Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have shaped the composition of human skeletal tissue.

Resource supply is generally considered a dominant driver of microbial diversity. Here, using a four-species bacterial consortium, we asked whether...

A comparative multi-omic study finds that family-biased repertoires of short regulatory DNA motifs remain conserved over greater evolutionary distances than do the motif sets and co-occurring motif pa...

This Review discusses how rare-disease-causing variants in the noncoding genome impact gene regulation, why these examples are so few and how new approaches could accelerate discovery of noncoding var...

Abstract. Insertion sequences (ISs) are widespread prokaryotic transposable elements, often regarded as genomic parasites that primarily cause deleterious

Lund University welcomes applicants with different backgrounds and experiences. Gender equality, equal opportunities and diversity are fundamental principles in all parts of the University’s activit

Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d

High-dimensional data are visualized through representation on tree structures.

Abstract. Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as d

Abstract. Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo representations that explore a much larger space of possible for

Housekeeping genes maintain robust expression across cell types despite dynamic transcription factor fluctuations, yet their haploinsufficiency is associated with many tissue-specific developmental di...

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

Living systems rely on gene regulatory circuits to respond to environmental change. Such circuits often act as molecular switches: OFF in the absence of a cue, and ON in its presence. We do not know h...

Das Programm «IMPULS: LEHRE» fördert innovative Lehrprojekte an der Uni Bern. Eines davon ist die «Schatztruhe».

Abstract. Climate change urges us to better understand and predict evolutionary responses to temperature shifts. Hybridization, by increasing genetic varia

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Promoters emerge three times more readily from random DNA than from genomic DNA.

Promoters emerge three times more readily from random DNA than from genomic DNA.