Sign in

Kusterlab

@kusterlab.bsky.social
698 followers 111 following 155 posts
PostsRepliesMedia
Kusterlab @kusterlab.bsky.social · 28/09/2026
Hello Singapore! The Kusterlab is happy to be attending #HUPO2026. We have a diverse set of presentations for you that we can't wait to share. We're looking forward to catching up with old friends, meeting new people, and exchanging ideas. See you there!
051
Kusterlab @kusterlab.bsky.social · 23/04/2026
🚨📢 New paper online 🚨📢 Four Xlinking flavors in living cells, up to 1000-fold faster. Highlights include Xlinking kinetics of the RNA-binding proteome and a new way to quantify cytosolic RNA interactions only minutes after ribotoxic stress. #RNASky #Chromatin #Proteomics doi.org/10.1093/nar/...
doi.org
Rapid photo-crosslinking in living cells reveals protein–nucleic acid dynamics on a timescale of minutes
Abstract. The activation of chemical reactions in living cells using ultraviolet (UV) light enables the interrogation of biomolecules in their native envir
0144
Kusterlab @kusterlab.bsky.social · 20/11/2025
New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.
0237
Reposted by Kusterlab
Ludwig Lautenbacher @llautenbacher.bsky.social · 11/11/2025
Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...
nature.com
Koina: Democratizing machine learning for proteomics research - Nature Communications
Koina is an open-source, online platform that simplifies access to machine learning models in proteomics, enabling easier integration into analysis tools and helping researchers adopt and reuse ML mod...
04116
Kusterlab @kusterlab.bsky.social · 09/11/2025
Hello Toronto!🍁The Terrific TUM Team is happy to be attending #HUPO2025. Kusterlab, Wilhelmlab and Leelab have a diverse set of presentations for you that we can't wait to share 🤓. We're excited to spend the next days reuniting with old friends and making new connections. See you there!
0196
Kusterlab @kusterlab.bsky.social · 20/10/2025
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics! We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets. Check it out here: doi.org/10.1002/pmic...
doi.org
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...
02813
Kusterlab @kusterlab.bsky.social · 09/09/2025
New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
doi.org
Peptide-RNA photo-crosslinks with tunable RNA chain map protein-RNA interfaces
Photo-crosslinking mass spectrometry enables the identification of protein-RNA interactions in living cells, pinpointing interaction interfaces at single-amino acid resolution. However, current isolat...
02514
Kusterlab @kusterlab.bsky.social · 25/08/2025
New Preprint: High-intensity 365 nm irradiation accelerates photoreactions in living cells by up to 1000×. We show protein–drug 💊, –protein 💪, –DNA 🧬, –RNA 🧬 crosslinking within seconds, and analysis by #massspec for #proteomics, #chembio, #chromatin and #RNAbiology. www.biorxiv.org/content/10.1...
biorxiv.org
Enhanced photo-crosslinking in living cells with high-intensity longwave ultraviolet light
The activation of chemical reactions in living cells using ultraviolet (UV) light enables the interrogation of biomolecules in their native environment with photoreactive probes or crosslinking reagen...
0165
Kusterlab @kusterlab.bsky.social · 07/08/2025
Thanks @tum.de for highlighting Jakob's recent paper in @cellpress.bsky.social in the university news: www.ls.tum.de/en/ls/public... If you haven't had the chance to read the publication, you can check it out here: doi.org/10.1016/j.ce...
0142
Kusterlab @kusterlab.bsky.social · 31/07/2025
Excited to share our latest work published in #ScienceSignaling! 🚀 www.science.org/doi/10.1126/... (1/4)
science.org
Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling
Proteomic analyses offer insights into how KRAS inhibitors affect oncogenic KRAS signaling.
34112
Kusterlab @kusterlab.bsky.social · 30/07/2025
Kusterlab is looking for a new member to join our Bioinformatics team. Apply now if you're interested in working with us!
021
Kusterlab @kusterlab.bsky.social · 04/06/2025
Another day of #ASMS2025 in Baltimore, and we're back with another poster! Make sure to visit Flo today - he'll present the latest insights from his large-scale decryptM project. Go #TeamMassSpec!
