Sign in

Gilles FISCHER

@gillesfischer.bsky.social
358 followers 384 following 56 posts

Evolution, Genomics, Yeast

PostsRepliesMedia
Reposted by Gilles FISCHER
Yeast Journal @yeast-journal.bsky.social · 15/09/2026
Many congratulations to Rosalie Wouters from Delft University for winning the best poster award sponsored by the #Yeast journal at the 9th Conference on Physiology of Yeasts and Filamentous Fungi @pyff-9.bsky.social in Valencia 🎉🎉🎉 The prize was awarded by our editor-in-chief @litinice.bsky.social
0156
Reposted by Gilles FISCHER
Nikos Vakirlis @vakirlis.bsky.social · 19/08/2026
Really proud of this piece, led by @timothyfuqua.bsky.social , finally published in GBE! Tim's post perfectly explains what it hopes to achieve.
1106
Reposted by Gilles FISCHER
Simone Mozzachiodi @simonemozzachiodi.bsky.social · 13/07/2026
Happy to share our story on the impact of #chemicals on #fungi and #pollinators. We started from a broad screening of agrochemicals toxicity and ended up using #laboratoryevolution to mitigate the negative effect of a common pesticide on #pollinators and their #microbiomes. See below Kiran's post 👇🏻
1143
Reposted by Gilles FISCHER
Nils Homer @nilshomer.com · 28/06/2026
🚀 new bwa-mem3 is out. Why use it? - 🏛️keep using a bwa-mem variant (avoid revalidation/reprocessing) - 🚅 1.7x faster/20% less memory than bwa-mem2 - 🧬native methylation support (asymmetric scoring) - ✅ matches bwa-mem2 output - 👊opt-in knobs to go even 2x faster bwa-mem3.readthedocs.io/en/latest/
bwa-mem3.readthedocs.io
Home - bwa-mem3
Accelerated short-read alignment, derived from bwa-mem2
14219
Reposted by Gilles FISCHER
EMBL Events @events.embl.org · 23/06/2026
🚨 Abstract submission deadline is approaching for #EMBOEvoEco! If you want to be part of the EMBO Workshop focusing on uncovering the mechanistic foundations of ecological and evolutionary processes. Submit your abstract by 30 June: s.embl.org/eae26-01-bl
042
Gilles FISCHER @gillesfischer.bsky.social · 23/06/2026
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus
Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.
030
Reposted by Gilles FISCHER
Toni Gabaldón @tonigabaldon.bsky.social · 10/06/2026
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
10278135
Reposted by Gilles FISCHER
Caiti Smukowski Heil @caitismuheil.bsky.social · 04/05/2026
Super excited to share our lab's work led by PhD student Margot Ruffieux on domestication of Saccharomyces cerevisiae, with a focus on sourdough and baking associated yeast! 🍞
biorxiv.org
12711
Reposted by Gilles FISCHER
Chloé Haberkorn @chloehbk.bsky.social · 06/06/2026
New paper out in Evolution 🧫🧬 doi.org/10.1093/evol... with a pretty big crew & @stelkens.bsky.social ! Story started over 20 years ago, fun to jump in late and help wrap it up :)
doi.org
Adaptive Benefits of Hybridization in Saccharomyces Yeast are Constrained by Genomic Background and Depend on Temperature
Abstract. Climate change urges us to better understand and predict evolutionary responses to temperature shifts. Hybridization, by increasing genetic varia
1249
Reposted by Gilles FISCHER
Rike Stelkens @stelkens.bsky.social · 10/06/2026
Please join us at this #EMBOEvoEco Workshop on 6-9 October 2026. It is hands down one of my (if not THE) favourite conferences with a real community feeling and it's great for networking! Also, the catering is excellent. :)
1177
Reposted by Gilles FISCHER
The Rokas Lab at Vanderbilt University @rokaslab.bsky.social · 09/06/2026
Want to gain mechanistic insights on major outstanding questions in #ecology and #evolution? Join us 6-9 October 2026 for the #EMBOEvoEco Workshop at @events.embl.org in beautiful Heidelberg, Germany Abstract submission deadline is June 30 - submit one now! www.embl.org/about/info/c...
