iiinova — where your digital self keeps evolving

David Monchaud @dmonchaud.bsky.social · 04/09/2026

It was indeed a great pleasure and honor to have all of you in Reading, UK! This second meeting IMAJ#2 marks the second step of a three-step plan: "gather, expand, consolidate". I believe we’ve achieved that goal, and I can’t wait for IMAJ#3!

031

David Monchaud @dmonchaud.bsky.social · 04/09/2026

It was a real pleasure for me to host a panel of researchers whose work I have long admired in Reading UK, for the second International Meeting on Nucleic Acid Junctions IMAJ#2. The idea was to meet, talk, and exchange ideas. The result even exceeded my highest expectations. Can’t wait for IMAJ#3!

010

David Monchaud @dmonchaud.bsky.social · 03/08/2026

We keep on investigating the role(s) of G-quadruplex #G4 in aging and found a quite interesting correlation between age and the level of both G4s and related G4 helicase (particuarly here: DDX3X). With @mcgovernpeds.bsky.social In Cell Death Dis. @springernature.com 👉 doi.org/10.1038/s414...

020

David Monchaud @dmonchaud.bsky.social · 03/08/2026

If you're working with guanine (G)-rich DNA/RNA sequences and want to know whether they fold into G-quadruplex (G4) structures—and which topology they adopt—it can now be done with the naked eye.. or almost! 🔬 Now in @sciencechinapress.bsky.social @springernature.com 👉 doi.org/10.1007/s114...

011

David Monchaud @dmonchaud.bsky.social · 23/05/2026

And many thanks to Juan Carlos for the tour around Granada (and for the famous tapas!) 🇪🇸

020

David Monchaud @dmonchaud.bsky.social · 23/05/2026

I am very happy and honored to have been invited to this wonderful institute. Many thanks to Juan Carlos Morales for the invitation and to all the PIs with whom I had the privilege of exchanging ideas 👍

030

David Monchaud @dmonchaud.bsky.social · 19/05/2026

"A 𝘸𝘦𝘭𝘭-𝘸𝘳𝘪𝘵𝘵𝘦𝘯 𝘢𝘯𝘥 𝘧𝘢𝘴𝘤𝘪𝘯𝘢𝘵𝘪𝘯𝘨 𝘢𝘳𝘵𝘪𝘤𝘭𝘦 𝘢𝘣𝘰𝘶𝘵 𝘵𝘩𝘦 𝘦𝘢𝘳𝘭𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘧 𝘢𝘭𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘷𝘦 𝘋𝘕𝘈 𝘴𝘵𝘳𝘶𝘤𝘵𝘶𝘳𝘦𝘴. 𝘐𝘵'𝘴 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘤𝘰𝘯𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯" I am deeply honored and super proud to receive such feedback from 𝗦𝘁𝗲𝗽𝗵𝗲𝗻 𝗡𝗲𝗶𝗱𝗹𝗲 (UCL London, UK), one of the founding fathers of the field of alternative #DNA structures.

050

David Monchaud @dmonchaud.bsky.social · 19/05/2026

With the goal of further developing our #G4 molecular helicase 𝗣𝗵𝗽𝗖, we—in collaboration with Carla Cruz @ubeirainterior.bsky.social—have investigated the biodistribution of this molecule using gold nanocarriers for controlled release. Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

000

David Monchaud @dmonchaud.bsky.social · 19/05/2026

In Genome Biol. @springernature.com we report on: 1/ the 𝗮𝗻𝘁𝗶𝗰𝗮𝗻𝗰𝗲𝗿 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 of the G-quadruplex #G4 stabilizer 𝗤𝗡-𝟯𝟬𝟮 and a 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗹𝗲𝘁𝗵𝗮𝗹𝗶𝘁𝘆 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝘆 to improve it, and 2/ the genoprotective role of the G4 unwinder 𝗣𝗵𝗽𝗖 With @ucllifesciences.bsky.social & @westernu.ca 👉 doi.org/10.1186/s130...

020

Reposted by David Monchaud

ISI - ICMUB's department of chemistry for health @icmub-isi.bsky.social · 13/05/2026

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Modulating PhpC bioavailability and cellular activity in lung cancer cells via gold nanoparticle functionalization With @ubeirainterior.bsky.social and @westernu.ca Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

041

Reposted by David Monchaud

Nucleic Acids Research @narjournal.bsky.social · 06/05/2026

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

0207

David Monchaud @dmonchaud.bsky.social · 29/04/2026

Happy to take you behind the scenes of the discovery of 7 alternative #DNA structures: 𝘁𝗿𝗶𝗽𝗹𝗲𝘅, G-quadruplex (𝗚𝟰), 𝗶-𝗺𝗼𝘁𝗶𝗳, both 3- and 4-way 𝗗𝗡𝗔 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀, 𝗥-𝗹𝗼𝗼𝗽 and the left-handed duplex 𝗭-𝗗𝗡𝗔. Hope you'll enjoy this journey back in time! In @narjournal.bsky.social 👉 doi.org/10.1093/nar/...

