In a series of private meetings, the company consulted religious scholars to help instill morality into its A.I. models — and make the case that Claude could be conscious.

A fundamental principle in molecular biology holds that ribosomes face a trade-off between translation speed and accuracy: going faster means making more errors, while maintaining high fidelity requires slowing down. This study challenges that paradigm by identifying a small molecule that increases translational accuracy in mycobacteria without affecting the rate of protein synthesis. The compound targets ribosomal protein S5 and specifically reduces errors arising from physiologically mischarged tRNAs—a quality control problem distinct from the well-studied codon-anticodon mismatches. This form of mistranslation contributes to antibiotic tolerance in tuberculosis, making it a potential therapeutic target. Our findings reveal unexpected flexibility in how ribosomes maintain translation quality and suggest that pharmacologically increasing fidelity without the fitness cost of slowed protein synthesis may be an attractive strategy for combating antibiotic-tolerant bacteria.

Ribosome hibernation helps cells survive stress by reversibly silencing translation and preserving ribosomal complexes. Although well characterized in bacteria and eukaryotes, archaeal hibernation rem...

For setting up a living dataset. Contribute to arjunrajlaboratory/mycelium development by creating an account on GitHub.

The AI-based assessment, which wasn’t explicitly described in the funding call, has raised privacy and fairness concerns

3-Phosphoinositides are essential cellular lipids regulating health and disease. Among them, phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] remains the least understood. Using a newly developed rat...

Protein synthesis declines with age across many tissues, but whether this decline actively contributes to physiological aging remains unclear. Oocytes may be particularly vulnerable because they rely ...

The opportunistic human pathogen Candida albicans depends on the unfolded protein response (UPR) for cell wall integrity, antifungal tolerance, filamentous growth, and virulence. The UPR is driven by ...

Fluorescent proteins are widely used as quantitative reporters of protein abundance in living cells. Here we show that this relationship can break down under translation inhibition: the cellular ribos...

Communications Biology - Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Many cancers associated with infection are preventable

Lung cancer is still the top cancer killer, but new developments are shifting what the future might hold for patients.

An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.

A delayed clinical trial underscores the stakes of federal research funding cuts for children with DIPG, a deadly brain tumor with few treatment options.

Kevan Shokat, PhD, a professor of Cellular and Molecular Pharmacology at UC San Francisco who discovered how to disable KRAS, a seemingly unstoppable cancer-driving protein, has won the Stephenson Glo...

Small-molecule modulators of protein synthesis are invaluable tools for dissecting the translation apparatus. This Review summarizes the mechanisms of molecules that disrupt translation in an amino ac...

The cost of the health secretary’s security grew from roughly $10 million in fiscal year 2025 to $17 million in fiscal year 2026.

America should invest in NIH medical research, not retreat from it.

The agency has lost its independence and nearly a third of its staff, as Health Secretary Robert F. Kennedy Jr. and associates have tightened control.

In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...

Mark Chen discusses how the Hugging Face cybersecurity incident prompted a pivot to safety — and giving AI models a sense of 'taste'.

Cell differentiation into distinct cell types generates functional specialization in eukaryotic organisms. Many fungal species undergo filamentous growth, where cells differentiate into elongated and ...

Biofilm formation by the fungal pathogen Candida albicans is a major source of infection. The biofilm regulator Ume6 forms complexes with partner transcription factors Efg1, Ndt80, and Upc2 to drive e...

Artificial-intelligence systems can generate hypotheses, design experiments and analyse data — but humans still need to decide what makes sense.

By Dr. Douglas R. Waverly, Professor Emeritus of Biochemistry, Yale University

The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood....

Fungi include millions of species that science doesn't know. Viv Goosens writes about how Wellcome is funding new tools to study them and projects that will turn scientific understanding into practica...

Fluorescent molecular rotors for sensing local microviscosity have become indispensable tools for better understanding the mechanisms of living systems. Current probes relay on intensity or lifetime m...

Invisibles à l’œil nu, ces micro-organismes d’une incommensurable diversité sont essentiels à nos écosystèmes. Pendant longtemps, il a été difficile de les étudier, mais l’essor de nouvelles technique...

“We should be strengthening our investment in the NIH, not dismantling it,” writes Reed Jobs.

Researchers developed a ‘virtual biotech’ made up of as many as 37,000 agents reporting to an 'chief scientist'.

Although studies of tumor invasion have mainly emphasized the evolution of genetic and epigenetic heterogeneity, cellular behaviors also depend on the physical microenvironment. Yet, the tumor microen...

Khan et al. show that mechanical forces on stalled nascent polypeptide chains (NCs) regulate the amino acid composition of carboxyl-terminal tails (CAT tails), which are a form of NC elongation that o...

A working catalogue of twelve open problems in biology — each a concrete, testable target for the field.

Three-dimensional (3D) cell morphology provides a measurable phenotype of cellular state and function, but representing it across biological systems and imaging modalities remains difficult. Existing ...

The unfolded protein response (UPR) is a cellular mechanism that maintains protein homeostasis (proteostasis) under conditions of endoplasmic reticulum (ER) stress. The dual kinase/RNase Ire1 is a con...

The use of AI in scientific authorship has moved from a speculative concern to a practical reality. Authors, reviewers, editors, publishers, and readers ar

Budding yeast cells can transition from vegetative to filamentous growth under specific environmental stimuli. Saccharomyces cerevisiae has served as a model to understand this process, which is linke...

DNA damage is an important component of the antibacterial response of phagocytes, but which DNA repair mechanisms are active in intracellular bacteria remains unclear. We developed a live-cell single-...