Organizer, Keynote Speaker and Invited Speaker Lineup
0156
Gilles FISCHER @gillesfischer.bsky.social · 09/06/2026
Don't miss the abstract submission deadline Jun 30, 2026 for the excellent EMBO Evo Eco conference! www.embl.org/about/info/c...
embl.org
Molecular mechanisms in evolution and ecology
000
Reposted by Gilles FISCHER
Saccharomyces Genome Database @yeastgenome.bsky.social · 06/06/2026
🚀 Ethanol boost breakthrough: Overexpressing #Yeast MSS11 transcription factor increases ethanol production 24% by coordinating carbon metabolism and stress resistance. Dual mechanism enhances both fuel output and cellular robustness 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...
033
Gilles FISCHER @gillesfischer.bsky.social · 04/06/2026
www.science.org/doi/10.1126/...
science.org
A provocative view of evolution turns 50
The Selfish Gene continues to challenge readers half a century later
020
Reposted by Gilles FISCHER
Joel S. @joelhs.bsky.social · 03/06/2026
He is risen: www.cbsnews.com/news/oetzi-t...
cbsnews.com
Scientists find yeast in frozen mummy's guts, use it to make sourdough bread
More than 5,300 years ago, Oetzi the Iceman was strolling through the Alps on the border of Austria and Italy when he was killed by an arrow in the back.
44429112
Reposted by Gilles FISCHER
Yeast Journal @yeast-journal.bsky.social · 22/05/2026
In this editorial that marks #Yeast 's 40th anniversary, our former editor Stephen Oliver walks us through the journal's history, from its very first steps to the change of the editorial board in more recent years, and wishes the best for Yeast's future 🙂 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Yeast at Forty
Click on the article title to read more.
0104
Gilles FISCHER @gillesfischer.bsky.social · 18/05/2026
Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity: Current Biology www.cell.com/current-biol...
cell.com
Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity
Bircham et al. show that traditional European farmhouse brewing preserves genetically diverse, sexually competent Saccharomyces cerevisiae populations that are genetically and phenotypically distinct ...
051
Gilles FISCHER @gillesfischer.bsky.social · 05/05/2026
go.nature.com/4eizPS8
go.nature.com
Learning the rules of metabolic innovation in yeast evolution
010
Reposted by Gilles FISCHER
Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
7448197
Gilles FISCHER @gillesfischer.bsky.social · 23/04/2026
Extensive novel genetic diversity in indigenous peoples of America www.nature.com/articles/s41...
nature.com
The evolutionary history and unique genetic diversity of Indigenous Americans - Nature
Analysis of 128 high-coverage Indigenous American genomes shows extensive diversity shaped by several South American dispersals, ancient Australasian admixture, archaic introgression and long-term ada...
010
Reposted by Gilles FISCHER
Judith Berman @judithberman11.bsky.social · 12/04/2026
open.substack.com/pub/ofthebra...
open.substack.com
I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.
Attacks on science and immigrants are destroying America.
031
Reposted by Gilles FISCHER
Kristoffer Krogerus @suregork.bsky.social · 27/03/2026
In our recent study, we created over 1000 intraspecific yeast hybrids by crossing genetically diverse strains and tested how well they grow under harsh industrial conditions such as high ethanol, salt, and organic acids. enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com
Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids
A large set of intraspecific yeast hybrids was constructed using two strategies that yielded series of hybrids with variable ploidy. Phenotyping of the hybrids was carried out in high-stress media to....
1127
Gilles FISCHER @gillesfischer.bsky.social · 31/03/2026
Super nice story, a must 5min read communities.springernature.com/posts/why-an...
communities.springernature.com
Why animals (and predatory bacteria) outsource costly amino acids
A simple teaching question — why some amino acids are essential — revealed a striking energy-based pattern. Convergent evolution in predatory bacteria and a new statistical framework helped us show th...
020
Gilles FISCHER @gillesfischer.bsky.social · 30/03/2026
journals.plos.org/plosbiology/...
journals.plos.org
Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments
Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...
