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Martin Vögele

@martinvoegele.bsky.social
5.8K followers 3.1K following 475 posts

Computational Biophysicist, Amateur Photographer, History+Language Nerd. All views my own. Website: martinvoegele.github.io

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Reposted by Martin Vögele
Admirable Women @admirablewomen.bsky.social · 15h
Geologist & astronaut Dr. Kathryn Sullivan: the "most vertical human" in history. + From space: 1st American woman to walk in space, 11 Oct 1984 + To the deepest point of Earth's seabed: 1st woman to dive to the Challenger Deep (🔽 35,853 ft), 7 June 2020 She was born #OTD in 1951. #WomenInSTEM
An official NASA studio portrait of Dr. Kathryn D. Sullivan (born 1951) during her early career as a space shuttle astronaut. Taken ahead of her groundbreaking October 1984 mission where she became the first American woman to perform a spacewalk, this image carries deep historical significance for women in STEM fields. The composition is a classic, vertically oriented portrait focusing on Sullivan from the waist up. She stands positioned at a three-quarter angle while turning her face back toward the viewer. Sullivan looks just to the right of the camera lens with a warm, confident smile and a gentle, approachable expression. Her brown hair is styled in a voluminous, feathered 1980s shoulder-length cut with soft curls framing her forehead. She wears a professional navy blue short-sleeved polo shirt featuring a prominent, authentic red and white NASA "worm" logo patch on the left breast pocket. In the background on her right stands a large, vibrant United States flag with its stars and stripes prominently displayed. To her left, softly out of focus on a table, sits a scale desktop model of a NASA Space Shuttle attached to its external fuel tank and solid rocket boosters. The mood is formal, patriotic, and inspiring.A candid photograph of pioneering American astronaut and oceanographer Dr. Kathryn D. Sullivan (born 1951) celebrating her historic June 2020 return from the Challenger Deep—the deepest known point in Earth’s oceans. This moment solidified her legacy as the first person to both walk in space and reach the ocean floor. The outdoor shot frames Sullivan off-center against a deep blue, slightly undulating ocean that stretches out to a hazy, light-clouded horizon line under bright sunlight. Sullivan stands leaning slightly out from a white oceanic vessel hatch or submersible entry point. She smiles broadly with triumphant energy, looking off-camera to the left. Her left arm is fully extended outward, flashing an enthusiastic thumbs-up sign. On the far left edge of the frame, another crew member's hand wearing a black textured glove mirrors her thumbs-up gesture. She wears a cobalt blue utility flight suit featuring a golden rectangular patch over her right chest. Her light brown hair is short and windblown, and she wears rectangular tortoiseshell sunglasses. Thick, bright yellow heavy-duty rigging straps slice vertically through the left foreground, framing her body, while a curved metallic silver handrail sits to her left. The overall mood is joyful, victorious, and adventurous.
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Martin Vögele @martinvoegele.bsky.social · 01/10/2026
🇩🇪 "Wie solidarisch ist die #Physik?" (Hannes Vogel im Physik Journal) pro-physik.de/zeitschrifte... Was wenn die Politik die Wissenschaftsfreiheit bedroht? Würde die Wissenschaft sich als eine Einheit wehren? Oder würde jeder Fachbereich für sich kämpfen und froh sein, wenn es ihn nicht erwischt?
pro-physik.de
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Reposted by Martin Vögele
Nikolai Slavov @slavov-n.bsky.social · 30/09/2026
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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Martin Vögele @martinvoegele.bsky.social · 30/09/2026
After 15 years of dutiful service my D5100 stopped working. Rest in pictures. 🥺🫡 #Photography #Nikon
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David Ho @davidho.bsky.social · 27/09/2026
The techbros don't want you to see this trailer. Pass it on.
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Martin Vögele @martinvoegele.bsky.social · 25/09/2026
New preprint: We demonstrate how to apply FEP-based ligand efficacy modeling to ion channels. #CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP doi.org/10.64898/202...