02610

David Monchaud @dmonchaud.bsky.social · 19/03/2026

It was super great to welcome Chun Kit Kwok, from CityUHK, for a 2-day visit in our lab. A very enjoyable time discussing science in general, with of course a deep dive into RNA and G-quadruplex #G4 RNA. Thank you for coming!

020

Reposted by David Monchaud

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 09/02/2026

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC www.biorxiv.org/content/10.64898/20…

042

David Monchaud @dmonchaud.bsky.social · 02/02/2026

Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far? Thrilled to report this long-awaited example with the remediation of industrial wastewater! In @academic.oup.com doi.org/10.1093/nsr/...

040

David Monchaud @dmonchaud.bsky.social · 30/01/2026

FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social 👉 shorturl.at/efE5l

020

David Monchaud @dmonchaud.bsky.social · 16/12/2025

Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay. 4 days, 4 stages, 4 adventures. Thank you Morocco Swim Trek 🙏 👉 moroccoswimtrek.com

030

David Monchaud @dmonchaud.bsky.social · 08/12/2025

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation With Nanjing U & @polytechniqueparis.bsky.social @cnrs.fr In @narjournal.bsky.social: doi.org/10.1093/nar/...

050

David Monchaud @dmonchaud.bsky.social · 29/11/2025

A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!

031

David Monchaud @dmonchaud.bsky.social · 24/11/2025

Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s. The TASQs story: doi.org/10.1021/acs.... This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...

061

David Monchaud @dmonchaud.bsky.social · 03/11/2025

A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner Now in Anal. Chem. @pubs.acs.org With Nanjing U. & @polytechniqueparis.bsky.social @cnrs.fr doi.org/10.1021/acs....

121

David Monchaud @dmonchaud.bsky.social · 03/11/2025

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down) In ACS Bio & Med Chem Au: doi.org/10.1021/acsb... With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)

020

David Monchaud @dmonchaud.bsky.social · 09/10/2025

Stimulating scientific days #ChemBioParis2025. Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com

0102

Reposted by David Monchaud

Michael Booth @drmikebooth.bsky.social · 02/09/2025

We’ve developed the first-ever method to control nucleic acid activity and gene-expressing synthetic cells with a deeply tissue penetrating alternating magnetic field 🧬 🧪 🧲!!! Published in *Nature Chemistry* Led by Ellen Parkes @syncelleu.bsky.social #chemsky www.nature.com/articles/s41...

nature.com

Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells - Nature Chemistry

The programmability of synthetic cells, comprising lipid vesicles that are capable of imitating the structure and function of living cells, facilitates their application as drug delivery devices. Now,...

66215

Reposted by David Monchaud

Hannon research group @hannongroup.bsky.social · 17/09/2025

What happens when a DNA-junction binding compound is lengthened? Intriguingly, the larger pi surfaces widen the range of junctions targeted! Just out in JBIC -congratulations to authors Sam and Hannah -first paper from her MSc by research studies @uobchemistry.bsky.social doi.org/10.1007/s007...

081

David Monchaud @dmonchaud.bsky.social · 28/08/2025

Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4 👉 tinyurl.com/3k6pxu6d (sorry, in French only)

092

David Monchaud @dmonchaud.bsky.social · 27/08/2025

Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices. A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR) Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....

020

David Monchaud @dmonchaud.bsky.social · 26/08/2025

Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC. A collaboration with ITTGN (India) and supported by @embo.org fellowships Now in BMC Biol.: doi.org/10.1186/s129...

051

Reposted by David Monchaud

Di Antonio Research Group @diantoniogroup.bsky.social · 12/07/2025

Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

063

Reposted by David Monchaud

puckknipscheer.bsky.social @puckknipscheer.bsky.social · 13/06/2025

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

science.org

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

67722

David Monchaud @dmonchaud.bsky.social · 20/06/2025

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social ‬ 👉 doi.org/10.1016/j.ij...

090

Reposted by David Monchaud

Vázquez López Lab @biometalusc.bsky.social · 26/05/2025

Call for Expressions of Interest – MSCA Postdocs 2025 Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”. Deadline: June 15 www.usc.es/ciqus/en/MSC... #MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky

001

David Monchaud @dmonchaud.bsky.social · 20/05/2025

The best of the best! The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others Thank you again for your participation!

