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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 12h

Welcome Microsynth – The Swiss DNA Company – as our first Booth Sponsor for RNATX 2027! Join us on 28 January 2027 in Bern. Register: www.conftool.net/chrnat2027 More info: rnatx.ch #RNATX #RNATherapeutics

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 30/09/2026

Meet three confirmed speakers for RNATX 2027: Daniel Blessing (HAYA Therapeutics, keynote), Christian Berk (E.Blum & Co AG) and Felix Gnerlich (Ribocure Pharmaceutical AB). Join us in Bern on 28 January 2027. Register: www.conftool.net/chrnat2027 More info: rnatx.ch #RNATX #RNAResearch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 24/09/2026

Congratulations to Prof. Martin Jinek @martinjinek.bsky.social, for winning two major Swiss awards for his work on CRISPR-Cas9 and genome editing: the Max Cloëtta Prize and the Marcel Benoist Swiss Science Prize. www.news.uzh.ch/en/articles/... (Photo Credit): Daniel Rihs

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 18/09/2026

Registration is now open for the 4th Swiss RNA Therapeutics Summit! Join researchers, clinicians and industry partners in Bern on 28 January 2027 for a full day dedicated to RNA therapeutics. Register: www.conftool.net/chrnat2027 #RNATX #RNAResearch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 28/08/2026

🔬🧪 Scientifica 2026 starts tomorrow! Visit the SIRD booth and discover how RNA helps us understand and treat diseases. 🗓 29. & 30. August 2026 | 🕒 11-17 Uhr | 📍 ETH Zürich | Polyterrasse 🔗 More Infos: buff.ly/gglg1y9 @ethzurich @uzh @stadtzh

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 26/08/2026

Join the 4th Swiss RNA Therapeutics Summit on 28 January 2027 at the University of Bern. Connect with experts from academia, biotech and pharma and explore the latest developments in RNA-based medicines. 📝 Registration opens soon. More information: www.rnatx.ch #RNA #RNATherapeutics

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 20/08/2026

🔊Meet SIRD at Scientifica2026 and discover how RNA helps us understand and treat diseases. 🔬🧪 🗓 29. & 30. August 2026 | 🕒 11-17 Uhr | 📍 ETH Zürich | Polyterrasse 🔗 More Infos: buff.ly/gglg1y9 @ethzurich @uzh @stadtzh

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 11/08/2026

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 23/06/2026

The Swiss Initiative for RNA & Disease (SIRD) is now online. As the successor to NCCR RNA & Disease (2014–2026), SIRD continues to connect RNA researchers across Switzerland and promotes collaboration, education, scientific exchange, and innovation in RNA biology and disease research. 🌐 sird.info

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 30/04/2026

A tiny chemical tweak changed medicine! 💉 Discover how RNA modifications made efficient mRNA vaccines against Covid-19 possible, for which the 2023 Nobel Prize in Physiology or Medicine was awarded. www.youtube.com/watch?v=1SQd... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social

youtube.com

RNA Explained: Hiding in Plain Sight – RNA Modifications Enable Effective mRNA Vaccines

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 29/04/2026

For gene expression,there exist "dimmer switches"!Discover how microRNAs fine-tune protein production in health&disease.For their discovery,the 2024 Nobel Prize in Physiology or Medicine was awarded. www.youtube.com/watch?v=qoUo... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social

youtube.com

RNA Explained: Tiny RNAs, Big Control - microRNAs and Gene Expression

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 28/04/2026

Why do we age? 🧬 Meet telomerase, the molecular machine that rebuilds chromosome ends and its roles in health & disease. For its discovery, the 2009 Nobel Prize in Physiology or Medicine was awarded. www.youtube.com/watch?v=dXLE... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social

youtube.com

RNA Explained: Letting Cells Live Forever – Telomerase and the Maintenance of Chromosome Ends

