The Wnt and Hedgehog signaling pathways share mechanistic features and regulatory logic.

Nature Structural & Molecular Biology, Published online: 30 April 2026; doi:10.1038/s41594-026-01800-zThe authors performed computational and experimental analyses to reveal how Smoothened directly inhibits PKA through an intrinsically disordered region, defining a central step in Hedgehog signaling and a mechanism of G-protein-coupled receptor–kinase regulation.

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling, and machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. Humans have 37 E2 ubiq...

A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.