Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 04/12/20258/ POZ magazine: www.poz.com/article/comb...poz.comCombination Immunotherapy May Help T Cells Fight HIVAn HIV vaccine plus broadly neutralizing antibodies and an immune-stimulating drug helped control HIV after stopping antiretrovirals. 001
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 03/12/20257/ San Francisco Examiner: www.sfexaminer.com/news/public-...sfexaminer.comHIV treatment in small UCSF study shows promiseResearchers tout effectiveness of method that wouldn’t require lifetime of medication 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20256/ Nature News and Views: www.nature.com/articles/d41...nature.comAntibodies and T cells join forces for sustained HIV remissionTwo studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a person stops taking antiviral pills. 221
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20255/ The Seattle Times: www.seattletimes.com/seattle-news...seattletimes.comPath to HIV cure includes Seattle scientistsTwo new studies provide insights into a possible cure for HIV, and feature the work of researchers from the UW and Fred Hutchinson Cancer Center. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20254/ UCSF: www.ucsf.edu/news/2025/12...ucsf.eduLong-Term HIV Control: Could this Combination Therapy Be the Key?UCSF researchers have made strides toward an HIV cure, showing experimental immunotherapy can help control the virus without long-term antiretroviral therapy (ART). In a small study, 7 of 10 participa... 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20253/ Science: www.science.org/content/arti...science.orgHow some treatments can lead to a ‘functional cure’ for HIVSpecific class of immune cells help keep virus at bay for months or years—even in the absence of drugs 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20252/ The Washington Post (gift link): www.washingtonpost.com/science/2025...washingtonpost.comSmall study shows a promising path toward HIV cureAntiretroviral drugs that prevent HIV and keep it in check have been transformative, but a cure has been a long-sought goal. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/2025Thoughtful coverage of our study from various outlets. 🧵 1/ The SF Chonicle: www.sfchronicle.com/health/artic...sfchronicle.com‘Is this my last pill ever?’ UCSF therapy offers patients a hint at a cure for HIVSeven of 10 volunteers kept HIV at bay for months after stopping meds, a rare result scientists call a major step toward a functional cure. 274
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/202510/ This was a small, single-arm, proof-of-concept study. The findings need to be replicated in other studies, several of which are enrolling now. Deeper investigations into the nature of the responding CD8+ T cells and the role of the bNAbs in potentiating host immune responses are ongoing. 122
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20259/ We think this robust expansion of CD8+ T cells in response to HIV rebound is meaningful: rare individuals who spontaneously control HIV also have CD8+ T cells with high proliferative capacity, and robust CD8+ T cell proliferation is correlated with better outcomes after cancer immunotherapy. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20258/ Just as the immune system encountered the emerging virus, controllers more robustly expanded a sub-population of activated CD8+ T cells with a progenitor/stem-like phenotype (TCF-1+PD-1+) as well as sub-populations with a cytotoxic effector phenotype (T-bet+Granzyme B+). 131
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20257/ @demisandel.bsky.social (1st PhD student in my lab!) made the key observation: early in rebound, before viral loads diverged, participants who went on to control HIV to low levels had a larger expansion of activated, cycling CD8+ T cells in the blood compared to those who did not control rebound. 132
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20256/ Measurements of the viral reservoir - HIV DNA and RNA levels in peripheral blood CD4+ T cells - were relatively low in these participants (likely related to having started ART early) and they were unaffected by the immunotherapies. So why did we observe better control of HIV off of ART? 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20255/ Notably, six participants had unusual HIV rebound patterns. The slope of rebound (i.e., the rate of the viral load increase day-after-day) was quite slow and then they sustained low viral loads for several months. One participant did not rebound at all despite being off ART for over 18 months. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20254/ After bNAbs waned and/or if the virus lost bNAb susceptibility (modeled by Amelia Deitchman), 3 participants rebounded as expected: they had a rapid increase in HIV levels in the blood to relatively high viral loads. They all re-started ART pretty quickly after the virus showed up in the blood. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20253/ The single-arm, proof-of-concept study was based on a regimen that showed promising results in non-human primate models. Most of the 10 participants had started ART within 6 months of acquiring HIV. With no immunotherapy, we expected 1-2 might experience partial control of HIV after stopping ART. 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20252/ The regimen included: During ART: therapeutic vaccination (to enhance HIV-specific T cell responses vs conserved elements of HIV), then 2 broadly neutralizing antibodies (bNAbs) + an immune activator (TLR9a; to reduce the reservoir) When stopping ART: bNAbs (to potentiate host immune responses) 121