061
Kusterlab @kusterlab.bsky.social · 02/06/2025
Hello Baltimore! We're looking forward to #ASMS2025 and all the new developments in mass-spec and proteomics. If you're attending today, make sure to check out @msleelab.bsky.social's poster on citrullination in multiple sclerosis. Sophia 'Lapo' Laposchan is excited to see you there!
041
Kusterlab @kusterlab.bsky.social · 22/05/2025
🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...
cell.com
The human proteome with direct physical access to DNA
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-aci...
28639
Kusterlab @kusterlab.bsky.social · 09/05/2025
New paper! Our chemoproteomic survey of phenylhydroxamic acids identifies the first drug-like inhibitors for nucleotide-binding protein HINT1 and nucleoside kinases NME1-4. On top, we found probes for the HDAC inhibitor off-target MBLAC2. Check out the open-access article! tinyurl.com/yh92vh6b
tinyurl.com
Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores
Metalloenzyme inhibitors often incorporate a hydroxamic acid moiety to bind the bivalent metal ion cofactor within the enzyme’s active site. Recently, inhibitors of Zn2+-dependent histone deacetylases...
061
Kusterlab @kusterlab.bsky.social · 09/05/2025
New paper! Our chemoproteomic survey of phenylhydroxamic acids identifies the first drug-like inhibitors for nucleotide-binding protein HINT1 and nucleoside kinases NME1-4. On top, we found probes for the HDAC inhibitor off-target MBLAC2. Check out the open-access article! tinyurl.com/yh92vh6b
x.com
sev on X: "Paper alert! We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1. On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor! https://t.co/uuRCO78xFz 👇🧵" / X
Paper alert! We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1. On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor! https://t.co/uuRCO78xFz 👇🧵
064
Kusterlab @kusterlab.bsky.social · 22/04/2025
One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last! With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible. doi.org/10.1038/s41592-025-02663-w #KusterLab #WilhelmLab #MSAID #Proteomics
doi.org
Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods
CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...
0228
Reposted by Kusterlab
Molecular Systems Biology @molsystbiol.org · 12/03/2025
3/2025 Issue ➡️ www.embopress.org/toc/17444292... metabolic mutations drive bacterial antibiotic resistance evolution, prior knowledge for GRN inference, HPA drugs fail mood disorder clinical trials Cover: ATR kinase inhibitors work together to overcome chemoresistance @kusterlab.bsky.social
082
Kusterlab @kusterlab.bsky.social · 04/03/2025
🚀 Exciting news from our lab! Our latest paper has been featured on the cover of @molsystbiol.org - "Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response" by Höfer et al.! 🧬🎉 doi.org/10.1038/s44320-025-00085-6 (1/4)
doi.org
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response | Molecular Systems Biology
imageimagePhosphoproteomics unveils the mode of action of clinical ATR inhibitors and explains their synergy with Gemcitabine in pancreatic cancer cells. Viability screening of 146 targeted drugs ide...
197
Kusterlab @kusterlab.bsky.social · 10/01/2025
🎉 We're happy to announce that our latest project was published in @naturecomms.bsky.social this week: PTMNavigator, a #bioinformatics web platform for in-depth analysis of post-translational modification (PTM) perturbation datasets. 📄 doi.org/10.1038/s414... (1/6)
doi.org
PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways - Nature Communications
Post-translational modifications are important regulators of cellular pathways, but our understanding of these processes is limited. Here, the authors present a web tool that integrates various databa...
1388
Kusterlab @kusterlab.bsky.social · 13/12/2024
(1/5) 🚨 New Research Alert! 🚨 Excited to share our latest work in @embojournal.bsky.social "Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study" ✨ doi.org/10.1038/s443... 📌 Key Highlights:
doi.org
Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study | The EMBO Journal
imageimageFormalin fixed paraffin embedded (FFPE) patient tumor specimens are readily accessible and established gold standard for cancer diagnostics in pathology laboratories. To start building a pan...
