Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...

The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...

Find a PhD Studentship: Regulation of RNA:DNA Hybrid Metabolism for Genome Stability on jobs.ac.uk, the top job board in higher education. Click to view more!

Abstract. Ribosome profiling (Ribo-Seq) has revolutionised our understanding of translation, but the increasing complexity and volume of Ribo-Seq data pres

In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Anti-inflammatory sialylated IgG is enriched in younger people and in mild influenza patients. Chakraborty, Yik-Ling Cheng, Edwards, Gonzalez, et al. define a mechanism by which sialylated IgG induces...

Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of ...

Already Confirmed Speakers:Kirk Brown                        Alnylam Pharmaceuticals, USA

Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …