Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. H

This link will take you to a page that’s not on LinkedIn

Upstream open reading frames exert translational control of TNFR1, which limits tissue responsiveness to TNF.

Researchers from the LEO Foundation Skin Immunology Research Center (SIC) at the University of Copenhagen have made new insights into the composition of antigen presenting cells in the intestines of p...

Researchers from the LEO Foundation Skin Immunology Research Center (SIC) have made new insights into how Staphylococcus aureus augments skin barrier damage in Cutaneous T cell lym...

Intestinal immune responses must be carefully balanced, as disruptions can lead to conditions such as inflammatory bowel disease. A new study sheds light on how immune cells are organized in the human...

Allergen exposure in wildling mice induces robust de novo responses and activates an endogenous memory TH2 cell pool.

Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure and interactions with commensal and pathogenic microorganisms. In contrast, wild mice encounter diverse microbial environments, undergo natural selection, and rely on robust immune responses for survival. Consequently, lifelong microbial exposure is a key driver in shaping mammalian physiology, establishing the need for naturalizing rodent models in biomedical research. By defining the concepts of ‘microbial self’ and ‘microbial nonself’, we propose a four-step guide for establishing a multigenerational wildling colony that accounts for both microbial self and microbial nonself. This reestablishes the common biological link shared by all free-living mammals, thereby improving the comparability between murine and human studies.

Repeated nickel exposure in individuals allergic to the metal leads to increased clinical reactions. The clinical reactions correlate with an accumulation