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Demi Sandel

@demisandel.bsky.social
62 followers 138 following 0 posts

5th year PhD candidate in Biomedical Sciences @ UCSF in the Rutishauser and Spitzer labs | formerly Jacks lab @ MIT and Newman lab @ LA Tech | Studying CD8+ T cell responses in HIV and cancer

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Reposted by Demi Sandel
Rachel Rutishauser @rrutishauser.bsky.social · 04/12/2025
8/ POZ magazine: www.poz.com/article/comb...
poz.com
Combination Immunotherapy May Help T Cells Fight HIV
An HIV vaccine plus broadly neutralizing antibodies and an immune-stimulating drug helped control HIV after stopping antiretrovirals.
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Rachel Rutishauser @rrutishauser.bsky.social · 03/12/2025
7/ San Francisco Examiner: www.sfexaminer.com/news/public-...
sfexaminer.com
HIV treatment in small UCSF study shows promise
Researchers tout effectiveness of method that wouldn’t require lifetime of medication
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
6/ Nature News and Views: www.nature.com/articles/d41...
nature.com
Antibodies and T cells join forces for sustained HIV remission
Two studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a person stops taking antiviral pills.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
5/ The Seattle Times: www.seattletimes.com/seattle-news...
seattletimes.com
Path to HIV cure includes Seattle scientists
Two new studies provide insights into a possible cure for HIV, and feature the work of researchers from the UW and Fred Hutchinson Cancer Center.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
4/ UCSF: www.ucsf.edu/news/2025/12...
ucsf.edu
Long-Term HIV Control: Could this Combination Therapy Be the Key?
UCSF researchers have made strides toward an HIV cure, showing experimental immunotherapy can help control the virus without long-term antiretroviral therapy (ART). In a small study, 7 of 10 participa...
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
3/ Science: www.science.org/content/arti...
science.org
How some treatments can lead to a ‘functional cure’ for HIV
Specific class of immune cells help keep virus at bay for months or years—even in the absence of drugs
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
2/ The Washington Post (gift link): www.washingtonpost.com/science/2025...
washingtonpost.com
Small study shows a promising path toward HIV cure
Antiretroviral drugs that prevent HIV and keep it in check have been transformative, but a cure has been a long-sought goal.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
Thoughtful coverage of our study from various outlets. 🧵 1/ The SF Chonicle: www.sfchronicle.com/health/artic...
sfchronicle.com
‘Is this my last pill ever?’ UCSF therapy offers patients a hint at a cure for HIV
Seven of 10 volunteers kept HIV at bay for months after stopping meds, a rare result scientists call a major step toward a functional cure.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
10/ This was a small, single-arm, proof-of-concept study. The findings need to be replicated in other studies, several of which are enrolling now. Deeper investigations into the nature of the responding CD8+ T cells and the role of the bNAbs in potentiating host immune responses are ongoing.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
9/ We think this robust expansion of CD8+ T cells in response to HIV rebound is meaningful: rare individuals who spontaneously control HIV also have CD8+ T cells with high proliferative capacity, and robust CD8+ T cell proliferation is correlated with better outcomes after cancer immunotherapy.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
8/ Just as the immune system encountered the emerging virus, controllers more robustly expanded a sub-population of activated CD8+ T cells with a progenitor/stem-like phenotype (TCF-1+PD-1+) as well as sub-populations with a cytotoxic effector phenotype (T-bet+Granzyme B+).
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
7/ @demisandel.bsky.social (1st PhD student in my lab!) made the key observation: early in rebound, before viral loads diverged, participants who went on to control HIV to low levels had a larger expansion of activated, cycling CD8+ T cells in the blood compared to those who did not control rebound.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
6/ Measurements of the viral reservoir - HIV DNA and RNA levels in peripheral blood CD4+ T cells - were relatively low in these participants (likely related to having started ART early) and they were unaffected by the immunotherapies. So why did we observe better control of HIV off of ART?
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
5/ Notably, six participants had unusual HIV rebound patterns. The slope of rebound (i.e., the rate of the viral load increase day-after-day) was quite slow and then they sustained low viral loads for several months. One participant did not rebound at all despite being off ART for over 18 months.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
4/ After bNAbs waned and/or if the virus lost bNAb susceptibility (modeled by Amelia Deitchman), 3 participants rebounded as expected: they had a rapid increase in HIV levels in the blood to relatively high viral loads. They all re-started ART pretty quickly after the virus showed up in the blood.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
3/ The single-arm, proof-of-concept study was based on a regimen that showed promising results in non-human primate models. Most of the 10 participants had started ART within 6 months of acquiring HIV. With no immunotherapy, we expected 1-2 might experience partial control of HIV after stopping ART.