1102

David Monchaud @dmonchaud.bsky.social · 19/05/2025

It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris. Fantastic talks, lively discussions—and some excellent wine too! 🍷😁 A very promising beginning for this new community Stay tuned—we’ll be back next year! #IMAJ1 #CNRSchimie @cnrs.fr

060

Reposted by David Monchaud

Vázquez López Lab @biometalusc.bsky.social · 16/05/2025

The first IRN on Nucleic Acid Junctions meeting couldn’t have gone any better. Brilliant science, inspiring people, and a perfect atmosphere. Huge thanks to @dmonchaud.bsky.social for making it happen #IMAJ1 #ChemSky #DNAjunctions

031

David Monchaud @dmonchaud.bsky.social · 15/05/2025

Thank you, Miguel! It was great to have you all here in Paris. It was our first meeting, but it was so exciting and promising! I'm eager to repeat this beautiful experience next year, certainly in the UK! Stay tuned! #DNA #DNAjunction #iMAJ #IRN

032

Reposted by David Monchaud

Adam Phillippy @aphillippy.bsky.social · 09/04/2025

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

A phylogeny of the 7 ape genomes that have now been completed from "T2T", with Homer Simpson representing mankind.

515577

Reposted by David Monchaud

Erik Dassi @erikdassi.bsky.social · 09/04/2025

Excited to present our new @naturecomms.bsky.social paper with Stefania Millevoi's lab on the role of #RNA G-quadruplex in mitochondrial RNA. We find that #RG4 can be exploited to inhibit mitochondrial translation and disrupt #cancer cells proliferation. www.nature.com/articles/s41...

nature.com

RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism - Nature Communications

Cancer cells rely on mitochondria for energy and macromolecule synthesis. Here, the authors show that RNA G-quadruplex dynamics, driven by oncogenic signals, regulate the translation of nuclear-encode...

052

David Monchaud @dmonchaud.bsky.social · 07/04/2025

We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate This is huge! 👉 doi.org/10.1038/s414...

091

Reposted by David Monchaud

Schwalbe Lab @schwalbe-lab.bsky.social · 11/03/2025

Have a look at our newest commentary in @pnas.org : "G-quadruplexes and their unexpected ability to fold proteins" Full text: www.pnas.org/doi/10.1073/... #G4 #quadruplex #proteins #folding

pnas.org

G-quadruplexes and their unexpected ability to fold proteins | PNAS

G-quadruplexes and their unexpected ability to fold proteins

0119

Reposted by David Monchaud

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 11/03/2025

In case you missed it, you can now watch the excellent 2025 Francis Crick Lecture from Shankar Balasubramanian on our YouTube channel! Shankar delivered an excellent talk on ‘The DNA Quadruplex Helix’ – it’s not one to miss! youtu.be/RIDAP0Ds2yo

youtu.be

Crick Lecture 2025: The DNA Quadruplex Helix by Shankar Balasubramanian

YouTube video by MRC Laboratory of Molecular Biology

031

David Monchaud @dmonchaud.bsky.social · 11/03/2025

Welcome to BlueSky @jamchemsoc.bsky.social ! Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner #chembio #AcademicSky #SciSky

1133

Reposted by David Monchaud

Bio-protocol @bio-protocol.bsky.social · 11/02/2025

Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells Work by Angélique Pipier and @dmonchaud.bsky.social at ICMUB - Institut de Chimie Moléculaire de l'Université Bourgogne Europe. #LifeSciences #Reproducibility #MolecularBiology

042

David Monchaud @dmonchaud.bsky.social · 22/01/2025

A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social Interested?? All you need is: - the clickable ligand: www.sigmaaldrich.com/FR/en/produc... - and the protocol: doi.org/10.21769/Bio...

2233

David Monchaud @dmonchaud.bsky.social · 15/01/2025

Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ) We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties. 👉 doi.org/10.1002/cmdc...

0111

David Monchaud @dmonchaud.bsky.social · 11/12/2024

A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41... & G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...

3227

Reposted by David Monchaud

John Schneekloth (Jay) @jschneek.bsky.social · 09/12/2024

Really excited to see this work out! In collaboration with Prof. Jen Prescher, we showed that their cyclopropenone labeling strategy can be applied to structured RNA! Thrilled to work with this fantastic team of scientists. pubs.acs.org/doi/10.1021/...

pubs.acs.org

Bioorthogonal Cyclopropenones for Investigating RNA Structure

RNA sequences encode structures that impact protein production and other cellular processes. Misfolded RNAs can also potentiate disease, but a complete picture is lacking. To establish more comprehens...

1236

David Monchaud @dmonchaud.bsky.social · 03/12/2024

One of the ones I am most proud of. In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells. 👉https://dx.doi.org/10.1016/j.jbc.2024.108040 @cnrs.bsky.social

191