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 27/04/2026

Reprogramming cells with precision! 🎯 Learn how RNA interference (RNAi) silences specific genes to treat diseases. For its discovery, the 2006 Nobel Prize in Physiology or Medicine was awarded. www.youtube.com/watch?v=rZY1... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social

youtube.com

RNA Explained: Gene Silencing - RNA Interference: Nature's Precision Tool

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 23/04/2026

Our genes come in bits & pieces!🧬Learn how splicing "cuts & pastes" RNA to create different proteins from a single gene, for its discovery the 1993 Nobel Prize in Physiology or Medicine was awarded. www.youtube.com/watch?v=-x7H... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org @rnasociety.bsky.social

youtube.com

RNA Explained: Split Genes – RNA Splicing & Protein Diversity

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 22/04/2026

Preprint by the Leidel, Thiel & Pillai labs with co-1st authors R. Pandey & N. Ebert "Loss of host factor-mediated m6Am methylation of the viral RNA cap impairs SARS CoV-2 replication" @biorxivpreprint.bsky.social doi.org/10.64898/202... @profvolkerthiel.bsky.social @mcm5s2u.bsky.social @unibe.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 21/04/2026

Imagine curing diseases by rewriting the code of life!🧬Discover how CRISPR/Cas9, guided by RNA, acts as molecular scissors to precisely edit genomes, for which the 2020 Nobel Prize in Chemistry was awarded www.youtube.com/watch?v=0rz-... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org

youtube.com

RNA Explained: Rewriting the Code of Life - CRISPR/Cas9 and the Genome Editing Revolution

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 16/04/2026

DNA holds the blueprints, but how are proteins built?Meet the ribosome, a nanomachine.For the studies of it,the 2009 Chemistry Nobel Prize was awarded. Watch the video on YouTube with subtitles in English, French & German: www.youtube.com/watch?v=2txJ... @snsf.ch @unibe.ch @ethz.ch @nobelprize.org

youtube.com

RNA Explained: The Cell's Protein Factory - the Ribosome and Its Structure

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 14/04/2026

Preprint by the Polacek lab and collaborators with first author EunBin Kong "Stress-induced vtRNA1-1 modulates redox homeostasis and ferroptosis susceptibility in hepatocellular carcinoma cells" @biorxivpreprint.bsky.social doi.org/10.64898/202... @unibe.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 13/04/2026

How did life begin?🧬Before DNA & proteins, RNA paved the way for modern life. Learn about "ribozymes". The discoverers of catalytic RNAs were awarded the 1989 Nobel Prize in Chemistry! Watch the video with subtitles in DE, EN & FR: www.youtube.com/watch?v=LjtN... @snsf.ch @unibe.ch @ethz.ch

youtube.com

RNA Explained: The Origin of Life - Ribozymes and the RNA World Hypothesis

YouTube video by NCCR RNA & Disease

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 10/04/2026

RNA Explained Video Series: From CRISPR to Vaccines - 8 RNA Discoveries That Revolutionized Biology!🎬Explore 8 Nobel Prize-winning breakthroughs. They are the final public outreach activity of the NCCR RNA & Disease. Join us on this journey into RNA science! Coming soon! @snsf.ch @ethz.ch @unibe.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 02/04/2026

Paper by the Allain and Jeschke labs with first author Cristina Nguyen "Characterization of flexible RNA binding by tandem RNA recognition motifs through integrative ensemble modelling" in Nucleic Acids Research ( @narjournal.bsky.social) nccr-rna-and-disease.ch/news/article... @ethz.ch #NMR

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 30/03/2026

Review by the Mühlemann Lab with first author Wojciech Teodorowicz "Molecular determinants and therapeutic targeting of stop codon readthrough in eukaryotic translation" @jmolbiol.bsky.social nccr-rna-and-disease.ch/news/article... @omuhlemann-lab.bsky.social @unibe.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 27/03/2026

Publication by the Corn lab and collaborators with first author Lena Kobel " DisTAL-Seq: A TALEN-specific adaptation of DISCOVER-Seq for off-target profiling" in Molecular Therapy Nucleic Acids: nccr-rna-and-disease.ch/news/article... @jcornlab.bsky.social @moltherapy.bsky.social @ethz.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 20/03/2026

