Reposted by Charlie EvavoldMiguel Soares @elmiguelche.bsky.social · 03/10/2026gulbenkian.pt/en/news/sele...gulbenkian.ptSelected Proposal for GIMM’s New BuildingThe project submitted by Atelier de Santa Catarina was awarded first place 012
Reposted by Charlie EvavoldJonathan Kagan @jkagan1.bsky.social · 25/09/2026Thank you to Boston Children’s Hospital for highlighting our recent publication, describing: Receptor Free Signal Transduction. www.childrenshospital.org/newsroom/med...childrenshospital.orgReceptor-free signal transduction: Discovery of new method for inflammatory cell communication opens door for therapeutic opportunities in treating autoimmune diseases | Boston Children's HospitalBOSTON, MA [Sept. 23, 2026] — Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated 182
Reposted by Charlie EvavoldRagon Institute of Mass General Brigham, MIT, and Harvard @ragoninstitute.bsky.social · 22/09/2026New in Immunity: The Sokol Lab finds itch-sensing nerve cells can "remember" past allergens and react more strongly next time, even to unrelated ones. This may help explain why allergies build over time. Read more: ow.ly/SXIs50ZPQMb #Allergies #Immunology #Neuroscience 021
Reposted by Charlie EvavoldWaggoner Lab @labwaggoner.bsky.social · 17/07/2026Meeting report @natimmunol.nature.com Innate immunity at the crossroads of protection and pathology: insights from the Aegean www.nature.com/articles/s41...nature.comInnate immunity at the crossroads of protection and pathology: insights from the Aegean - Nature ImmunologyThe 21st International Aegean Conference on Innate Immunity showcased advances that position innate immunity as a multiscale regulatory system integrating environmental, metabolic, epigenetic and gene... 011
Reposted by Charlie EvavoldRagon Institute of Mass General Brigham, MIT, and Harvard @ragoninstitute.bsky.social · 17/07/2026Some immune cells can actually hinder the body's response to threats. New Dang Lab research in Science Immunology points to a new treatment path. Read: ragoninstitute.org/2026/07/dang-lab… #Immunology #FungalInfection 011
Reposted by Charlie EvavoldIva Hafner Bratkovič @ivahb.bsky.social · 14/05/2026Huge congratulations to @elvirab.bsky.social on an outstanding PhD viva! A well-deserved achievement reflecting years of hard work, perseverance, scientific curiosity, and intellectual growth. It has been a privilege to mentor this journey. Excited to see what comes next. 🎓👏 061
Charlie Evavold @synth-immune.bsky.social · 22/04/2026Check out the latest from Eric Dang's lab. @ragoninstitute.bsky.social @harvardmed.bsky.social @jem.org @rupress.org rupress.org/jem/article-...rupress.orgAlternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomasDuring latent pulmonary cryptococcal infection, Zheng et al. show that TH2-driven STAT6 signaling in monocyte-derived myeloid cells suppresses extracellula 073
Charlie Evavold @synth-immune.bsky.social · 20/03/2026Engineering #TCR #catch #bonds for #tumor #immunity. @science.org Chris Garcia @stanforduniversity.bsky.social @hhmi-science.bsky.social Owen Witte @uclastemcell.bsky.social Brian Evavold @utah.edu www.science.org/doi/10.1126/...science.orgOvercoming T cell tolerance to tumor self-antigens through catch-bond engineeringT cells are often weakly responsive to tumor self-antigens because of central tolerance, constraining their ability to eliminate tumors. We exploited mechanical force to engineer a weakly reactive T c... 071
Charlie Evavold @synth-immune.bsky.social · 08/03/2026Our Cell Death in Immunity and Inflammation session was phenomenal today at #ASBMB2026. A pleasure to co-organize this with Cornelius Taabazuing @taabaman.bsky.social. @ragoninstitute.bsky.social @upenn.edu Jianbin Ruan, @katbarnett.bsky.social, Kasia Groburz, & @pedrosvdr.bsky.social 1103
Charlie Evavold @synth-immune.bsky.social · 19/12/2025#Evavold Lab 2025 Holiday memories. It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate. Macrophage Interest Group with Garris lab and Prof. Eric Dang! @ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social 171
Charlie Evavold @synth-immune.bsky.social · 03/11/2025Scooby Doo and the Cell Death Mystery from #Evavold lab @ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social 030
Reposted by Charlie EvavoldThe Francis Crick Institute @crick.ac.uk · 27/10/2025Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud... 02414
Reposted by Charlie EvavoldVijay G. Sankaran @bloodgenes.bsky.social · 29/09/2025www.nih.gov/news-events/...nih.govSecretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer InstituteDr. Letai will serve as NCI’s 18th director. 093
Reposted by Charlie EvavoldRagon Institute of Mass General Brigham, MIT, and Harvard @ragoninstitute.bsky.social · 30/09/2025Meet Lindsey Adams: a scientist, adventurer, and puzzle enthusiast. As a graduate student working in the Lingwood Lab at the Ragon, Lindsey spends her days studying autoimmune diseases and antibody output, diving into the molecular world of protein interactions. #WeAreRagon 062
Reposted by Charlie EvavoldAndreas Linkermann @linkermannlab.bsky.social · 19/08/2025Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.nature.comMultiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules. 43715
Reposted by Charlie EvavoldLudwig Cancer Research @ludwigcancer.bsky.social · 27/06/2025Ludwig @mit.edu Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y #CanSky #OncoSkyyoutu.beTyler Jacks, Ludwig MITYouTube video by Ludwig Cancer Research 041
Reposted by Charlie EvavoldIva Hafner Bratkovič @ivahb.bsky.social · 27/05/2025Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social www.nature.com/articles/s41...nature.comClustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature CommunicationsNLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo... 0219
Charlie Evavold @synth-immune.bsky.social · 08/03/2025Wild. Cell-intrinsic #proteasome derived #defense peptides. @nature.com www.nature.com/articles/s41...nature.comCell-autonomous innate immunity by proteasome-derived defence peptides - NatureProteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that... 010
Reposted by Charlie EvavoldGustavo Monasterio Ocares @gamonasterioo.bsky.social · 05/03/2025Wow! #Chronogenetic is here—an innovative system that harnesses circadian gene control to precisely time the release of drugs and compounds in sync with an individual’s natural biological rhythms. A new era of personalized medicine begins! 🧪 www.nature.com/articles/s41...nature.comA synthetic chronogenetic gene circuit for programmed circadian drug delivery - Nature CommunicationsCircadian medicine, or chronotherapy, seeks to improve drug efficacy based on individuals’ circadian rhythms. Here, the authors combine principles of tissue engineering and synthetic biology to create... 021
Reposted by Charlie EvavoldMike Murphy @mitoredox.bsky.social · 19/02/2025Great to see paper from Alva Casey out today in Nature Metabolism - from her PhD. Well done Alva! doi.org/10.1038/s422...doi.orgPro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature MetabolismCasey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages. 2237
Reposted by Charlie EvavoldJonathan Kagan @jkagan1.bsky.social · 19/02/2025More evidence accumulates that pyroptosis is regulated by ROS after GSDMD cleavage occurs. A beautiful mechanistic study on mitochondrial ROS acting downstream of NLRP3 activation. Kudos to all authors. www.nature.com/articles/s42...nature.comPro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature MetabolismCasey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages. 1133
Reposted by Charlie EvavoldCarl T. Bergstrom @carlbergstrom.com · 08/02/2025Thinking back on all this I better understand the pain I feel to see science under devastating attack here. It’s not just about my livelihood or my university. It’s about my identity. And it’s about a pursuit that I see as standing along with art, literature, and music as among our highest callings. 481484195
Charlie Evavold @synth-immune.bsky.social · 06/02/2025Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade. Out now @nature.com from Carlos Donado and Michael Brenner. @harvard.edu @harvardmed.bsky.social www.nature.com/articles/s41... 020
Charlie Evavold @synth-immune.bsky.social · 30/01/2025#Evavold lab looking sharp for the #Ragon Institute Winter Party last week. 030
Reposted by Charlie EvavoldInstitut Pasteur | 130 years of biomedical research @pasteur.fr · 16/01/2025The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...pasteur.frInstitut Pasteur decides to leave XThe Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ... 411454359
Charlie Evavold @synth-immune.bsky.social · 12/12/2024Evavold Lab and Garris Lab 2024 Holiday Dinner! 040
Reposted by Charlie EvavoldThiago Carvalho @cyrilpedia.bsky.social · 04/12/2024Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st. "Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact." #Immunologymed.emory.eduEmory Max Cooper Prize in Immunology | Emory School of MedicineToggleToggleToggleToggleSearchCloseSearch SearchToggle openToggle closeSub linkSub linkSub linkSub linkSub linkSub linkToggle openToggle ... 14213
Reposted by Charlie EvavoldNeal Silverman @nsilvermanlab.bsky.social · 22/11/2024With lab members Ravi Bharadwaj and Swati Jaiswal, put together this review highlighting the connectivity between transports of cyclic dinucleotides and muropeptide as well as attempted to parse the confusing literature on SLC function in the NOD1/NOD2 pathways: authors.elsevier.com/sd/article/S...authors.elsevier.comScienceDirect.com | Science, health and medical journals, full text articles and books. 1174