Reposted by @tafesselab.bsky.socialMassimo (mirror) @rainmaker1973-m.bsky.social · 12/10/2026Landowner David Hampton planted larch pines in a douglas fir forest in Oregon in the shape of a giant, 300 feet smiley face 🙂 Every autumn the larch pines turn orange and the smiley face stands out. Original post 261416258
tafesselab.bsky.social @tafesselab.bsky.social · 06/10/2026We are searching for a visionary leader to serve as our next Chief Research Officer and Executive Vice President! Come help shape the next chapter of research and discovery at @ohsunews.bsky.social Interested or know someone who would be a great fit? Please share! lnkd.in/gF2cqTaslnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn 011
Reposted by @tafesselab.bsky.socialGiovanni D’Angelo @giodang.bsky.social · 23/09/2026#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas 1011952
Reposted by @tafesselab.bsky.socialJonathan Pruneda @jnpruneda.bsky.social · 22/08/2026WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details. Please share widely and feel free to reach out with any questions! 12623
Reposted by @tafesselab.bsky.socialKimberly Beatty @beattylab.bsky.social · 02/09/2026Work from my team. The more I understand M. abscessus, the more convinced I am that treatment can't ignore its extended spectrum beta-lactamase. That is a very active enzyme!! Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus pubs.acs.org/aidcbc/artic...pubs.acs.orgChemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessusAbstract. The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clin 043
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026Congratulations to everyone involved, especially Scoty Farley and Gaelen Guzman and a huge thank-you to our longtime collaborator, Carsten Schultz! 🎉 000
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026Together, the protocol and repository can make lipid-interactome studies more accessible and accelerate discovery across lipid biology, cell biology, and disease research. 100
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026To help, we created the Lipid Interactome Repository, an open-access platform that centralizes and standardizes proteomics data on lipid–protein interactions. lipidinteractome.orglipidinteractome.orgThe Lipid Interactome Repository – Lipid Interactome Repository 100
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026But discovery is only part of the challenge. How can we share findings and cross-validate results across studies and laboratories? 100
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026Functional lipid probes are changing that. Our protocol offers a roadmap for generating, exploring, and validating lipid–protein interaction data. www.nature.com/articles/s41...nature.comIdentifying lipid–protein interactomes with functional lipid probes - Nature ProtocolsCellular lipids are known to have specific protein interactions. This protocol describes how to study the lipid–protein interactome using multifunctional lipid probes capable of photo-cross-linking an... 100
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026Lipids are far more than building blocks of cellular membranes. Their dynamic interactions with proteins shape cellular function, health, and disease but mapping these interactions remains technically challenging. 100
tafesselab.bsky.social @tafesselab.bsky.social · 04/08/2026To understand what a lipid does, we need to know its partners. Which proteins bind lipids and how can we capture those interactions? Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵 1166
tafesselab.bsky.social @tafesselab.bsky.social · 09/07/2026Excited to share our latest paper where we report an MR1-specific nanobody that blocks MR1-mediated T-cell activation. Congrats to Tim Bates, Corinna from David Lewinsohn’s lab, and thanks to @jburkevic.bsky.social for HDX-MS support! @ohsunews.bsky.social academic.oup.com/jimmunol/art...academic.oup.comAn MR1-specific nanobody capable of blocking MR1T cell activationAbstract. MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cell 063
Reposted by @tafesselab.bsky.socialMikko Taipale @miketilapia.bsky.social · 30/06/2026Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells. 29943
tafesselab.bsky.social @tafesselab.bsky.social · 30/06/2026Job alert! We’re hiring a Postdoctoral Fellow to develop nanobody-based spatial biology approaches to study TB granulomas. Please help spread the word! @microbiologysociety.org @aai.org @ascbiology.bsky.social @ohsunews.bsky.social @embo.org 023
tafesselab.bsky.social @tafesselab.bsky.social · 04/05/2026We’re hiring! Our department is recruiting for a tenure-track faculty position. We seek outstanding candidates working broadly in molecular microbiology, immunology, and host–pathogen interactions. Please share widely! @jnpruneda.bsky.social @rauchlab.bsky.social www.nature.com/naturecareer...nature.comFaculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position. 01619
Reposted by @tafesselab.bsky.socialBella Rauch @rauchlab.bsky.social · 28/04/2026Wan’t to be faculty at a collegial host-pathogen focused department in a beautiful bikable city with amazing food? This link is for you: facultycareers-ohsu.icims.com/jobs/39006/a... 02019
Reposted by @tafesselab.bsky.socialBella Rauch @rauchlab.bsky.social · 23/04/2026🚨Preprint alert ! Alexis Gibson, a @hhmi-science.bsky.social Hannah Grey fellow, reports on our fun collaboration with PNNL. We used standard label-free MS to analyze caspase cleavage products in primary intestinal epithelial cells post inflammasome activation. www.biorxiv.org/content/10.6... 1/2biorxiv.org 193
Reposted by @tafesselab.bsky.socialAndré Nadler @nadlerlab.bsky.social · 23/03/2026It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41... 818864
tafesselab.bsky.social @tafesselab.bsky.social · 05/03/2026PacTB is back in Portland on April 8–9, 2026! West Coast TB folks (Bay Area, WA, Vancouver)—especially grad students & postdocs—please join us! Great chance to present + network. Abstract deadline: TODAY Registration deadline: Apr 1 www.eventbrite.com/e/pactb-2026...eventbrite.comPacTB 2026TB research talks, posters & networking on the West Coast. Meet peers, discover cutting-edge projects, and advance TB research together. 030
tafesselab.bsky.social @tafesselab.bsky.social · 02/03/2026Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social news.ohsu.edu/2026/02/25/n...news.ohsu.eduNew database may unlock potential of lipids in treating, preventing diseaseOHSU scientists lead development of so-called ‘Google maps’ for how lipids interact with proteins inside cells. 0104