020
Reposted by Gilles FISCHER
Maitreya Dunham @maitreya.bsky.social · 27/03/2026
Now published! Short title could be: How to do genetics with dead things. A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus doi.org/10.17912/mic...
doi.org
A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus. | microPublication
1197
Gilles FISCHER @gillesfischer.bsky.social · 25/03/2026
thetyee.ca/News/2026/03...
thetyee.ca
How ‘Fire Fungi’ Help Put Burnt Landscapes Back Together | The Tyee
Before plants and animals recolonize after a wildfire, fungi get to work.
010
Gilles FISCHER @gillesfischer.bsky.social · 25/03/2026
A 50 kb bacterial genome www.nature.com/articles/s41...
nature.com
Convergent extreme reductive evolution in ancient planthopper symbioses - Nature Communications
Symbiotic bacteria can have exceedingly small genomes. This study finds that ancient bacterial symbionts of planthoppers have repeatedly evolved the smallest known genomes, losing most biosynthetic fu...
030
Reposted by Gilles FISCHER
Sissel Jentoft @jentoft.bsky.social · 25/03/2026
Finally is the paper where we present the unique genomic architectures of the Arctic codfishes out!! Nice work by @gadus-sivus.bsky.social and co-authors … @biovitenskap.bsky.social @unioslo-cees.bsky.social link.springer.com/article/10.1...
link.springer.com
Rapid genome modifications including chromosomal fusions and large-scale inversions are key features in Arctic codfish species - Genome Biology
Background Genome evolvability involves activation of transposable elements (TEs) that result in novel genomic rearrangements, including translocations, deletions, duplications, as well as larger stru...
13515
Reposted by Gilles FISCHER
The Independent @the-independent.com · 25/03/2026
New Covid variant has been identified and is already spreading in 25 states
trib.al
New Covid variant has been identified and is already spreading in 25 states
Researchers say the strain could evade protection from current Covid shots
46663
Reposted by Gilles FISCHER
Rachel Maddow @maddow.bsky.social · 22/03/2026
I know this has circulated with alacrity recently, so you may have already seen it, but if you haven't... WOW BOY HOWDY it's the most useful thing. Thank you cardcatalogforlife.substack.com -- this is a very very very helpful public service: cardcatalogforlife.substack.com/p/google-has...
cardcatalogforlife.substack.com
Google Has a Secret Reference Desk. Here's How to Use It.
40 Google features to find exactly what you need, the alternative search engines that do things Google won't, and the reference desk framework underneath all of it.
287116694865
Gilles FISCHER @gillesfischer.bsky.social · 22/03/2026
Encouraging and full of hope: this study shows that even species on the brink of extinction can regain lost genetic diversity and recover over time. www.science.org/doi/10.1126/...
science.org
Escaping bottlenecks: The demographic path to genetic recovery in koalas (Phascolarctos cinereus)
Population bottlenecks can lead to evolutionary dead ends by eroding genetic diversity and intensifying inbreeding. Although theory predicts possible escape routes, direct observations of this process...
041
Reposted by Gilles FISCHER
PLOS Biology @plosbiology.org · 20/03/2026
Polarized growth in #Spombe needs Cdc42, but what role does it play in cell fusion? @sajjitasaha.bsky.social @sophiemartinlab.bsky.social &co show that mitotic polarized growth responds linearly to Cdc42 levels, but mating involves a sharp switch-like response @plosbiology.org 🧪 plos.io/4bvGIhb
Mating fission yeast cells expressing Myo52-GFP (green), Cdc42-mCherrySW (Magenta) and mTagBFP2 expressed in P-cells (cyan). The cells fail to fuse, as shown by the cyan fusion marker confined to one of cell compartment. Image credit: Sajjita Saha.
0132
Gilles FISCHER @gillesfischer.bsky.social · 21/03/2026
www.nytimes.com/2026/03/20/s...
nytimes.com
David Botstein, Gene-Mapping Pioneer, Dies at 83
011
Reposted by Gilles FISCHER
Yeast Journal @yeast-journal.bsky.social · 02/03/2026
ANNOUNCEMENT: The webpage for the upcoming yeast meetings of 2026 has recently been updated. Have a look at it to find out which exciting #yeast #conferences are ahead!!! 😀 onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
Yeast | Microbiology Journal | Wiley Online Library
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
0108
Reposted by Gilles FISCHER
Yeast Journal @yeast-journal.bsky.social · 05/03/2026
In the latest #Yeast review article, A. Kiely, F. O'Halloran, P. Young, N. F. Lowndes, @murielgalway.bsky.social and K. Finn discuss the latest advances in understanding the versatile role of Rad9 in the DNA Damage Response in Saccharomyces cerevisiae 🧬 onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae
To maintain the integrity of the genome, cells have evolved a complex signalling system, termed the DNA damage response (DDR), which detects DNA damage and promotes DNA repair. To date, over 600 prot....