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
2/ The regimen included: During ART: therapeutic vaccination (to enhance HIV-specific T cell responses vs conserved elements of HIV), then 2 broadly neutralizing antibodies (bNAbs) + an immune activator (TLR9a; to reduce the reservoir) When stopping ART: bNAbs (to potentiate host immune responses)
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Rachel Rutishauser @rrutishauser.bsky.social · 02/12/2025
1/ We are making progress towards finding a cure for HIV. In a trial @UCSF led by Steve Deeks and @michaelpelusomd.bsky.social, 7/10 participants who received a combination of immunotherapies achieved partial control of HIV after stopping antiretroviral therapy (ART).🧵 www.nature.com/articles/s41...
nature.com
Correlates of HIV-1 control after combination immunotherapy - Nature
Nature - Correlates of HIV-1 control after combination immunotherapy
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amfAR @amfarofficial.bsky.social · 01/12/2025
amfAR-funded study by UCSF shows promise for post-treatment HIV control. Most participants show a strong immune response during early viral rebound, demonstrating that, if properly assisted, the immune system can keep HIV in check w/out continued therapy. www.washingtonpost.com/science/2025...
washingtonpost.com
Small study shows a promising path toward HIV cure
Antiretroviral drugs that prevent HIV and keep it in check have been transformative, but a cure has been a long sought goal.
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Stand Up for Science! @standupforscience.net · 16/06/2025
🚨HUGE SCIENCE WIN ALERT🚨 NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science! #StandUpforScience #SummerFightforScience
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Scott Delaney @scott-delaney.bsky.social · 16/06/2025
THIS IS IT! THIS IS HUGE!! PLAINTIFF'S WIN!! Judge Young rules that the NIH grant terminations at issue in these cases are illegal and therefore vacated. BOOM!
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Don Moynihan @donmoyn.bsky.social · 09/05/2025
New from me: Everything feels overwhelming. But here is a tangible thing you can do: write a comment to oppose Trump's plan to convert 50,000 career civil servants into political appointees. Deadline is May 23. Please share! donmoynihan.substack.com/p/here-is-a-...
donmoynihan.substack.com
Here is a specific thing you can do to fight Trump's politicization of public services
Plus: what I wrote in Science about the revised Schedule F
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Science Magazine @science.org · 01/05/2025
With a torrent of executive orders, President Donald Trump has turned U.S. science upside down in his first 100 days, and the onslaught isn’t likely to end soon. scim.ag/3Yti8Xg
scim.ag
After 100 days of upheaval, what’s next for U.S. science?
Fights over research spending and pending court rulings loom large
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Jeremy Berg @jeremymberg.bsky.social · 21/04/2025
NIH just posted a Notice with the new Terms and Conditions... grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-090: Notice of Civil Rights Term and Condition of Award
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Civil Rights Term and Condition of Award NOT-OD-25-090. NIH
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Scott Delaney @scott-delaney.bsky.social · 21/04/2025
🧪 Our Terminated NSF Grant Tracker is live 🧪 🔴 114 NSF grants listed so far 🔴 Cancelled grants focused on → Training scientists → Misinformation → AI → Climate change Credit to @noamross.net for all the work to build this & to all PIs who submitted their info. Link: airtable.com/appGKlSVeXni...
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John Green @johngreensbluesky.bsky.social · 22/04/2025
Absolutely devastating reporting from Hana Kiros on what "life-saving aid" has come to mean and not mean, and the many children dying as a result. www.theatlantic.com/health/archi...
theatlantic.com
‘In Three Months, Half of Them Will Be Dead’
Elon Musk promised to preserve lifesaving aid to foreign children. Then the Trump administration quietly canceled it.
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Anirvan Chatterjee @chatterjee.net · 12/04/2025
“The Trump administration is now tearing down that legacy. It has cut funding and programs for HIV research, treatment, and prevention so deeply that “we’re watching the field burn to the ground,” Rebecca Fielding-Miller, a behavioral scientist and an HIV researcher at UC San Diego, told me.”
theatlantic.com
Trump’s Revenge on Public Health
The attacks on HIV research are just the beginning of unraveling decades of progress.