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026Huge thanks to my former PhD student and then postdoc Gaelen Guzman - this wouldn’t exist without his drive and craftsmanship. Also, big thanks to Carsten Schultz, @nadlerlab.bsky.social, and @jeremybaskin.bsky.social for their support and contributions. 031
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026Spread the word: Please share/RT so more people can find it. And feedback is welcomed: tell us what you love and how to make it better. 100
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026Want to contribute or have thoughts? This is a living community resource. Submit your dataset via the Data Submission page on the site (or message us directly), and please send ideas for what would make it even better. 100
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026Who’s it for? Anyone curious about lipid function - no need to be expert in lipids. If you want fast, data-driven hypothesis generation (and a shortcut to “what proteins bind my lipid?”), this is for you. 100
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026Why you should care: Lipid–protein interactome studies are exploding, but the data is scattered across papers, inconsistent formats making it hard to compare This database brings it all together - curated, standardized, and cross-study comparable - so the community can actually use these datasets. 100
tafesselab.bsky.social @tafesselab.bsky.social · 24/02/2026 Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...doi.orgThe Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactionsAbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon 13213
tafesselab.bsky.social @tafesselab.bsky.social · 10/02/2026Big career update: I’m honored and humbled to serve as Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University (OHSU). Looking forward to what we’ll build together! @ohsummi.bsky.social @ohsunews.bsky.social 3224
Reposted by @tafesselab.bsky.socialJames Saenz @jamessaenz.bsky.social · 08/07/2025How do lipids shape life? I explore this question in my recent talk for the Build-a-Cell 🦠 seminar series. Thanks to @kateadamala.bsky.social for hosting! Watch it here: youtu.be/JnF7hPCiSbI?...youtu.beBuild-a-Cell seminar James Saenz: Harnessing minimal cells to understand the living membranesYouTube video by Build-a-Cell 06217
tafesselab.bsky.social @tafesselab.bsky.social · 21/01/2026It was fun writing this book chapter on methods to trace #lipid metabolism. Congrats to Alec and Helene for their effort. Thanks to @jeremybaskin.bsky.social for the invitation to contribute this chapter. @ohsunews.bsky.social @ohsummi.bsky.social www.sciencedirect.com/science/chap... 072
Reposted by @tafesselab.bsky.socialEric Topol @erictopol.bsky.social · 17/01/2026Can GLP-1 drugs reduce the incidence of cancer, independent of weight loss? Results from cohort studies are encouraging for many types (Figure) and clinical trials are ongoing nature.com/articles/s43... 515934
tafesselab.bsky.social @tafesselab.bsky.social · 12/01/2026Excited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work! @ohsunews.bsky.social www.sciencedirect.com/science/arti... 195
Reposted by @tafesselab.bsky.socialGiovanni D’Angelo @giodang.bsky.social · 19/12/2025@tafesselab.bsky.social Ronald Schnaar Julie Saba Ashley Cowart @gioelelamanno.bsky.social @nadlerlab.bsky.social Jurgen Seibel Markus Wenk 011
Reposted by @tafesselab.bsky.socialGiovanni D’Angelo @giodang.bsky.social · 19/12/2025Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime 11197
Reposted by @tafesselab.bsky.socialJeremy Baskin @jeremybaskin.bsky.social · 14/12/2025Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland! 0152
Reposted by @tafesselab.bsky.socialAbdou Rachid Thiam @abdourachidthiam.bsky.social · 27/11/2025And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport. Definitely worth a deep read: www.pnas.org/doi/10.1073/...pnas.orgATG2 is a triglyceride transfer protein | PNASBridge-like lipid transfer proteins (BLTPs) are established to function in phospholipid transport between bilayers at organelle–organelle contact s... 03118
tafesselab.bsky.social @tafesselab.bsky.social · 18/11/2025Beautiful work! Congrats @abdourachidthiam.bsky.social and the team! 110
Reposted by @tafesselab.bsky.socialJohn Burke @jburkevic.bsky.social · 05/11/2025Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labsjbc.org 3147
Reposted by @tafesselab.bsky.socialJames Olzmann @olzmannlab.bsky.social · 29/10/2025Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...nature.comFSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell BiologyLange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis. 612338
Reposted by @tafesselab.bsky.socialJeremy Baskin @jeremybaskin.bsky.social · 28/10/2025#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtimeaxial.acs.orgCall for Papers: Lipids and Lipidation | ACS Publications Chemistry BlogThis Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026. 02513
Reposted by @tafesselab.bsky.socialHolthuis Lab @holthuislab.bsky.social · 25/10/2025Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...biorxiv.orgVPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairPerturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,... 24420
Reposted by @tafesselab.bsky.socialGioele La Manno @gioelelamanno.bsky.social · 16/10/2025🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/... 7284108
Reposted by @tafesselab.bsky.socialtafesselab.bsky.social @tafesselab.bsky.social · 12/08/2025Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch. 04216
Reposted by @tafesselab.bsky.socialHeran Darwin, PhD @heran.bsky.social · 07/10/2025We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 02030
Reposted by @tafesselab.bsky.socialJames Saenz @jamessaenz.bsky.social · 24/09/2025🌶️ Lipids bring the heat 🔥 Lipids don’t just shape membranes, they influence cellular metabolism. We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠 Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉 www.biorxiv.org/content/10.1...biorxiv.orgMetabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolismThe cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane... 24114
Reposted by @tafesselab.bsky.socialAndré Nadler @nadlerlab.bsky.social · 21/08/2025Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41... 31346130
tafesselab.bsky.social @tafesselab.bsky.social · 21/08/2025Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team! 141