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 02/12/20251/ We are making progress towards finding a cure for HIV. In a trial @UCSF led by Steve Deeks and @michaelpelusomd.bsky.social, 7/10 participants who received a combination of immunotherapies achieved partial control of HIV after stopping antiretroviral therapy (ART).🧵 www.nature.com/articles/s41...nature.comCorrelates of HIV-1 control after combination immunotherapy - NatureNature - Correlates of HIV-1 control after combination immunotherapy 1289
Reposted by Demi SandelamfAR @amfarofficial.bsky.social · 01/12/2025amfAR-funded study by UCSF shows promise for post-treatment HIV control. Most participants show a strong immune response during early viral rebound, demonstrating that, if properly assisted, the immune system can keep HIV in check w/out continued therapy. www.washingtonpost.com/science/2025...washingtonpost.comSmall study shows a promising path toward HIV cureAntiretroviral drugs that prevent HIV and keep it in check have been transformative, but a cure has been a long sought goal. 031
Reposted by Demi SandelStand Up for Science! @standupforscience.net · 16/06/2025🚨HUGE SCIENCE WIN ALERT🚨 NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science! #StandUpforScience #SummerFightforScience 3559140
Reposted by Demi SandelScott Delaney @scott-delaney.bsky.social · 16/06/2025THIS IS IT! THIS IS HUGE!! PLAINTIFF'S WIN!! Judge Young rules that the NIH grant terminations at issue in these cases are illegal and therefore vacated. BOOM! 121574366
Reposted by Demi SandelDon Moynihan @donmoyn.bsky.social · 09/05/2025New from me: Everything feels overwhelming. But here is a tangible thing you can do: write a comment to oppose Trump's plan to convert 50,000 career civil servants into political appointees. Deadline is May 23. Please share! donmoynihan.substack.com/p/here-is-a-...donmoynihan.substack.comHere is a specific thing you can do to fight Trump's politicization of public servicesPlus: what I wrote in Science about the revised Schedule F 5514871050
Reposted by Demi SandelScience Magazine @science.org · 01/05/2025With a torrent of executive orders, President Donald Trump has turned U.S. science upside down in his first 100 days, and the onslaught isn’t likely to end soon. scim.ag/3Yti8Xgscim.agAfter 100 days of upheaval, what’s next for U.S. science?Fights over research spending and pending court rulings loom large 14215
Reposted by Demi SandelJeremy Berg @jeremymberg.bsky.social · 21/04/2025NIH just posted a Notice with the new Terms and Conditions... grants.nih.gov/grants/guide...grants.nih.govNOT-OD-25-090: Notice of Civil Rights Term and Condition of AwardNIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Civil Rights Term and Condition of Award NOT-OD-25-090. NIH 16135124
Reposted by Demi SandelScott Delaney @scott-delaney.bsky.social · 21/04/2025🧪 Our Terminated NSF Grant Tracker is live 🧪 🔴 114 NSF grants listed so far 🔴 Cancelled grants focused on → Training scientists → Misinformation → AI → Climate change Credit to @noamross.net for all the work to build this & to all PIs who submitted their info. Link: airtable.com/appGKlSVeXni... 5187133
Reposted by Demi SandelJohn Green @johngreensbluesky.bsky.social · 22/04/2025Absolutely devastating reporting from Hana Kiros on what "life-saving aid" has come to mean and not mean, and the many children dying as a result. www.theatlantic.com/health/archi...theatlantic.com‘In Three Months, Half of Them Will Be Dead’Elon Musk promised to preserve lifesaving aid to foreign children. Then the Trump administration quietly canceled it. 12797166
Reposted by Demi SandelAnirvan Chatterjee @chatterjee.net · 12/04/2025“The Trump administration is now tearing down that legacy. It has cut funding and programs for HIV research, treatment, and prevention so deeply that “we’re watching the field burn to the ground,” Rebecca Fielding-Miller, a behavioral scientist and an HIV researcher at UC San Diego, told me.”theatlantic.comTrump’s Revenge on Public HealthThe attacks on HIV research are just the beginning of unraveling decades of progress. 0139
Reposted by Demi SandelRyan Hernandez @rdhernand.bsky.social · 02/04/2025I have learned that the directors of ALL: PREP, IMSD, and IRACDA programs across the country have received similar cancelation notices. This follows previous cancellations of MARC and URISE programs. This further dismantles the mechanisms that enable scientific training opportunities for SO MANY. 915396
