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Richard Marcotte

@richardmarcotte.bsky.social
596 followers 572 following 24 posts

Scientist NRC, Prof. Associe, Universite de Montreal et Affiliate member Goodman Cancer Institute McGill University. Functional genomic in cancer and immune cells, Cell engineering, gene editing, CRISPR/Cas. Views are my own

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Reposted by Richard Marcotte
Nobel Prize @nobelprize.org · 05/10/2026
BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Baptiste Lacoste @blacoste.bsky.social · 30/09/2026
🚨 Excited to share that our new paper is published today in Neuron ! We show that P2Y2 receptor activation restores cerebrovascular function and reverses behavioural impairments in mice carrying a 16p11.2 deletion. #Autism #Publication #BasicScience www.cell.com/neuron/fullt...
cell.com
Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Ouellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...
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W. Brent Derry @wbderry.bsky.social · 30/09/2026
Faculty position at the University of Toronto 👇 jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca
Assistant Professor - Systems Neurophysiology
Assistant Professor - Systems Neurophysiology
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BCCHR ResDev (DM) @resdevbcch.bsky.social · 24/09/2026
‼️ attention Canadian health researchers ‼️ #CIHR has posted the Project Grants Discussion Paper and a related *survey* cihr-irsc.gc.ca/e/54821.html Please please participate 🙏
photo of the “help shape the future of the project grant program” announcement by CIHR. TEXT is accessible in the hyperlink in this post.
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Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Le Devoir @ledevoir.com · 14/09/2026
Les scientifiques établis au Canada peinent plus que jamais à obtenir le financement nécessaire à leurs projets.
ledevoir.com
Cri du cœur des chercheurs en sciences biomédicales
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BWJones @bwjones.bsky.social · 28/08/2026
Science. In a time when science is under attack, people need to understand how our lives have been improved through scientific research. ex: PCR, a cornerstone of biomedical science is thanks to asking how bacteria reproduce at high temperatures. GLP1 drugs came from gila monster venom studies…
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Nobel Prize @nobelprize.org · 24/08/2026
We've arrived on Bluesky! We hope you will follow along as we share inspiring, motivational and exciting content about the achievements and individuals that have been awarded a Nobel Prize. Stay tuned.
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Ran Blekhman @blekhman.bsky.social · 26/07/2026
Everyone says AI will accelerate science. I don't think it will -- at least not in biology, and at least not soon. New post where I explain why, and how the productivity paradox can be resolved: blekhman.substack.com/p/why-ai-wil...
blekhman.substack.com
Why AI will not speed up science (yet)
You can see AI everywhere except in the productivity statistics
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Eric Topol @erictopol.bsky.social · 16/07/2026
This is big. The first vaccine tested to PREVENT pancreatic cancer in high-risk individuals aacrjournals.org/cancerdiscov...
aacrjournals.org
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...
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Dr. Deanna Santer @drdeannasanter.bsky.social · 14/07/2026
📢 Super excited to promote that our #Immunology department is recruiting a Tier 2 Canada Research Chair in Immunobiology of Chronic Disease!🎉🥳 Please note this is a targeted recruitment with more details via QR code. I am lucky to work here in such a collaborative environment Please share widely
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Research at Sinai Health @sinaihealth.bsky.social · 08/07/2026
Basal-like breast cancer has poor outcomes because we did not know which genes drove it. LTRI-led study out now in @nature.com reveals 81 new genes driving the disease in a major first step towards targeted therapy. 🧬 Read the story➡️ bit.ly/4vohaZY #BLBC
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John Doench @johndoench.bsky.social · 06/07/2026
New preprint from the group, comparing CRISPRko and CRISPRi via a Perturb-seq readout: www.biorxiv.org/content/10.6...
biorxiv.org
Direct comparison of CRISPR knockout and interference with Perturb-seq
CRISPR knockout (CRISPRko) and CRISPR interference (CRISPRi) are two workhorse technologies for loss-of-function studies, yet direct comparisons between the two are scant relative to their widespread ...
