2026
New bioRxiv preprint from our lab: www.biorxiv.org/content/10.6...: RNA recognition by tandem RRM RBPs is governed by a finely balanced conformational equilibrium. Both weakening and strengthening transient interdomain coupling reduce RNA binding. #NMR #RNABiology #StructuralBiology #bioRxiv
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Reposted by Volker Boehm
Max Perutz Labs Vienna @maxperutzlabs.ac.at · 03/08/2026
👀 Keep cutting-edge RNA research running behind the scenes! The @sebastianfalk.bsky.social lab is looking for a Research Technician/Lab Manager to support research on the molecular machines that process RNA using structural biology, biochemistry, and biophysics ➡️ tinyurl.com/nrjj6bvt
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Kathrin Fröhlich @microberna.bsky.social · 09/07/2026
The Bacterial RNA Biology Group in Jena is hiring a new PhD student! 🔬🧫🧬 We are looking for a motivated candidate to study bacteriophages of the opportunistic pathogen Klebsiella pneumoniae. 🔥 Apply by July 26, 2026 🔥 Details on the position and application: jobs.uni-jena.de/jobposting/9...
jobs.uni-jena.de
Doctoral Researcher in Molecular Microbiology (m/f/d)
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CRC1678 @crc1678.bsky.social · 09/07/2026
🚴 City Cycling 2026 – Thank you for riding with us! Great effort from the #CRC1678 team this year! Together with the University Hospital Cologne team, we reached 2nd place across the city. Thanks to everyone who joined the ride and supported a healthier, more sustainable future 🌿💙
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Reposted by Volker Boehm
Schlundt lab @lab-nmr.bsky.social · 07/07/2026
Interested in RNA and proteins? Perfect! 😀 We seek to fill a fully funded 3+ years PhD position for a project on pre-mRNA splicing regulation using structural biochemistry in combination with cell biology and bioinformatics. Find more information on our lab's homepage and get in contact via e-mail!
biochemie.uni-greifswald.de
Analytische Biochemie - Fakultät - Universität Greifswald
Universität Greifswald
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EMBL @embl.org · 06/07/2026
Congratulations, Matthias Hentze! The EMBL Director has been awarded the German Order of Merit for his outstanding achievements in life science research and in building scientific structures across Germany and beyond. www.embl.org/news/awards-...
Matthias Hentze after receiving the Bundesverdienstkreuz at a ceremony on 2 July 2026. Also pictured are his wife Sabine Hentze, BIAC member and EMBL alumna, and Eckart Würzner, Lord Mayor of Heidelberg, who presented the award. ©Philipp Rothe
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Rhineland RNA Club @rhinelandrna.bsky.social · 22/06/2026
Ina @inahuppertz.bsky.social and Kathrin @katleppek.bsky.social cordially invite all RNA enthusiasts based in the Rhineland region to attend our series of inspiring in-person talks on RNA-related topics by local and invited speakers. This time on Monday July 13th in the DZNE auditorium in Bonn.
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Plaschka lab @plaschkalab.bsky.social · 18/06/2026
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
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Kurianlab @kurianlab.bsky.social · 18/06/2026
*today at 14:00* Elena Conti Niederrad Lecture, Goethe University, Medical Campus, House 22, Lecture hall 22-1 "The RNA exosome complex: molecular mechanisms of RNA degradation in health and disease"
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Andrii Bugai @abugai.bsky.social · 17/06/2026
Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...
nature.com
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
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Reposted by Volker Boehm
Michaela Müller-McNicoll @mixmue.bsky.social · 17/06/2026
How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out: www.researchsquare.com/article/rs-9...
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CRC1678 @crc1678.bsky.social · 12/06/2026
🚨 Publication Alert 🚨 New review from our #CRC1678 member @riemerlab.bsky.social explores how redox conditions and ROS dynamics shape mitochondrial protein import mapping the redox‑dependent mechanisms linking metabolism, stress, and organelle homeostasis. 🥳 👉 doi.org/10.1002/pro....
doi.org
Redox signals and oxidative stress in the control of mitochondrial protein import
Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sour...
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Reposted by Volker Boehm
RTG 2355 @rtg2355.bsky.social · 05/05/2026
🎉Now OPEN FOR REGISTRATION - join us Sep 14-16 in Giessen for the RTG 2355 International Conference as we explore RNA’s critical functions! Register 👉tinyurl.com/rtg2355conf We have slots for short talks and a poster session in the "Palmenhaus", so submit an abstract to present your own work!