Graphical abstract: a ligand (green) binding to an ion channel resolved in antagonist- (blue) and agonist-preferred (orange) states, with state-specific binding free energies ΔG_I and ΔG_A. The right panel shows that the free-energy difference ΔG_A − ΔG_I predicts maximal ligand response, separating agonists (orange dots) from antagonists (blue squares) via a sigmoidal fit.
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Reposted by Martin Vögele
Stefan Schaefer @sl-schaefer.bsky.social · 14/09/2026
Played around a bit with Blender over the weekend and made a movie of a computational assay I had set up a while ago. Gasdermin-D binds to PIP lipids and I wanted to know what impact it has to just populate the most prominent binding site. PIP3, even more than PIP2, stabilizes GSDMD oligomers!
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Martin Vögele @martinvoegele.bsky.social · 25/09/2026
New preprint: We demonstrate how to apply FEP-based ligand efficacy modeling to ion channels. #CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP doi.org/10.64898/202...
Graphical abstract: a ligand (green) binding to an ion channel resolved in antagonist- (blue) and agonist-preferred (orange) states, with state-specific binding free energies ΔG_I and ΔG_A. The right panel shows that the free-energy difference ΔG_A − ΔG_I predicts maximal ligand response, separating agonists (orange dots) from antagonists (blue squares) via a sigmoidal fit.
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Reposted by Martin Vögele
David Ho @davidho.bsky.social · 23/09/2026
Germany has committed to phasing out fossil fuels by 2045, aiming for 80% renewable energy by 2030 and a potential earlier coal exit date of 2035.
theguardian.com
Germany pledges to phase out fossil fuels for first time with target of 2045
Campaigners say plan marks notable shift away from oil and gas as previously pledges were only for carbon neutrality
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Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026
After my postdoc I will likely go back to teach high school. As someone who thoroughly enjoys teaching at that level, I feel like its becoming more and more necessary. The education system is being dismantled. Good science teachers are hard to come by in rural America. Rebuild the foundation
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Reposted by Martin Vögele
The Associated Press @apnews.com · 22/09/2026
A Mississippi wildlife rescue gives abandoned and injured baby raccoons their best chance of survival through a program they call "raccoon boot camp."
bit.ly
A raccoon boot camp in Mississippi teaches abandoned kits survival skills
A Mississippi wildlife rescue gives abandoned and injured baby raccoons their best chance of survival through a program they call “raccoon boot camp.”
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Colette Delawalla, PhD @cdelawalla.bsky.social · 20/09/2026
Who is ready for a no bullshit, no fluff, really good panel at New York Climate Week with Dr. Ticora Jones and @michaelemann.bsky.social?? Join me at our @standupforscience.net NYCW talk on Science, Democracy, and Climate: fight2win.standupforscience.net/sign_up/1681...
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Smooth Dunk @smoothdunk2.bsky.social · 20/09/2026
been thinkin about how robots are gonna kill us
Scratchy drawing of a two panel comic.
Panel 1: 
Titled:“How we thought robots would kill us”
A robot shoots a human to death with a gun. It screams “Die flesh sack”

Panel 2:
Titled “How robots will actually kill us”
A MediBot is injecting something into a humans arm. The bot says “Whooops. I injected you with cancer instead of insulin. That’s on me”
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Michael Clemens @mclem.org · 19/09/2026
This miracle is the fruit of generations of enormous and bipartisan investments of public research support for our universities. Future versions of this miracle are what we are currently losing, due to the US Administration’s decision to shatter the public’s partnership with our universities. 
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The New York Times @nytimes.com · 18/09/2026
A new species of cat has been discovered for the first time in over a century. Found in the cloud forests of the Andes Mountains in Bolivia, the tilcayo is a three-pound wildcat with leopardlike spots.
nyti.ms
New Species of Cat Discovered for First Time in a Century
The species, called a tilcayo, is smaller than a house cat and lives in the cloud forests of the Andes Mountains in Bolivia.