2297
Kusterlab @kusterlab.bsky.social · 25/10/2024
That's a wrap on #HUPO2024! Kusterlab, Leelab, Wilhelmlab, and BayBioMS had an awesome time in Dresden. It was good to meet so many familiar and new faces in the community. See you next time! t.co/n306Mxe1fw
020
Kusterlab @kusterlab.bsky.social · 19/10/2024
#HUPO2024 starts tomorrow and the Terrific TUM Team is ready! Kusterlab, Wilhelmlab (@wilhelm_compms), Leelab (@msleemslab) and BayBioMS (@BayBioMS) have printed their posters and prepared their talks, and we're very excited for the next days. See you in Dresden! t.co/RtEIuAOLok
000
Kusterlab @kusterlab.bsky.social · 05/08/2024
Shoutout to our colleagues at @proteomicsdb who are working overtime to solve this!
000
Kusterlab @kusterlab.bsky.social · 05/08/2024
ProteomicsDB has had some downtime lately because of hardware issues. We're sorry for that and promise that it will be up and running again soon! t.co/kN4uJ2gMxA
000
Kusterlab @kusterlab.bsky.social · 11/06/2024
... and it's back: t.co/1tFPnJWsyv
000
Kusterlab @kusterlab.bsky.social · 11/06/2024
Our friends at t.co/1tFPnJWsyv are rolling out an update. Stay tuned for new content and features 👀 t.co/fpp2LUm3NI
000
Kusterlab @kusterlab.bsky.social · 06/06/2024
Final Day of #ASMS2024 in Anaheim, but the Terrific TUM Team is far from done! Ludwig from Wilhelmlab will tell you all about Koina today. And at their posters, meet Flo (Kusterlab), Joel (Wilhelmlab), and Miri (@BayBioMS). See you there! One final time: Go #TeamMassSpec! t.co/yeX48Go2nZ
000
Kusterlab @kusterlab.bsky.social · 04/06/2024
Here's to another day of exciting posters and talks at #ASMS2024! Kusterlab and @msleemslab are looking forward to meeting you! t.co/ls0R8hhQfu
000
Kusterlab @kusterlab.bsky.social · 03/06/2024
You're interested in Computational Mass Spec? We got you covered! Check out our three posters today, presenting the latest updates from SIMSI, Prosit, and Oktoberfest! See you at #ASMS2024! 🧪+💻=😍 t.co/XJfps6pwWT
000
Kusterlab @kusterlab.bsky.social · 02/06/2024
What's up Anaheim! The Terrific TUM Team, aka Kusterlab, Wilhelmlab, and Leelab, is excited for #ASMS2024. Here is our program for the next few days. We hope to meet many of you there and are excited to check out all of your presentations! Let's go #TeamMassSpec t.co/KoI40riq9A
000
Kusterlab @kusterlab.bsky.social · 29/05/2024
Another #decryptM story out! 💪 Congrats to Yun and co-authors! 🥳 Our latest study in @CellReports deciphers KDAC inhibitor action through... (1/2)
000
Kusterlab @kusterlab.bsky.social · 07/05/2024
You can interactively explore the data in the accompanying ShinyApp (t.co/QyYpBtBIDW) as well as on ProteomicsDB (t.co/jUdFpnnbTH) (4/4)
000
Kusterlab @kusterlab.bsky.social · 07/05/2024
We are happy to announce that decryptE is out, another step towards better understanding of drug MoAs. 🎉After elucidating the target space of drugs and how they dose-dependently alter PTMs in cells (decryptM),... (1/4)
000
Kusterlab @kusterlab.bsky.social · 05/04/2024
...and another new Preprint coming right on its heels! This time by Jakob Trendel and colleagues. t.co/EIyIomahOS
000
Kusterlab @kusterlab.bsky.social · 26/03/2024
Check out our new Preprint, authored by @Stefanie_Hoefer et al.! t.co/kWszLj53k1
000
Kusterlab @kusterlab.bsky.social · 13/03/2024
Some impressions from #DGMS2024 Congratulations to the winners of the Wolfgang Paul Study Awards (Sarah Brandtner and @kimgreis), and a big thank you to the @TU_Muenchen helper team! t.co/ODlog91bK2
