Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredi...

Bifunctional diazirine lipids are versatile tools for mapping protein–lipid interactions and cellular localization by photo-cross-linking. Yet, the cross-linking efficiency of these probes has not bee...

Ferroptosis is an Fe2+-dependent and lipid peroxidation-mediated regulated cell death. Its early detection is critical for diagnosis and timely intervention. Lipid hydrogen abstraction is the initiati...

Full time, 2 years fixed term Located at the School of Chemistry on the Camperdown Campus Opportunity to contribute to multidisciplinary research on new mitochondrial targeting agents Base Salary, Lev...

Over the years, I've made a number of graphics highlighting important women in chemistry history. But highlighting and supporting women in chemistry isn't just about pointing to historical figureheads...

Unter dem Motto „Colourful Chemistry” findet vom 10. bis 13. März in Köln das Frühjahrssymposium des JCF (JungesChemieForum) der Gesellschaft Deutscher Chemiker (GDCh) statt. Die Tagung richtet sich a...

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and ...

Using chemical photoswitchable reagents to exert purely wavelength-dependent control over biological systems in deep tissue and in vivo requires a concentration-independent design paradigm. Here, such...

Ideal efficacy photoswitching is introduced as a concept in controlling protein activity with light. Largely independent of the concentration of a light-responsive compound, it enables TRPC4 and TRPC5...

Nature Communications - Enzyme design with non-canonical amino acids has achieved rapid progress in biocatalysis. Here, the authors present an efficient strategy for the design of artificial...

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