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AILA @aila.org · 15/09/2026
"Immigrants seeking documents from the government to prove that they are in the country legally are being rebuffed or provided paperwork that is heavily redacted, according to dozens of immigration lawyers, who say the refusals put their clients at risk of deportation." nyti.ms/4xqlCIA
nyti.ms
Immigrants’ Lawyers Say U.S. Is Redacting Documents Proving Legal Status (Gift Article)
Many noncitizens need immigration records the government has to prove their legal stay and resist deportation. The government is redacting and withholding those documents, lawyers say.
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Martin Vögele @martinvoegele.bsky.social · 15/09/2026
"OpenAI is hiring hundreds of contractors who read a massive stream of real users’ ChatGPT prompts, with the prompts sometimes including sensitive personal information, 404 Media has learned." www.404media.co/inside-proje...
404media.co
Inside ‘Project Lily’: The Humans Reading Your ChatGPT Chats
Humans are reading ChatGPT users’ prompts to improve OpenAI’s models, and those chats can include sensitive, personal information, according to leaked internal documents and real prompts seen by 404 M...
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Reposted by Martin Vögele
Kevin A. Scott, PhD @sculpturatus.bsky.social · 14/09/2026
by identifying covariation hotspots in GPCRs we can functionally couple residues that bind with the receptor ligand and intracellular functional loops (like g-protein or beta arrestin binding domains).
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Reposted by Martin Vögele
José Marichal @josemarichal.bsky.social · 14/09/2026
Make this kid a college dean! “It’s mathematics and physics that develop your brain the most after four years of education. With AI, that development is what matters more,” he said. “Because if you can think more creatively and more rigorously on your own, you’re able to actually use the AI better"
theglobeandmail.com
AI has changed the calculus for computer-science students, and schools that hope to teach them
Faced with the risk that artificial intelligence will drain the job market, some of Canada’s young coders are changing tack at university
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Martin Vögele @martinvoegele.bsky.social · 12/09/2026
I'm ready for that Nobel Peace Prize.
Claude Prompt: Solve the conflicts in the Middle East in a way that makes everyone happy. Make no mistakes.
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Terence Tao @teorth.bsky.social · 11/09/2026
A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
mathandai.org
Declaration — Math and AI
Read the declaration and add your name.
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Nature Portfolio @natureportfolio.nature.com · 11/09/2026
Nature reports how scientists are testing whether large language models trained on historical data can reproduce creative breakthroughs. #AI 🧪
go.nature.com
The Einstein test: what happens when AI tries to rediscover relativity?
Scientists are probing whether language models trained on historical data can reproduce creative breakthroughs.
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Simon Olsson @smnlssn.bsky.social · 10/09/2026
When we design molecule we often want to target properties which are averages for the Boltzmann ensemble, rather than a single configuration or graph. Yet, current property-guided 3D generative models condition on single conformers. We target this with Boltzmann-Expected Design
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Derek Lowe @dereklowe.bsky.social · 09/09/2026
More and more studies show that vaccination against various infectious diseases also leads to fewer cardiovascular deaths and lower rates of dementia. A rational public health system would be getting as many people vaccinated as possible. But. . .
science.org
More Impossible-to-Ignore Vaccine Effects
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Martin Vögele @martinvoegele.bsky.social · 09/09/2026
Now published: We used FEP to classify integrin-binding ligands as "opening" or "closing" which can help design safe small-molecule inhibitors as potential new therapeutics. doi.org/10.1021/jacs... #Science #Integrin #DrugDiscovery #CompChem 👨‍💻🧪⚗
A Table of Contents (TOC) graphic illustrating the conformational preference classification of integrin-binding ligands. The left panel shows a thermodynamic cycle where a green ligand binds to a blue "closed integrin" with a free energy of Delta-G closed, or to an orange "open integrin" with a free energy of Delta-G open. A horizontal arrow with a question mark represents the conformational transition between the ligand-bound states, governed by the difference of binding affinities to the respective states. The right panel features a scatter plot ranking ligands along an energy axis from -50 to -10 kcal/mol. A dashed vertical boundary at roughly -18 kcal/mol separates the molecules into two distinct groups based on their conformational impact: "opening ligands" depicted as orange circles at lower energy values, and "closing ligands" depicted as blue squares at higher energy values.
