Researchers at the University of Cologne show that three different proteins work together as a complex to maintain the cell’s quality control / publication in “Nucleic Acid Research”

Abstract. Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination

Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...