🔬 We are pleased to welcome Kamena Kostova (Stowers Institute for Medical Research, USA) as the next speaker in our NCCR RNA & Disease Seminar Series! 🗓️ 23.03.2026 – 16:30 📍 University of Bern, DCBP 🗓️ 24.03.2026 – 11:00 📍ETH Zurich, Hönggerberg For more Info: lnkd.in/ei92r5gg @unibe.ch @ethz.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 17/03/2026

Publication by the Gatfield and Jonas labs with co-first authors Enes Arpa and Michael Taschner "Active Site Assembly by SMG5 as a Mechanism for SMG6 Endonuclease Licencing in Nonsense-mediated mRNA Decay" @jmolbiol.bsky.social nccr-rna-and-disease.ch/news/article... @unil.bsky.social @ethz.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 11/03/2026

We would like to congratulate Sebastian Leidel ( @mcm5s2u.bsky.social ) on receiving the 2026 RNA Society Mid-Career Award! nccr-rna-and-disease.ch/news/article... @rnasociety.bsky.social @unibe.ch @snsf.ch

nccr-rna-and-disease.ch

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Claudia Keller Valsecchi @kellervalsecchi.bsky.social · 02/03/2026

Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...

biozentrum.unibas.ch

Postdoctoral Researcher (ERC-funded project)

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 27/02/2026

🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Danny Nedialkova (Max Planck Institute of Biochemistry, Germany)! 🗓️ 02.03.2026: 16:30 – University of Bern, DCBP 🗓️ 03.03.2026: 16:00 – ETH Zurich, Hönggerberg More info: buff.ly/7Lkx00l... @unibe.ch @ethz.ch @snf-fns.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 20/02/2026

🗓️ We are pleased to announce the NCCR RNA & Disease Seminar Series for the Spring Semester 2025/2026. For more information, visit: lnkd.in/ei92r5gg @unibe.ch @ethz.ch @snf-fns.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 05/12/2025

This weekend, the 37th edition of the Telethon takes place on December 6 & 7, which raises donations for supporting families with children with rare genetic diseases and research on these diseases: telethon.ch/de/

telethon.ch

37. Telethon 6. - 7. Dezember 2024

Die Telethon Action Switzerland Foundation unterstützt Familien, die von seltenen Krankheiten betroffen sind. Unterstützen Sie auch uns!

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 02/12/2025

Congratulations to Raphael Morscher (Associate Member) on becoming an EMBO Young Investigator!

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 02/12/2025

Six days left to submit abstracts, also for talks, and register for the Swiss RNA Workshop 2026! The deadline has been extended to December 8, 2026. swissrnaws.dcbp.unibe.ch

swissrnaws.dcbp.unibe.ch

Swiss RNA Workshop

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Reposted by SIRD - Swiss Initiative for RNA & Disease

Kutay lab @kutaylab.bsky.social · 10/11/2025

We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025... Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!

doi.org

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis

DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...

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Reposted by SIRD - Swiss Initiative for RNA & Disease

FMI science @fmiscience.bsky.social · 04/11/2025

Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...

fmi.ch

One clock, two functions: from daily rhythms to development

Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that...

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 19/11/2025

Preprint by the lab of Jacob Corn & collaborators with first author Moritz Schlapansky "Cell-stereotyped DNA repair outcomes are widespread during genome editing" @biorxivpreprint.bsky.social doi.org/10.1101/2025... @jcornlab.bsky.social @ethz.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 18/11/2025

Publication by the Kutay lab with first author Claudia Gafko "Establishment of an imaging-based screening pipeline for the identification of human ribosome biogenesis inhibitors" in BMC Biol nccr-rna-and-disease.ch/news/article... @kutaylab.bsky.social @ethz.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 17/11/2025

Paper by the Sander & Lee labs & collaborators with co-1st authors Gregory Phelps & Sinem Kurt "Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus" @natmicrobiol.nature.com nccr-rna-and-disease.ch/news/article...