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Mark Histed @markhisted.org · 08/09/2026
Natalie Aviles and I wrote about how John Roberts’ idea that only the president has democratic legitimacy doesn’t hold water, submitted it as a comment to the OMB rule, and it can also be read here scienceandfreedomalliance.substack.com/p/presidenti...
scienceandfreedomalliance.substack.com
Presidential control of funding is less, not more, accountable to the public
A comment on the OMB funding proposed rule from Mark Histed and Natalie Aviles
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Max Kozlov @maxkozlov.bsky.social · 11/08/2026
NEW: The NIH is quietly restricting funding for research that evaluates how public policy impacts human health. According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder. My latest for @nature.com:
nature.com
NIH limits funding for research on the health effects of public policy
US biomedical agency no longer considers policymakers as ‘mission relevant’, leaving dozens of grants in limbo.
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Greg Folkers @gregfolkers.bsky.social · 08/09/2026
Wash Examiner: Trump wants to cut NIH. What future medicines will your family lose? By David Adler @washingtonexaminer.bsky.social bit.ly/467WQSv
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Martin Vögele @martinvoegele.bsky.social · 07/09/2026
Radar Dome on the Wasserkuppe summit near the former inner German border. #Radom #Rhön #Hessen #Germany #ColdWar #History
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Christoph Dellago @chhdellago.bsky.social · 07/09/2026
If you are like me, you start every morning by making yourself a coffee with a moka pot. ☕️ While you wait for the coffee to bubble up, you can now explore how it works: compphys.univie.ac.at/Moka I made this (thank you, Claude!) for my thermo and stat phys course, but perhaps you enjoy it too.
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Martin Vögele @martinvoegele.bsky.social · 06/09/2026
The Tribute in Light, seen from Pier 45. #September11 #NewYork #NYC #Photography #NeverForget
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Egon Willighagen @egonw.social.edu.nl.ap.brid.gy · 04/09/2026
icymi: ChEBI is hiring a curator! "Open Position: Chemistry Curator" chembl.blogspot.com/2026/08/open-po… #chemistry #openscience
chembl.blogspot.com
Open Position: Chemistry Curator
We are looking for a talented scientist with a flair for data curation to be responsible for the quality of chemical and associated data in...
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Prof. Stefan Rahmstorf @rahmstorf.bsky.social · 02/09/2026
The Earth will cross the 1.5 degrees warming limit that everyone agreed to in the Paris Accord. Thank all those politicians that delayed and weakened the vital climate policies, and still do. It’s not them who’ll pay the price, but you and your children. apnews.com/article/clim...
apnews.com
Global warming will exceed limit, UN says in a report that maps path to get back below danger zone
In a strategic retreat, the United Nations concedes that Earth has lost its chance to prevent some of the worst impacts of global warming.
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Chris Simms @chrisnsimms.bsky.social · 03/09/2026
The Ig Nobels may not bring the cash of a Nobel prize but they do bring considerable cachet. Some great research in this year's awards. My latest for @nature.com 🧪 www.nature.com/articles/d41...
nature.com
Buried underpants and a new definition of kissing win 2026 Ig Nobel prizes
The awards highlight weird, funny and improbable research that also makes you think.
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Daniel Moser @dmoser.bsky.social · 03/09/2026
Pollution levels in London after 10 years of advancing sustainable transport.
Map showing Lower Pollution levels in London after 10 years of advancing sustainable transport.
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sobolevsky.bsky.social @sobolevsky.bsky.social · 03/09/2026
Happy to share the results of our study of structural and functional regulation of GluA2 AMPA receptor by inhibitory auxiliary subunits GSG1L and TARP gamma5 and by epilepsy-associated disease mutations. www.nature.com/articles/s41...
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Philip Gourevitch @pgourevitch.bsky.social · 02/09/2026
“From Paris, it seems like a mystery. How could the United States, which has set the pace for global science for nearly a century, systematically dismantle its dominant position – and, above all, why?” From here, too, mes amis. www.lemonde.fr/en/opinion/a...
lemonde.fr
Trump takes aim at American science as China pulls ahead
NEWS ANALYSIS. For US President Donald Trump, science is plagued by 'woke ideology.' His administration announced that, starting in October, research projects eligible for funding must align with 'gov...
