Haploinsufficiency of A20 (HA20) is an immune dysregulation disorder caused by loss-of-function TNFAIP3 mutations. This international multicenter study aimed to delineate its clinical spectrum, geneti...

A series of recently published studies show why some people's immune systems are unable to fight off the potentially deadly Valley Fever.

Glucocorticoids (GCs) are lifesaving medicines prescribed to treat inflammatory diseases. Macrophages play a pivotal role during hyperinflammation and cytokine storm, two processes intricately linked to NLRP3 inflammasome activation. Macrophages ...

A broader scope for the Journal of Human Immunity.

The immune dysregulation in SARS-CoV-2–related multisystem inflammatory syndrome in adults (MIS-A) is not fully characterized. In this work, Khoryati et al

CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...

In vivo studies in chickens demonstrate that the activation of the NLRP3 inflammasome is a key driver of renal injury during infectious bronchitis virus (IBV) infection. Pharmacological inhibition of ...

Kilic et al. reported a child with a homozygous TBK1 mutation previously linked to autoinflammation, suggesting its role in recurrent severe viral infectio

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

New discoveries in the field of human monogenic immune diseases highlight critical genes and pathways governing immune responses. Here, I describe how the ~500 currently defined human inborn errors of...

Our retrospective study highlights that acute use of nirmatrelvir/ritonavir significantly reduces the risk of post-acute sequelae of SARS-CoV-2 infection (

Pediatric Research - Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease

npj Biofilms and Microbiomes - Gut microbiota alterations are linked to COVID-19 severity in North African and European populations

Summary: Gut immunity may play a critical role in the initiation and persistence of multisystem inflammatory syndrome in children, inflammatory bowel disease and Kawasaki disease. Understanding this c...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an ongoing public health challenge as a cause of acute illness and post-acute sequelae of COVID-19 (PASC, or long COVID). Our stud...

Research reveals molecular-level details into the syndrome’s lasting effects on inflammation and immune response in people with ME/CFS.

First-in-human study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of BGE-102, an orally available small molecule with potential...

A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.

Systemic AutoInflammatory Diseases (SAIDs), AutoImmune Diseases (AIDs), and Primary Immune Deficiencies (PIDs) were formely considered independent, ev…

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

This article describes the ethical dilemmas encountered by clinical immunologists in the evaluation of an inborn error of immunity. Potential sources of he

Objective Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in NLRP3. Although somatic NLRP3 mosaicism is increasingly recognized, it ...

Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...

In this study, Jung et al. investigate the effect of excessive NLRP3-mediated neuroinflammation on synaptic functions and behaviors using Nlrp3D301N-conditional knockin mice. Strikingly, excessive NLR...

Sylvain et al. identified NK7-902, a potent NEK7 degrader. While NK7-902 effectively degrades NEK7 in human and murine systems, inhibition of NLRP3 activity varies by context. This study deepens insight into NEK7’s role in the NLRP3 inflammasome and raises questions about the therapeutic potential of NEK7 degraders for NLRP3-driven diseases.

In lieu of traditional genetic variant testing approaches, an approach using scalable variant classification in primary human T cells with a clinically relevant readout can inform rapid diagnosis and treatment of inborn errors of immunity.

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Open access, peer reviewed, and co-owned, the Journal of Human Immunity represents a new business model in scientific publishing.

At the outset of the COVID-19 pandemic, health care practitioners and families with young children were relatively relieved to learn that children with acute SARS-CoV-2 infections were generally predi...