000
Kusterlab @kusterlab.bsky.social · 12/03/2024
Hello again #DGMS2024! We're ready for the next day of #TeamMassSpec! Today, Cory will show you her work on peptide ID and Quant based only on MS1 spectra 🤯 Later, you can meet and greet no less than 7 of us at their posters. See you there! 👋 t.co/53fp3PYVjg
000
Kusterlab @kusterlab.bsky.social · 11/03/2024
Johanna is about to kick off with her talk about coupling the timsTOF HT with a micro-flow LC. In the afternoon, make sure to check out the posters of Shuyao, Armin, and Andi. See you at #DGMS2024 #TeamMassSpec t.co/uy00m9Qqbr
000
Kusterlab @kusterlab.bsky.social · 16/02/2024
We are happy to see CurveCurator and its "relevance score" highlighted in the bigger picture of omics data analysis. t.co/LxN7ZvvQ4q. Original Article: t.co/PURcSXB1e0 t.co/dXE4BtyrTh
000
Kusterlab @kusterlab.bsky.social · 18/12/2023
And another paper out today - congrats to Chien-Yun (@msleemslab) and Co-Authors 🎉! In their story they shed light on phenotypic drug responses of Sarcoma cells using (phospho)proteomics, leading to some interesting insights into drug MoA. Read all about it in @MolSystBiol! t.co/vBCmC18yfw
000
Kusterlab @kusterlab.bsky.social · 13/12/2023
Thanks @NatureComms for featuring CurveCurator on the Editors' Highlights for "Biotechnology and Methods": t.co/k520oNBUNm 🎉. We are honored! Nice to see that people like the package. 😊 Stay tuned for more dose-response content...
000
Kusterlab @kusterlab.bsky.social · 01/12/2023
CurveCurator fits log-logistic models to data from any kind of dose-dependent assay and provides characteristics such as effect potency, effect size, and statistical significance. (2/3) t.co/88toeadUwn
000
Kusterlab @kusterlab.bsky.social · 01/12/2023
Out today in @NatureComms: CurveCurator, a software to support the analysis of dose-dependent data sets. Congrats to Flo and Co.! 🍾🥳 (1/3) t.co/Q4Fk0ol95q
000
Kusterlab @kusterlab.bsky.social · 20/11/2023
Once again, Bernhard made the list of "Highly Cited Researchers", along with 10 other @TU_Muenchen scientists. We are proud!🥳 Thanks for all the citations and congratulations to all the awesome researchers around the globe that have made the list! 🎉 t.co/GpHqfS1IyK
000
Kusterlab @kusterlab.bsky.social · 02/11/2023
And another paper out today: We congratulate Johanna on her publication in @embojournal! She and her colleagues optimized a workflow for the analysis of brain🧠 tissue from FFPE material. Read all about it here: t.co/uzHHIewsEB
000
Kusterlab @kusterlab.bsky.social · 31/10/2023
Our alumna Maria published her latest research in @nchembio! 🎉 In best #kusterscale fashion she acquired target profiles for over 1000 kinase inhibitors and gained interesting insights, which you can read about here: t.co/qM4dTJOFh6 Congrats to you, Queen of Kinobeads!👑
010
Kusterlab @kusterlab.bsky.social · 21/10/2023
Congratulations🎉 to Severin Lechner (@SevLechner), who has been awarded a prize for his doctoral thesis by the TUM Association of Alumni and Friends!🎓🥳 @medardlab and @kusterlab are proud of you, Sev! 🍾
000
Kusterlab @kusterlab.bsky.social · 20/09/2023
Kusterlab, Leelab (@msleemslab) and BayBioMS (@BayBioMS) had a terrific time at #HUPO2023 in Busan! 😊 See you again next year! t.co/05xIXRQ63k
000
Kusterlab @kusterlab.bsky.social · 18/09/2023
Good morning Busan! Today it is time for @HalitiGenc to present 'The Proteomes that Feed the World'. Also don't miss Chien-Yun (@msleemslab), Giorgi, and Marius at their posters! t.co/m0VLG9KHBt
000