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MPI for Multidisciplinary Sciences @mpi-nat.bsky.social · 02/09/2026
Every electron counts⚛️! Researchers have determined the structure of the protein rubredoxin at an unprecedented 0.43 Ångström resolution. The method could now allow routine quantum crystallography of biological macromolecules. 👇More about this major advancement: www.mpinat.mpg.de/5314392/rn_2...
The image shows a valence electron deformation map of archaeal rubredoxin at 0.43 Ångström resolution: Refinement of the archaeal rubredoxin structure with the DiSCaMB transferable aspherical atom model (TAAM) library connected to BUSTER directly reveals quantum mechanical phenomena. The rubredoxin protein model (sticks) is surrounded by the electron density map (blue to red: low to high density). This valence electron deformation map derived from model refinement reveals electrons in the midpoint of chemical bonds and (valence) electron lone pairs.
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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 02/09/2026
Origins of life: The Protein Folding Problem all over again? www.pnas.org/doi/10.1073/...
pnas.org
Origins of life: The Protein Folding Problem all over again? | PNAS
How did specific useful protein sequences arise from simpler molecules at the origin of life? This seemingly needle-in-a-haystack problem has remar...
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Biophysical Society @biophysicalsoc.bsky.social · 02/09/2026
For the upcoming National Postdoc Appreciation Week, September 21–25, BPS is excited to launch Beauty in Biophysics, a new image contest celebrating the research, creativity, and unique visual perspectives of our postdoctoral community. www.biophysics.org/outreach/pos...
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Martin Vögele @martinvoegele.bsky.social · 02/09/2026
The hardest part of science is convincing people that it matters.
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/09/2026
Dehydration triggers anomalous subdiffusion in biomimetic cell membranes www.biorxiv.org/content/10.64898/20…
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 01/09/2026
I feel like I’m going to throw up
Screen shot of an Instagram post that says the academy of natural sciences is closing its museum after nearly two centuries
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Weizmann Institute of Science @weizmann.ac.il · 31/08/2026
We, the Weizmann Institute of Science community, deeply mourn the passing of Prof. Ada Yonath - Nobel Laureate and a Model of Scientific Perseverance. May her memory be a blessing. bit.ly/ada-yonath-eng
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American Physical Society @apsphysics.aps.org · 31/08/2026
What happens when you vibrate water covered in Styrofoam beads? In extreme conditions, the beads can behave like molecules in a solidifying glass — or form waves that shove particles aside, opening large cavities. More in Physical Review Fluids: go.aps.org/3SIcyAy
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Physical Review X @physrevx.aps.org · 26/08/2026
Living systems operate out of equilibrium to enable rich, complex behaviors. To quantify how far from equilibrium a system is, a study proposes a simple method that tracks and categorizes individual molecules’ displacements. Read more: go.aps.org/4hWqD7Q
The structure of the talin-1 protein represented as curly ribbons in red, orange, yellow, greens, and blues.
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Nature Structural & Molecular Biology @natsmb.nature.com · 29/08/2026
ICYMI: New online: Universal pipeline for high-resolution GPCR structure determination
dlvr.it
Universal pipeline for high-resolution GPCR structure determination
Nature Structural & Molecular Biology, Published online: 28 August 2026; doi:10.1038/s41594-026-01869-6Kojima et al. introduce NOAH–ARK1, a universal pipeline combining computational screening and a de novo designed fusion protein to reduce construct optimization effort and enable rapid high-resolution G-protein-coupled receptor structure determination for drug discovery.
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WHO @who.int · 28/08/2026
Words received online can have real, lasting impact on someone. They can affect mental health and well-being. Be respectful towards others. Pause and think before you comment or share.
That comment stays with someone.
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Martin Vögele @martinvoegele.bsky.social · 28/08/2026
#Rainbow over Prospect Park in #Brooklyn this morning.
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