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Reposted by Volker Boehm
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Reposted by Volker Boehm
Marvin Tanenbaum @marvintanenbaum.bsky.social · 13/05/2026
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Akis (Argyris) Papantonis @akispapantonis.bsky.social · 13/05/2026
Our preprint on how variant U1 snRNAs control transcriptional and splicing homeostasis of hiPSCs is now officially out in @natcomms.nature.com and accessible via this link: www.nature.com/articles/s41... This has been the culmination of our work as part of the SPP1935 program funded by @dfg.de 1/n
nature.com
Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells - Nature Communications
Stem cell identity and differentiation require precise gene regulation, yet key regulatory components remain poorly understood. Here, the authors show that variant U1 snRNAs have distinct and essentia...
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Reposted by Volker Boehm
Markus Höpfler @markushopfler.bsky.social · 08/05/2026
We're hiring! Join our growing team at the @crg.eu as a postdoc. Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation. Apply here: recruitment.crg.eu/content/jobs... Please share!
recruitment.crg.eu
Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab | CRG Online Recruitment Portal
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Javier F Caceres @javierfcaceres.bsky.social · 02/05/2026
Our preprint describing the moonlighting functions of SEC13 in NMD and regulation of the UPR is out now in bioRxiv www.biorxiv.org/cgi/content/...
biorxiv.org
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gehringlab.bsky.social @gehringlab.bsky.social · 09/04/2026
academic.oup.com/nar/article/...
academic.oup.com
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Minni Änkö @rnaminni.bsky.social · 25/03/2026
Check out the latest RNA Salon feature highlighting the importance of local community meetings! @rnasociety.bsky.social #RNA www.rnasociety.org/featured-sal...
rnasociety.org
RNA Confluence: a grassroots model for community-driven scientific meetings - RNA Society
Science moves forward through ideas, experiments, and data. But just as often, it advances through conversations. The fleeting discussions at a poster, the hallway chat after a talk, the shared coffee...
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Reposted by Volker Boehm
CRC1678 @crc1678.bsky.social · 17/03/2026
🚨 Publication Alert 🚨 New work from our #CRC1678 members @volkerboehm.bsky.social and Niels Gehring in @narjournal.bsky.social shows that SMG8 and SMG9 act as nonessential but crucial modulators safeguarding the efficiency and resilience of the NMD pathway. academic.oup.com/nar/article/...
academic.oup.com
SMG1:SMG8:SMG9-complex integrity supports efficient execution of nonsense-mediated mRNA decay
Abstract. Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination
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Reposted by Volker Boehm
Jonathan Froehlich @jjfroehlich.bsky.social · 11/03/2026
I started Awesome Life Science Resources: a curated list of resources on work culture, career, and communication for life scientists. Built for PhD students, postdocs, and PIs. Check it out: github.com/jjfroehlich/...
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Torben Heick Jensen @heick.bsky.social · 06/03/2026
Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...
mbg.au.dk
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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König Lab @koenig-lab.bsky.social · 06/03/2026
Want to map protein-RNA interactions? Check out our new iCLIP3 protocol. Featuring steamlined library prep and visualisation of protein-RNA complexes without radioactivity! Bioinformatics workflow on top :) With the Müller-McNicoll and Zarnack labs! @zarnack-group.bsky.social @mixmue.bsky.social
biorxiv.org
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Universität zu Köln @unicologne.bsky.social · 05/03/2026
🔬🧬Fehlerhafte RNA erkennen und zerstören das macht der Nonsense-mediated mRNA Decay Forschende haben nun den zentralen Mechanismus des Kontrollsystems identifiziert. Die zwei Proteine – SMG5 und SMG6 – bilden gemeinsam eine molekulare „Schere“, die die fehlerhafte mRNA zerschneidet. uni.koeln/SVV5T
Drei Personen stehen auf einer Treppe und halten ein rotes Seil mit einem STOP-Schild und bunten Papierelementen. Das Seil wird mir einer Schere zertrennt.
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Michaela Müller-McNicoll @mixmue.bsky.social · 04/03/2026
We are excited to share our new preprint: iCLIP3 — an improved protocol for transcriptome-wide mapping of protein–RNA interactions at single-nucleotide resolution.