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Ryan Hernandez @rdhernand.bsky.social · 02/04/2025
I have learned that the directors of ALL: PREP, IMSD, and IRACDA programs across the country have received similar cancelation notices. This follows previous cancellations of MARC and URISE programs. This further dismantles the mechanisms that enable scientific training opportunities for SO MANY.
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Scott Delaney @scott-delaney.bsky.social · 04/04/2025
An important point getting overlooked: When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on *what* the grant studies. They're cancelling them based on *who* is doing the research. And that disallowed "who" is anyone not white.
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David Malakoff @davidmalakoff.bsky.social · 01/04/2025
NEW: “It’s chaos—absolute chaos,” said one NIH senior scientist watching the firings unfold. Some senior NIH officials given hours to decide if the agreed to be reassigned to jobs in Alaska, Oklahoma, and other states. | AAAS www.science.org/content/arti...
science.org
Trump administration purges U.S. health agency leaders
Reassignment letters come as reduction in force begins
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Union of Concerned Scientists @ucs.org · 31/03/2025
Open letter from nearly 2000 NAS member scientists: "We see real danger in this moment. We hold diverse political beliefs, but we are united (...) in wanting to protect independent scientific inquiry. We are sending this SOS to sound a warning: the nation’s scientific enterprise is being decimated."
docs.google.com
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
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John Green @johngreensbluesky.bsky.social · 28/03/2025
We fell down the staircase: A conversation with @stephanienolen.bsky.social about tuberculosis and making our future more perilous. www.nytimes.com/2025/03/27/h...
nytimes.com
For John Green, It’s Tuberculosis All the Way Down
The best-selling author “got a little emotional” while talking with The Times about tuberculosis. Listen to the conversation.
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Eric Topol @erictopol.bsky.social · 31/03/2025
On a letter I signed www.nytimes.com/2025/03/31/s...
nytimes.com
Trump Administration Has Begun a War on Science, Researchers Say (Gift Article)
Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.
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Rachael Sirianni, PhD @docsirianni.bsky.social · 27/03/2025
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
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Joshua Weitz @joshuasweitz.bsky.social · 28/03/2025
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵
US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.
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WHO @who.int · 27/03/2025
A decline in funding for the HIV response could result in millions of preventable new infections and deaths, with up to 120,000 of these deaths affecting children. International cooperation is essential to sustain the advances we’ve made in HIV prevention, testing, and treatment. bit.ly/43uTfxA
10 million potential new HIV infections by 2030; 3 million potential more deaths, including 120,000 children, due to HIV-related causes by 2030. This could be the impact of HIV funding cuts.
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Science Magazine @science.org · 27/03/2025
The NIH plans to resume posting notices of new solicitations for grant proposals. But there’s a catch: The HHS and DOGE will review each draft notice to ensure the research that will be funded aligns with the priorities of President Trump’s administration, Science has learned. scim.ag/3DJsafL
scim.ag
Trump officials will screen NIH funding opportunities
Staff at biomedical agency worry about political interference in setting priorities
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Kathleen Bachynski @bachynski.bsky.social · 26/03/2025
“The cancellations stunned scientists who had depended on the government’s support. “The idea that we don’t need further research to learn how to treat health problems caused by coronaviruses and prevent future pandemics because ‘Covid-19 is over’ is absurd,” said Pamela Bjorkman”
nytimes.com
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
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Julie Zebrak @juliezebrak.bsky.social · 25/03/2025
“Until I left last week, I led the CDC’s public health messaging. Now we need something to replace it.” When the government becomes a health misinformation superspreader www.washingtonpost.com/opinions/202...
washingtonpost.com
Opinion | When the government becomes a health misinformation superspreader
Until I left last week, I led the CDC’s public health messaging. Now we need something to replace it.
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Eric Topol @erictopol.bsky.social · 25/03/2025
In <24 hours, Covid funding is DOGEd across HHS, CDC, NIH as if it and Long Covid didn't exist and there is no worry for future pandemics www.science.org/content/arti... www.nbcnews.com/health/healt... www.science.org/content/arti...
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Waggoner Lab @labwaggoner.bsky.social · 19/03/2025
Combination immunotherapy induces post-intervention control of HIV www.researchsquare.com/article/rs-6...
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Rachel Rutishauser @rrutishauser.bsky.social · 20/03/2025
Excited to share this preprint: In trial led by @michaelpelusomd.bsky.social and Steve Deeks, combination immunotherapy=>high rate of HIV control (low VL) after ART pause. @demisandel.bsky.social in our lab found control associated with robust CD8+ T cell proliferation early in response to rebound.
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