A new method to control mRNA activity using bioorthogonal click-to-release reactions is presented. The 5′ cap is modified with a trans-cyclooctene (TCO) that quickly reacts with hydroxyaryl-tetrazine...

This Collection aims to offer insight and inspiration for nucleic acid chemistry, focusing on the structure, function, generation, modification, ...

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The European Research Council (ERC) decision to increase its support for leading researchers moving to Europe has today been formally adopted. On top of its standard grants, the ERC offers additional ...

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...

The biomimetic regeneration system for S-adenosylmethionine (SAM) and SAM analogues presented is based on the salvage of the adenine moiety and in situ supply of d-ribose and polyphosphate. It is com...

LMU researchers have developed a novel cofactor that broadens the use of methyltransferases – with great potential for research and applications.

In nature, many methyltransferases (C1) use S-adenosyl-l-methionine (AdoMet or SAM) as a cofactor for methyl transfer, whereas prenyltransferases (C5) use dimethylallyl diphosphate (DMAPP). We enginee...

RNA modifications are involved in numerous biological processes and vary in different cell types. Methylation is the most widespread type of RNA modification and occurs via S-adenosyl-L-methionine (S...

The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

Translation of mRNA into protein is a fundamental process and tightly controlled during development, however, experimentally controlling the mRNA translation remains challenging. Here, the authors dem...