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Konrad Chudzik @konrad-chudzik.bsky.social · 30/06/2026
My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...
doi.org
Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus
Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno
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Stefan Pöhlmann @snpoehlm.bsky.social · 27/06/2026
The historic papers in virology series continues with another major milestone. Today, 56 years ago, two papers in Nature reported the discovery of an RNA-dependent DNA polymerase, now known as reverse transcriptase, the hallmark enzyme of retroviruses that synthesizes DNA from an RNA template.
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Andrew Pruszynski @andpru.bsky.social · 25/05/2026
I encourage everyone to show up and make your voice heard at upcoming town halls and via any other channels: cihr-irsc.gc.ca/e/45096.html • Bilingual session: Thursday, May 28 at 1:00 p.m. ET • English session: Wednesday, June 24 at 1:30 p.m. ET • French session: Thursday, June 25 at 1:30 p.m. ET
cihr-irsc.gc.ca
Webinars - CIHR
CIHR holds several webinars that allow us to share information, exchange ideas and discuss issues of importance with our stakeholders.
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Mélanie Laurin @melanielaurin.bsky.social · 22/05/2026
SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.
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Kevin M. King @kevinmking.bsky.social · 18/05/2026
Does anyone have examples of successful SHRC Doctoral award applications that they could share with me? We have a Canadian student who is interested in applying for one and we don't have any examples. Thanks in advance!
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Waggoner Lab @labwaggoner.bsky.social · 09/05/2026
Review @natrevimmunol.nature.com @mcgilluniversity.bsky.social Calibrating T cell responsiveness through interactions with self www.nature.com/articles/s41...
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Sherri Christian 🇨🇦 @sherrichristian.bsky.social · 02/05/2026
I am looking for a new investigator who researches #ExtracellularVesicles in #Immunity to suggest as a speaker for next year's Canadian Society for Immunology conference. I am putting together the package for a potential plenary now and need names ASAP! International or Canadian will be considered
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Alejandro Montenegro @aemonten.bsky.social · 27/04/2026
"In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises ∼89,000 high-confidence gene-gene interactions" doi.org/10.1016/j.ce...
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Ariel Levine @ariellevine.bsky.social · 26/04/2026
Anyone know engineering or physics labs/teams in Toronto that would welcome a high school student this summer? My daughter is a rising senior who loves mechanical engineering, fluid dynamics, vehicle dynamics, related fields, and fast cars. We scrambled her plans by deciding to move from DC to 🇨🇦
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Fiona Tribe @fionatribe.bsky.social · 23/04/2026
Yes, Swiss scientist Fritz Zwicky coined the term “dark matter” which is impressive, but he also coined the term “spherical bastard” to describe people who are bastards no matter which way you look at them, and I think that should be celebrated more.
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Johanna Joyce @johannajoyce.bsky.social · 16/04/2026
What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...
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Rosalind & Morris Goodman Cancer Institute @mcgillgci.bsky.social · 20/04/2026
(EN) New review by Daniela Quail and @johannajoyce.bsky.social in @cellpress.bsky.social redefines the tumour microenvironment as a cross-scale ecosystem: www.cell.com/cell/fulltex... (FR) Nouvelle revue par Daniela Quail dans @cellpress.bsky.social redéfinit le microenvironnement tumoral.
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Kurianlab @kurianlab.bsky.social · 17/04/2026
We are looking for a human MALAT1 overexpression plasmid. Does any of you kind people have it?
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Alejandro Montenegro @aemonten.bsky.social · 17/04/2026
I'm looking for #NewPIs (<3 years as lab heads) in the gene regulation/functional genomics space. If you are one or know one, please comment below! 🧪
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Ashwin Varma @ashwinvarma97.bsky.social · 05/04/2026
Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.