Reposted by Demi SandelScott Delaney @scott-delaney.bsky.social · 04/04/2025An important point getting overlooked: When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on *what* the grant studies. They're cancelling them based on *who* is doing the research. And that disallowed "who" is anyone not white. 782830922
Reposted by Demi SandelDavid Malakoff @davidmalakoff.bsky.social · 01/04/2025NEW: “It’s chaos—absolute chaos,” said one NIH senior scientist watching the firings unfold. Some senior NIH officials given hours to decide if the agreed to be reassigned to jobs in Alaska, Oklahoma, and other states. | AAAS www.science.org/content/arti...science.orgTrump administration purges U.S. health agency leadersReassignment letters come as reduction in force begins 13425
Reposted by Demi SandelUnion of Concerned Scientists @ucs.org · 31/03/2025Open letter from nearly 2000 NAS member scientists: "We see real danger in this moment. We hold diverse political beliefs, but we are united (...) in wanting to protect independent scientific inquiry. We are sending this SOS to sound a warning: the nation’s scientific enterprise is being decimated."docs.google.comPublic Statement on Supporting Science for the Benefit of All CitizensTO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr... 281048475
Reposted by Demi SandelJohn Green @johngreensbluesky.bsky.social · 28/03/2025We fell down the staircase: A conversation with @stephanienolen.bsky.social about tuberculosis and making our future more perilous. www.nytimes.com/2025/03/27/h...nytimes.comFor John Green, It’s Tuberculosis All the Way DownThe best-selling author “got a little emotional” while talking with The Times about tuberculosis. Listen to the conversation. 754535
Reposted by Demi SandelEric Topol @erictopol.bsky.social · 31/03/2025On a letter I signed www.nytimes.com/2025/03/31/s...nytimes.comTrump Administration Has Begun a War on Science, Researchers Say (Gift Article)Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts. 4322103
Reposted by Demi SandelRachael Sirianni, PhD @docsirianni.bsky.social · 27/03/2025They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul... 16371245
Reposted by Demi SandelJoshua Weitz @joshuasweitz.bsky.social · 28/03/2025Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵 19664613511
Reposted by Demi SandelWHO @who.int · 27/03/2025A decline in funding for the HIV response could result in millions of preventable new infections and deaths, with up to 120,000 of these deaths affecting children. International cooperation is essential to sustain the advances we’ve made in HIV prevention, testing, and treatment. bit.ly/43uTfxA 25969365
Reposted by Demi SandelScience Magazine @science.org · 27/03/2025The NIH plans to resume posting notices of new solicitations for grant proposals. But there’s a catch: The HHS and DOGE will review each draft notice to ensure the research that will be funded aligns with the priorities of President Trump’s administration, Science has learned. scim.ag/3DJsafLscim.agTrump officials will screen NIH funding opportunitiesStaff at biomedical agency worry about political interference in setting priorities 58260
Reposted by Demi SandelKathleen Bachynski @bachynski.bsky.social · 26/03/2025“The cancellations stunned scientists who had depended on the government’s support. “The idea that we don’t need further research to learn how to treat health problems caused by coronaviruses and prevent future pandemics because ‘Covid-19 is over’ is absurd,” said Pamela Bjorkman”nytimes.comH.H.S. Scraps Studies of Vaccines and Treatments for Future PandemicsFederal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens. 34127
Reposted by Demi SandelJulie Zebrak @juliezebrak.bsky.social · 25/03/2025“Until I left last week, I led the CDC’s public health messaging. Now we need something to replace it.” When the government becomes a health misinformation superspreader www.washingtonpost.com/opinions/202...washingtonpost.comOpinion | When the government becomes a health misinformation superspreaderUntil I left last week, I led the CDC’s public health messaging. Now we need something to replace it. 34815
Reposted by Demi SandelEric Topol @erictopol.bsky.social · 25/03/2025In <24 hours, Covid funding is DOGEd across HHS, CDC, NIH as if it and Long Covid didn't exist and there is no worry for future pandemics www.science.org/content/arti... www.nbcnews.com/health/healt... www.science.org/content/arti... 18932131364
Reposted by Demi SandelWaggoner Lab @labwaggoner.bsky.social · 19/03/2025Combination immunotherapy induces post-intervention control of HIV www.researchsquare.com/article/rs-6... 073
Reposted by Demi SandelRachel Rutishauser @rrutishauser.bsky.social · 20/03/2025Excited to share this preprint: In trial led by @michaelpelusomd.bsky.social and Steve Deeks, combination immunotherapy=>high rate of HIV control (low VL) after ART pause. @demisandel.bsky.social in our lab found control associated with robust CD8+ T cell proliferation early in response to rebound. 0125