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Frank Zaucke

@fzaucke.bsky.social
395 followers 275 following 25 posts

Head of a reserach lab at the University Hospital Frankfurt, Goethe University. Interested in the role of the #cartilage and #bone #extracellular #matrix in common and rare skeletal diseases, in particular #osteoarthritis and #osteogenesis imperfecta

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Reposted by Frank Zaucke
CHANGE ECM MSCA Doctoral Network @change-ecm.bsky.social · 13/11/2025
Our abstract this week comes from Chantal Fayad who is researching the role of FGF signalling in hypochondroplasia and ageing at @institutimagine.bsky.social with Prof Laurence Legeai-Mallet. Please contact Chantal if you'd like to know more! www.linkedin.com/in/chantal-f... #MSCA_DN #FGF #ageing
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Reposted by Frank Zaucke
CHANGE ECM MSCA Doctoral Network @change-ecm.bsky.social · 06/11/2025
This week's abstract is by Matteo Signor who is studying the link between the ageing autonomic nervous system and IVD degeneration, supervised by @zsuzsajenei-lanzl.bsky.social at @goetheuni.bsky.social. Send Matteo a message to find out more! www.linkedin.com/in/matteo-si... #IVD #ageing #MSCA_DN
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Reposted by Frank Zaucke
CHANGE ECM MSCA Doctoral Network @change-ecm.bsky.social · 30/10/2025
Our next @change-ecm.bsky.social abstract is by Giulio Gatto, a PhD candidate from @goetheuni.bsky.social. Giulio is investigating OA-associated changes in cartilage ECM under the supervision of @fzaucke.bsky.social. Please message Giulio if you'd like to know more. www.linkedin.com/in/giulio-ga...
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Frank Zaucke @fzaucke.bsky.social · 11/09/2025
Fantastic line-up of speakers! If you are interested in matrix research, please come to Heidelberg🤗
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Frank Zaucke @fzaucke.bsky.social · 11/08/2025
The final version of our recent review on challenges in the development of DMOADs is available here👍 #osteaorthritis rdcu.be/eAflJ
rdcu.be
Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs – a more refined perspective
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Reposted by Frank Zaucke
Journal of Cell Science @jcellsci.bsky.social · 16/07/2025
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/... #OpenAccess
Figure showing the building MatriComDB, an omnibus database of matrisome protein interactions.
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Frank Zaucke @fzaucke.bsky.social · 16/06/2025
Great meeting! Hope to see many of you there👇
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Reposted by Frank Zaucke
Goethe-Universität Frankfurt @goetheuni.bsky.social · 13/06/2025
🚨 1 Milliarde Euro würde fehlen – was bedeutet das für Forschung & Lehre an hessischen #Hochschulen? Unser Präsident Prof. Dr. Enrico Schleiff findet klare Worte zum aktuellen Entwurf des Hochschulpakts. Jetzt ansehen und teilen! #Hochschulpakt #GoetheUni #Hessen
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Frank Zaucke @fzaucke.bsky.social · 06/06/2025
Please have a look at this recent review on #osteoarthritis. Thanks to Mario Rothbauer and the entire team for letting me contribute! rdcu.be/epH7q
rdcu.be
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research | Arthritis Research & Therapy
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Frank Zaucke @fzaucke.bsky.social · 14/05/2025
Excited to share our latest work on a novel mutation in a gene that causes non-classical OI👇 url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480
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Frank Zaucke @fzaucke.bsky.social · 01/04/2025
Please have a look at and enjoy reading the latest publication I have contributed to😉
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Frank Zaucke @fzaucke.bsky.social · 12/03/2025
Now, the same group (including myself😉) presents data on how other cartilage biomarkers are changed as a result of immobilization. Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...
sciencedirect.com
Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals
To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartil…
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Frank Zaucke @fzaucke.bsky.social · 12/03/2025
In 2024, the effect of immobilization (by a 21 day bed rest) on the degradation of collagen II was published in the journal Osteoarthritis and Cartilage by Liphardt et al. Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...
sciencedirect.com
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals
To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker…
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Frank Zaucke @fzaucke.bsky.social · 28/02/2025
Honoured to be invited to such a fantastic meeting!
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Frank Zaucke @fzaucke.bsky.social · 22/01/2025
I'll be there👇😉
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Frank Zaucke @fzaucke.bsky.social · 18/01/2025
Are you attending the annual meeting of the Orthopaedic Research Society #ORS2025 meeting in Phoenix? If so👇
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Frank Zaucke @fzaucke.bsky.social · 16/01/2025
With the following link authors.elsevier.com/c/1kPnD3Im5h... you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.
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Frank Zaucke @fzaucke.bsky.social · 14/01/2025
Amazing study!👇
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Frank Zaucke @fzaucke.bsky.social · 17/12/2024
In case you are interested in the role of the #ECM in inherited skeletal disorders other than #osteogenesis imperfecta like e.g. #Marfan or #Ehlers-Danlos, #achondroplasia, #ciliopathies: watch out for this book that will be published soon (January 2025)!
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Frank Zaucke @fzaucke.bsky.social · 14/12/2024
🚨publication alert🚨 Open Access! Please have a look at our latest review: doi.org/10.1515/jpem...
doi.org
Osteogenesis imperfecta: shifting paradigms in pathophysiology and care in children
The formation of functional bone requires a delicate interplay between osteogenesis and osteolysis. Disturbances in this subtle balance result in an increased risk for fractures. Besides its mechanica...
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Frank Zaucke @fzaucke.bsky.social · 04/12/2024
Spectacular view of #Cologne yesterday evening
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Frank Zaucke @fzaucke.bsky.social · 27/11/2024
A very dark bluesky yesterday evening in Frankfurt
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Frank Zaucke @fzaucke.bsky.social · 22/11/2024
A more detailled summary of my research interests/activities....generated here: scholargoggler.com
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Frank Zaucke @fzaucke.bsky.social · 21/11/2024
My first post on bsky☺️ The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage www.oarsijournal.com/article/S106...
oarsijournal.com
Osteoarthritis year in review 2024: Biology
Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which a substantial increase in knowledge has been achieved over the last year. It covers many different topics, however, a ...
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