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BCCHR ResDev (DM) @resdevbcch.bsky.social · 26/03/2026
@bcchresearch.bsky.social @whrcluster.bsky.social
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Radio-Canada Info @info.radio-canada.ca · 25/03/2026
ici.radio-canada.ca
Le radon : un tueur invisible dans votre maison
Le radon tue 3200 Canadiens chaque année, et pourtant, encore trop peu de personnes s’en préoccupent.
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Nature Biotechnology @natbiotech.nature.com · 19/03/2026
Genome editing’s third act www.nature.com/articles/s41... [🔓read free with login]
nature.com
Genome editing’s third act - Nature Biotechnology
The newest gene editors are shifting away from tackling mutations one by one and toward universal therapies that will hopefully create cheaper and more broadly applicable medicines.
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Turvey Lab @turveylab.bsky.social · 27/02/2026
Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @bcchresearch.bsky.social was able to receive this remarkable curative treatment. Kudos to Dr. Elie Haddad for launching this trial in Canada. @nejm.org @genomecanada.ca @genomebc.bsky.social
hresearch.bsky.social
Bluesky
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Carolina Tropini (TropiniLab@UBC) @ctropini.bsky.social · 13/02/2026
CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46
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Nature @nature.com · 13/02/2026
Nature research paper: SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer go.nature.com/4rOf30b
go.nature.com
SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer - Nature
SLAMF6 functions exclusively as a T cell inhibitory receptor, which is triggered by cis homotypic interactions.
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Nozomu Yachie @nzmyachie.bsky.social · 26/01/2026
Please 🔁 My group at UBC received an allocation from the school to apply for the Canada Impact+ Training Awards (postdoc). Everything is moving fast but please email me in 48 hours with a CV if you are outside Canada and interested😎 Yachie lab: yachie-lab.org sshrc-crsh.canada.ca/en/funding/o...
sshrc-crsh.canada.ca
Canada Impact+ Research Training Awards
The Canada Impact+ Research Training Awards are a one-time initiative designed to recruit international or returning Canadian students and postdoctoral researchers to Canada. These awards support the recruitment of doctoral students and postdoctoral researchers in priority areas, helping build capacity, strengthen the research ecosystem and enhance Canada’s global competitiveness.
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Dylan MacKay @dylanmackayphd.bsky.social · 28/01/2026
Are you a fermentation researcher outside of Canada ? We're looking for a Canada Impact+ Research Chair in Sustainable Food Fermentation Systems. Tenured at Associate or Full Professor. Come join @umanitoba.bsky.social the Harvard of the Prairies ! #share viprecprod.ad.umanitoba.ca/DEFAULT.ASPX...
viprecprod.ad.umanitoba.ca
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Sylvain Baillet @sylvainbaillet.bsky.social · 18/01/2026
🌟🫱🏼‍🫲🏻Join the fun & scientific excellence of Montreal and become a primary partner of Centre de recherche du CHUM (CRCHUM) [please repost]. www.nature.com/naturecareer...
nature.com
Scientific Director - Biomedical Research Institute in Montreal, Canada - Montréal, Quebec (CA) job with Centre d&#39;innovation biomédicale - Université de Montréal | 12851492
The Courtois Institute for Biomedical Innovation (CI²B) is seeking a distinguished scientist to steer its development.
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W. Brent Derry @wbderry.bsky.social · 15/01/2026
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
jobs.utoronto.ca
Assistant Professor - Virology
Assistant Professor - Virology
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BCCHR ResDev (DM) @resdevbcch.bsky.social · 14/01/2026
#CIHR reviewer in training program: apply by Feb 4 to participate in review of Spring 2026 Project grants. See cihr-irsc.gc.ca/e/52291.html...
cihr-irsc.gc.ca
Call for Applications to the Spring 2026 Reviewer in Training Program - CIHR
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Greg Gloor @ggloor.bsky.social · 12/01/2026
Western University is looking for a Canada Research Chair (CRC) Tier 1 in Metabolomics. We are intent on building capacity in this system and the ideal candidate will help build infrastructure and mentor junior faculty. Please see the job ad at: uwo.ca/facultyrelat...
