Check out our new @nature.com paper showing that heme scarcity is surprisingly sensed in #mitochondria by the #DELE1 pathway. Conserved all the way to Hydra, this ancient system takes the heme reading in the very organelle that produces this key metabolite. www.nature.com/articles/s41586-026-10885-x
nature.com
An ancient mitochondrial program tunes translation to haem availability - Nature
An evolutionarily conserved mitochondrial haem-sensing mechanism that predates the emergence of haemoglobin-based oxygen transport could have therapeutic value in iron deficiency disorders.
