Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. H

By Dr. Douglas R. Waverly, Professor Emeritus of Biochemistry, Yale University

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration *Speaker: Hao Hu (Washington University in St. Louis) *Moderator: Jerry Lin (Massachusetts General…

Changes to the Open Science Framework’s policies will come into effect in November, forcing researchers to reconsider their workflows.

Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics

A free browser extension that marks antibodies cited in a paper with their knockout-controlled validation status, for the application they were used in.

Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

The case is the latest example of a scientific workhorse being misused in experiments.

I was recently asked to review a paper that piqued my curiosity. From the abstract it sounded as if it was a secondary analysis of a datas...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH

Interactive Nextflow tutorial: write your first pipeline and run it on real cloud infrastructure, for free and with no installation. Also learn to use existing nf-core pipelines.

As a labor-augmenting technology, large language models (LLMs) have the potential to accelerate scientific activity across the research pipeline. But even if LLMs perform on par with human experts at ...

Created with the Heyzine flipbook maker

There’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Alt...

The defense tech firm's work with public health data has largely flown under the radar.

After several examples of undisclosed alterations in reagent suppliers’ antibody catalogues surfaced, researchers call for transparency to rebuild trust.

Welcome to preLights, the preprint highlights service run by the biological community and supported by The Company of Biologists. Here, a team of scientists regularly review, highlight and comment on ...

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

Nature Medicine - Retraction Note: Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial

Plasmacytoid dendritic cells (pDCs) produce robust type I interferons (IFN-I) within hours of viral sensing, while epithelial cells at mucosal surfaces mount a delayed response dominated by type III i...

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog