Jaundice, caused by the accumulation of bilirubin in plasma, is clinically interpreted as a maladaptive consequence of hemolysis or as indicative of hepatic failure. Drawing on genetic, biochemical, a...

Baertschi et al. demonstrate that microbiota transplantation functions as a selective ecological filter. Although donor species frequently appear, only specific lineages achieve stable strain integrat...

Fearless molecular biologist who revealed the workings of antibodies and memories.

Heme, an iron-containing cofactor, is synthesized in mitochondria by an eight-enzyme pathway. Although cells were thought to manage heme autonomously, more than 1000 proteins contribute to its product...

We offer a multidisciplinary, transversal and integrated Master training from the bench to the bedside grounded on the four major areas of biomedical research: cell biology and cancer, neurosciences, ...

Diverse voices overcome scientific challenges

From supercharged cancer cells to the first personalized gene-editing therapy, last year was full of scientific advances

Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...

The 2026 Gordon Research Conference on Immunochemistry and Immunobiology will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.

Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger

How storytelling is used as "investigation".

A team of researchers led by Karina Xavier has uncovered a promising new live biotherapeutic agent that may redefine how the medical field approaches microbiota-based therapies.

Jaundice, a condition characterized by elevated levels of circulating bilirubin, is an adaptive response to malaria sustained through bilirubin production by biliverdin reductase A (BVRA). Beyond its ...

Single-cell transcriptomics is transforming biology, uncovering hidden cell states, dynamic transitions, and intricate interactions across systems from immunity to cancer. Yet as these technologies s…

imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital parameters within physiological ranges. This study characterizes how mouse monocyte-derived macrophages...

Substância controla doença de várias maneiras; pesquisador espera que, no futuro, seja possível usar descoberta em terapias

A buildup of unconjugated bilirubin may be a protective response to malaria

Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an adaptive or maladaptive r...

Nature - Hear the biggest stories from the world of science | 04 June 2025

<p>Tal como na malária, também não existe uma vacina contra o fascismo. Apenas a educação, a liberdade, a justiça e a empatia nos podem proteger</p>

A preprint by Martins, Blankehaus et al. highlights an important role for monocyte-derived macrophages in iron homeostasis and its control of systemic energy metabolism.

Complement exposure induces programmed cell death of red blood cells due to the intracellular activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal damage and prevents...

Dr. Carlo Testa explains why understanding historical Fascism is critical to resisting the many forms of Fascism that are arising today.