The first chemically fueled small-molecule walker dances around a sugar molecule without falling off

Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on a proteome-wide scale. The strategy relies on the reactivity and specificity of bioor...

Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on proteome-wide scale. The strategy relies on reactivity and specificity of bioorthogon...

In the latest Academic Ranking of World Universities, LMU ranks among the world’s top 50 research-intensive universities.

GR-SCHUHMACHER

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

<div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

YUFE vacancies

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...

We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

YouTube video by chemistry.unwrapped

YUFE vacancies

The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...

We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

Nature Chemical Biology - The field of chemical biology has changed dramatically over the past 20 years. Here, we speak to Sarah E. O’Connor, Benjamin F. Cravatt and Chengqi Yi about the...

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Aryl pinacol boronates generate aryl radicals under aqueous conditions. The formed aryl radicals can be used to functionalize peptide disulfides yielding S-arylated products, but they react readily w...

Principal Scientist - Medicinal Chemistry