uwo.ca
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Louis-Eric Trudeau @louistrudeau.bsky.social · 07/01/2026
Good news. The government of Canada has recently launched a new initiative to recruit top-level scientists, postdocs and graduate students to Canada. www.canada.ca/en/impact-pl... Please consider joining our neuroscience community at the Université de Montréal!
canada.ca
Canada Impact+ Research Chairs - Canada.ca
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csmb-scbm.bsky.social @csmb-scbm.bsky.social · 07/01/2026
The Department of Molecular and Cellular Biology at the University of Guelph invites applications for a tenure-track position at the rank of Assistant Professor in the area of Cancer Immunology. #JobAlert #ScienceJobs
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Jeremy Snyder @jsnyder.bsky.social · 18/12/2025
@sfu.ca is hiring Canada Impact+ Research Chairs. Research areas include health, including biotechnology; clean technology and resource value chains; environment, climate resilience and the Arctic; democratic and community resilience. Candidates must full Profs or Associate 2 years from promotion.
sfu.ca
Canada Impact+ Research Chairs
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Wyeth Wasserman @wywywa.bsky.social · 18/12/2025
UBC and BC Cancer are recruiting a cancer stem cell faculty member at the Associate Professor or Professor rank for the new Connie Eaves Chair in Cancer Stem Cell Research. A great position recognizing a giant in the field. Please share. #Vancouver ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
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csmb-scbm.bsky.social @csmb-scbm.bsky.social · 16/12/2025
#JobAlert - Canada Research Chair (CRC) – Tier 1 Chair in Metabolomics for Novel Therapeutics at the Schulich School of Medicine & Dentistry at the University of Western Ontario. Info here: csmb-scbm.ca/canada-resea...
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The Viking (Gunnar Blohm) @gunnarblohm.bsky.social · 09/12/2025
📣We have 2 open faculty positions for senior researchers in Neuroscience at Queen's University! healthsci.queensu.ca/administrati... 1. a new Director for our Centre for Neuroscience Studies 2. a non-human primate NeuroAI researcher Please share widely and reach out for questions!
healthsci.queensu.ca
Administrative Opportunities
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FragileNucleosome @fnucleosome.bsky.social · 11/12/2025
🧬🎉Join us on Dec 17th for our last session of 2025! 🎉🧬Two fantastic talks on transcriptional regulation: 🔬JB Lalanne on developmental enhancers (and starting a lab in 2025?) 🔬 @rberrens.bsky.social on transposable elements in development 📋Register here: us06web.zoom.us/webinar/regi...
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Andrew Pruszynski @andpru.bsky.social · 10/12/2025
Great news! We are looking for an NHP neuroscientist as the assistant professor level. We have no preconceived ideas -- looking for the most exciting research going. If you have any questions, please reach out. universityaffairs.ca/search-jobs/...
universityaffairs.ca
Search Jobs - University Affairs
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Saloni @scientificdiscovery.dev · 28/11/2025
“With 3 billion base pairs and nearly 8 billion humans alive today, any mutation that is compatible with life and reproduction likely exists in at least one person’s genome somewhere in the world.” Awesome piece by Veera Rajagopal on how genetics has transformed drug discovery.
worksinprogress.co
Nature’s laboratory - Works in Progress Magazine
Millions of years of evolution have given us genomes that are like giant datasets for drug development. Finally, we are learning how to study them.
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Eran Tal @erantal.bsky.social · 25/11/2025
🚨We're hiring! A tenure track position at McGill University in the area of #bioethics and / or philosophy of science, with a special focus on the ethics of medical technologies. Please share widely. #philsky #ethics #philsci philjobs.org/job/show/30402
philjobs.org
Assistant Professor (Tenure Track), Department of Equity, Ethics, and Policy and Department of Philosophy, McGill University - PhilJobs:JFP Assistant Professor (Tenure Track), Department of Equity...
An international database of jobs for philosophers
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