iiinova — where your digital self keeps evolving

Sushant Suresh

@sushantsuresh.bsky.social

34 followers 41 following 3 posts

PhD candidate in the John Burke lab at University of Victoria | Structural Biology | HDX-MS | lipid kinases

Posts Replies Media

Reposted by Sushant Suresh

HRMEM @hrmem.bsky.social · 27/11/2025

More structural biology! From the @jburkevic.bsky.social lab with work from @sushantsuresh.bsky.social and @alexlouiseshaw.bsky.social - featuring data collected in our facility! #cryoEM www.jbc.org/article/S002...

jbc.org

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

Phosphatidylinositol 4 kinase IIIα (PI4KIIIα/PI4KA) is an essential lipid kinase that plays a critical role in regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane ...

043

Sushant Suresh @sushantsuresh.bsky.social · 06/11/2025

Final part of my PhD work is now out! We were able to develop a nanobody that inhibits EFR3 mediated PI4KA membrane recruitment. Potential therapeutic idea? Amazing collaboration with different labs using a host of different techniques. @alexlouiseshaw.bsky.social

041

Sushant Suresh @sushantsuresh.bsky.social · 07/08/2025

Great collaborative work where we developed a nanobody based tool to block EFR3 mediated recruitment of PI4KA. A potential therapeutic window maybe? Thanks @alexlouiseshaw.bsky.social for the assist!

011

Reposted by Sushant Suresh

Alexandria Shaw @alexlouiseshaw.bsky.social · 06/08/2025

New preprint from the lab headed up by @sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!

012

Sushant Suresh @sushantsuresh.bsky.social · 06/01/2025

Back from vacation and really glad to share some work from my PhD research. Great collaborative effort @alexlouiseshaw.bsky.social Check out this post from my PI to learn more about Lipid kinase PI4KA and its regulation!

051