Tendons are transitional tissues linking muscle to bone, enabling locomotion and fine motor control. The cellular biology across the Achilles tendon unit is poorly understood, yet critical for interpr...

npj Regenerative Medicine - CYR61 delivery promotes angiogenesis during bone fracture repair

Vertebrate skeletogenic cells of different embryonic origins are distinct cell types, based on their lineage-specific gene regulatory logic that specifies them, and the potential for individualized ev...

Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...

We often hear that NDORMS is particularly strong in bringing together different research disciplines. Associate Professor Sarah Snelling and three of her current and former students share their experi...

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which a substantial increase in knowledge has been achieved over the last year. It covers many different topics, however, a ...