095
Gilles FISCHER @gillesfischer.bsky.social · 21/02/2026
📢 In our new study, we identify the predominant natural route to polyploidy in S. cerevisiae. Stepwise polyploidization operates through iterative cycles of events termed "Sporulate–Endoreplicate–Mate" (SEM). Really excellent work led by @cintiagomez.bsky.social 👏 www.biorxiv.org/content/10.6...
biorxiv.org
1125
Reposted by Gilles FISCHER
Max Haase @maxhaase.bsky.social · 18/02/2026
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
nature.com
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
9236119
Reposted by Gilles FISCHER
Craig Kaplan @triggerloop.bsky.social · 16/02/2026
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
science.org
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
411953
Reposted by Gilles FISCHER
Brooke Weinstein @brookesloci.bsky.social · 07/02/2026
Hello Bluesky! Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates? We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits. www.pnas.org/doi/10.1073/... #evobio #PNAS
24718
Gilles FISCHER @gillesfischer.bsky.social · 14/02/2026
www.nature.com/articles/s41...
nature.com
Inducing novel endosymbioses by implanting bacteria in fungi - Nature
A study presents an approach to establish and track a new endosymbiotic partnership by implanting bacteria in a non-host fungus and shows that stable inheritance of the implanted bacteria is possible ...
030
Gilles FISCHER @gillesfischer.bsky.social · 14/02/2026
www.science.org/doi/10.1126/...
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
010
Reposted by Gilles FISCHER
PLOS Biology @plosbiology.org · 03/02/2026
#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz
Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.
0156
Reposted by Gilles FISCHER
Lars Eicholt @lacholt.bsky.social · 28/01/2026
Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
nature.com
Emergence and evolution of protein-coding de novo genes - Nature Reviews Genetics
De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes are identified, the mechanist...
36229
Reposted by Gilles FISCHER
Kyle T David @kylethedavid.bsky.social · 28/01/2026
Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬 www.sciencedirect.com/science/arti...
sciencedirect.com
Discovery of additional ancient genome duplications in yeasts
Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…
14317
Reposted by Gilles FISCHER
Dmitri Petrov @petrovadmitri.bsky.social · 29/01/2026
Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
grc.org
14839
Reposted by Gilles FISCHER
Yeast Journal @yeast-journal.bsky.social · 27/01/2026
The deadline for the submission of papers to the special issue on the International Yeast Meetings of 2025 has been extended to 31 March. Papers should be connected to one of the meetings listed below. Hurry up and don't miss this chance! More information at: onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
Yeast Call for Papers: International Yeasts Meetings of 2025
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
12813
Reposted by Gilles FISCHER
EMBL @embl.org · 22/01/2026
EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond. We extend our deepest condolences to his family, friends, and colleagues. www.embl.org/news/people-...
111044
Reposted by Gilles FISCHER
Alex Crits-Christoph @acritschristoph.bsky.social · 20/01/2026
Sad to hear that Oxford Nanopore wants to discontinue the P2Solo later this year in favor of the P2i (the very pricey P2Solo that comes with a GPU to do the basecalling in it) It feels like such a big step in the wrong direction. They are a great sequencing company, not a great GPU upseller...
community.nanoporetech.com
nanoporetech-customers - Sign In
42614
Reposted by Gilles FISCHER
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón) @gabaldonlab.bsky.social · 18/01/2026
📣 #paper "Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen" Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus) link.springer.com/article/10.1...
2114
Gilles FISCHER @gillesfischer.bsky.social · 18/01/2026
Last paper in collaboration with Zhou XU. We explored the natural telomere length diversity in S. cerevisiae and found that ploidy level, and subtelomere structure drive telomere length variation. Higher ploidy levels lead to telomere elongation! genome.cshlp.org/content/earl...
genome.cshlp.org
Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
073