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 14/11/2025

Publication by the Allain lab with co-first authors Johannes Schmoll and Mihajlo Novakovic (also co-corresponding) "Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates" in Nature Chemistry nccr-rna-and-disease.ch/news/article... @ethz.ch @natchem.nature.com #NMRchat

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 07/11/2025

🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Tsutomu Suzuki (University of Tokyo, Japan)! 📅 10.11.2025: 16:30 – University of Bern, DCBP 📅 11.11.2025: 16:00 – ETH Zurich, Hönggerberg More info: nccr-rna-and-disease.ch/education/nc... @unibe.ch @ethz.ch @snf-fns.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 29/10/2025

Publication by the Morscher Lab & collaborators, including the Leidel lab w/ 1st author Sarah Cherkaoui "Reprogramming neuroblastoma by diet-enhanced polyamine depletion" @nature.com NCCR News: nccr-rna-and-disease.ch/news/article... @cherkaos.bsky.social @mcm5s2u.bsky.social @unibe.ch @snsf.ch

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ETH Zurich @ethz.ch · 27/10/2025

Thanks to CRISPR/Cas technology, researchers can precisely edit genetic material to treat hereditary diseases. To achieve this, they need to identify undesirable cuts in the genome at an early juncture. Pioneer Fellow Lilly van de Venn is developing such testing methods. ethz.ch/en/news-and-...

ethz.ch

An ETH spin-off aims to bring gene scissors to the clinic

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 27/10/2025

Paper by the Schneider lab( @schneian.bsky.social ) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @febsj.bsky.social nccr-rna-and-disease.ch/news/article...

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 24/10/2025

🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)! 📅 27.10. 16:30 – University of Bern, DCBP 📅 28.10. 15:00 – ETH Zurich, Hönggerberg 👉 More info: nccr-rna-and-disease.ch/education/nc... @unibe.ch @ethz.ch @snf-fns.ch

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 17/10/2025

Preprint by the Allain lab with co-1st authors Gyula Palfy and Johannes Schmoll "Multiplexed analysis of multicomponent biomolecular condensates without any tag" @biorxivpreprint.bsky.social doi.org/10.1101/2025... @ethz.ch #NMRChat

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Reposted by SIRD - Swiss Initiative for RNA & Disease

Karousis Lab @karousislab.bsky.social · 13/10/2025

🚀 New preprint! We used a human cell-free translation screen (~28 000 compounds) to discover NT-2, a #Fusarium -derived #mycotoxin that blocks human ribosomes. #Cryo-EM at 1.72 Å reveals a link between chemical inhibition and ribosome dormancy. www.biorxiv.org/content/10.1...

biorxiv.org

A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal peptidyl transferase inhibitor

Translation inhibitors are invaluable for probing ribosome function and therapeutic applications, but systematic discovery in human systems is limited by the lack of scalable, screening-compatible cel...

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Reposted by SIRD - Swiss Initiative for RNA & Disease

Grosshans Lab @labgrosshans.bsky.social · 13/10/2025

Watch Lucas' amazing artistic/musical rendition of C. elegans larval development and our work on developmental timing and molting here youtu.be/-hGHYRvw87w and read on his inspiration and challenges below

youtu.be

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 13/10/2025

Publication by the Mühlemann & Chakrabarti Labs w/ 1st author Sofia Nasif "UPF1 shuttles between nucleus and cytoplasm independently of its RNA binding and ATPase activities” @rnajournal.bsky.social nccr-rna-and-disease.ch/news/article... @omuhlemann-lab.bsky.social @unibe.ch

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Reposted by SIRD - Swiss Initiative for RNA & Disease

ETH Zurich @ethz.ch · 10/10/2025

All cells – from mammalian cells to microbes – can follow different biological paths. Whether they grow and divide, specialise, age or die depends on the pathway they take. New findings by researchers at ETH Zurich could help influence a cell’s decisions to target diseases such as cancer.

ethz.ch

Protein condensates determine a cell’s fate

Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.

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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 01/10/2025

Preprint by the Grosshans lab w/ co-1st authors Dimos Gaidatzis, Maike Graf-Landua & Stephen P. Methot "A scheduler for rhythmic gene expression" @biorxivpreprint.bsky.social doi.org/10.1101/2025... @labgrosshans.bsky.social @smethot.bsky.social @fmiscience.bsky.social

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