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Milo B. Fasken, Ph.D. @milofasken.bsky.social · 27/02/2026
www.nature.com/articles/s41...
nature.com
Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications
Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...
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Tugce Aktas @aktast.bsky.social · 25/02/2026
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.
doi.org
Redirecting
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CRC1678 @crc1678.bsky.social · 25/02/2026
🚨Publication Alert🚨 New work from our #CRC1678 members Niels Gehring and @volkerboehm.bsky.social published in @natcomms.nature.com shows that SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN) enabling efficient mRNA cleavage🧬
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Volker Boehm @volkerboehm.bsky.social · 24/02/2026
How are faulty #RNA degraded? New mechanistic insight into NMD: 1️⃣SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN) 2️⃣ SMG5 completes the SMG6 active site, enabling efficient mRNA cleavage Fantastic collaboration with @labconti.bsky.social 🙏 👉 www.nature.com/articles/s41... 1/n
nature.com
Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications
Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...
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Dmitry Kretov @dmitry-kretov.bsky.social · 06/02/2026
I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/ www.cell.com/molecular-ce...
cell.com
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions
Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...
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CRC1678 @crc1678.bsky.social · 01/12/2025
🚀 New on the #CRC1678 Website! 🌐 Explore Job Opportunities + Fellowships: - Postdoc Position🔬 - Medical Research Fellowship (6 months)👩‍⚕️ - PhD Orientation Fellowship(4 months)🎓 📅 Open year-round, no deadline, open to all! 👉 crc1678.uni-koeln.de/job-opportun...
crc1678.uni-koeln.de
Job Opportunities - CRC1678 - Collaborative Research Center
The CRC1678 offers exciting career opportunities for researchers at different stages of their academic path. Positions within the CRC provide the chance to
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Neville Sanjana @nevillesanjana.bsky.social · 27/11/2025
Looking for some Thanksgiving reading? 🦃🦃🦃 🚨Check out our new preprint on CRISPore-seq!🚨 Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
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EMBL Events @events.embl.org · 14/11/2025
Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼
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CRC1678 @crc1678.bsky.social · 14/11/2025
🚨Speaker Alert 🚨 We’re excited to welcome @landthalerm.bsky.social for the upcoming #CRC1678 Seminar! 🧬 He’ll dive into: "Posttranscriptional Regulation in Cellular Time and Space" 📅 November 25 📍 Auditorium, MPI-Age ⏰ 2:00 PM Explore how RNA dynamics shape cellular behavior across time and space!
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OMühlemann lab @omuhlemann-lab.bsky.social · 13/10/2025
Happy to see this work published! Thanks to everyone who contributed 🙏
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Uwe Ohler @uweohler.bsky.social · 10/10/2025
Dusa’s study is on the cover of this month’s #CellGenomics! Check it out if you haven’t had the chance yet! www.cell.com/issue/S2666-...
cell.com
Issue: Cell Genomics
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Fran Supek @fransupek.bsky.social · 29/09/2025
🛑Guille's @guillepalou.bsky.social no-nonsense 😉 paper is out in @springernature.com Genome Biology! We report variable activity of the NMD pathway (mRNA QC) across tissues & individuals: 🧠less active in the nervous system & in reproductive tissues 🩸more active in digestive tract, muscle, blood
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John Ngo @johntngo.bsky.social · 22/09/2025
🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
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Julius Brennecke @juliusbrennecke.bsky.social · 17/09/2025
wrong bioRxiv link here, sorry. the correct link to the collaboration with Torben and Clemens is: www.biorxiv.org/content/10.1...
biorxiv.org
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...
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Universität zu Köln @unicologne.bsky.social · 12/09/2025
The team of Prof. Dr Niels Gehring @volkerboehm.bsky.social records a comprehensive database that records systematically which genes and gene variants are directly affected by "Nonsense-mediated mRNA Decay" which opens up new avenues for RNA and genome research. The database ➡️ nmdrht.uni-koeln.de
nmdrht.uni-koeln.de
NMDRHT v1.2
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CRC1678 @crc1678.bsky.social · 15/09/2025
🥳 Congratulations from #CRC1678 to @volkerboehm.bsky.social and the Gehring lab for their publication in @cp-molcell.bsky.social on how “Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome” 🧬🧫
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Markus Landthaler @landthalerm.bsky.social · 12/09/2025
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
cell.com
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...
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