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Nico Schramma

@nicoschramma.bsky.social
1.2K followers 1.1K following 71 posts

PostDoc medicalbiochemistry.nl (Amsterdam Medical Center van Buul Lab) Coordinator vascularimmunology.nl PhD Fluidlab.nl Biophysics of Endothelium & Immune cells, Chloroplasts, Bioluminescence, Active Glass tinyurl.com/gscholar-schra nicoschra.github.io

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Reposted by Nico Schramma
Itai Yanai @itaiyanai.bsky.social · 10/10/2026
1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!
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Nico Schramma @nicoschramma.bsky.social · 18/09/2026
😂😂😂
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 18/09/2026
just considering the beat frequency of airway cilia (10-20 Hz), any contrastive timelapse should run on the scale of seconds, in which case basal cell/tissue movement should be imperceptible (minutes to hours)
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Philipp Niethammer @niethammerlab.bsky.social · 04/09/2026
Adaptive motility enables neutrophils to rapidly navigate confined capillaries | Science Immunology www.science.org/doi/10.1126/...
science.org
Adaptive motility enables neutrophils to rapidly navigate confined capillaries
Neutrophils maintain migration speed in confined capillaries through adaptive actomyosin remodeling.
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Mazi Jalaal @mazi1.bsky.social · 05/08/2026
"Odd Droplets: Fluids with Odd Viscosity and Highly Deformable Interfaces,” with Hugo França, now out! We study a new route for controlling interfacial flows using broken symmetries. 🔗 lnkd.in/e_jpUMQt #FluidDynamics #SoftMatter #NonlinearDynamics
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Nico Schramma @nicoschramma.bsky.social · 08/07/2026
A week ago I thought about how to bridge different microscope experiments by using nuclei positions for registration. Then this came out the day later! The BioImageAnalysis community is truly the best :) Thanks for putting out so many great tools to advance research 😊😊😊
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Nico Schramma @nicoschramma.bsky.social · 19/06/2026
I never watched them migrating unfortunately. They were a mixed population - some were transfected successfully and some showed this "astrocytic" phenotype.
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Nico Schramma @nicoschramma.bsky.social · 19/06/2026
Wow I saw something similar once with transfected endothelial cells ! definitely not the desired outcome but cool.
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Society for the Protection of Underground Networks (SPUN) @spun.earth · 11/06/2026
Global topsoil contains ~110 quadrillion km of fungal threads, roughly one billion times the distance from the Earth to the Sun. A new study in @science.org maps this hidden arbuscular mycorrhizal infrastructure for the first time. Explore the Mycorrhizal Infrastructure Map: buff.ly/PISOj8k
a-hidden-infrastructure.spun.earth
A hidden infrastructure
Mapping Earth’s underground mycorrhizal fungal networks — the hidden infrastructure beneath our feet.
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Henry De Belly @henrydebelly.bsky.social · 10/06/2026
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Ben Larson @blarson.bsky.social · 19/05/2026
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Scanning electron microscopy image of the ciliate Euplotes gigatrox on the cover of the journal PNAS. Distinct punk rock vibes
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Gautam Dey @gautamdey.bsky.social · 18/05/2026
Multinucleate cells challenge deeply-held assumptions about complexity, ecological success and evolution. Postdoc extraordinaire and gifted writer @mrosjac.bsky.social tackles this subject with aplomb - tell us what you think! www.sciencedirect.com/science/arti... @currentbiology.bsky.social
sciencedirect.com
Multinucleation as a recurring evolutionary strategy for scaling and plasticity
Multinucleate cells — single cells containing multiple nuclei in a shared cytoplasm — are found across the eukaryotic tree of life. Having evolved ind…
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Alain Goriely @alaingoriely.bsky.social · 15/05/2026
I am looking for a Post-doc in Oxford to work with me on morphogenesis at the cellular scale, with particular emphasis on growth processes and their mechanical and dynamical consequences. Please circulate my.corehr.com/pls/uoxrecru... This bristle is created by a single cell! Let's model it.
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Mary Mirvis @marymirvis.bsky.social · 13/05/2026
1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions? @wallaceucsf.bsky.social www.biorxiv.org/content/10.6...
Images of packed cellular interiors from Maritan et al 2022 and Heinrich et al 2021.
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Yasin Dagdas @plantophagy.bsky.social · 11/05/2026
“In physics, we search for universality,” Jalaal said. “In biology, we embrace non-universality and biodiversity.” www.quantamagazine.org/the-hidden-m...
quantamagazine.org
The Hidden Mathematical Dance Inside Plant Cells | Quanta Magazine
The sunlight-collecting organelles known as chloroplasts solve a packing problem: how to optimize photosynthesis without sustaining damage from dangerously intense rays.
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Plant Science Spotlight @plant-sci.bsky.social · 05/05/2026
Don’t reach for ChatGPT Images or Nano Banana as your first option when creating scientific images There are multiple free and open-source images, icons, and tools for creating scientific illustrations. #plantscience @stephenturner.us blog.stephenturner.us/p/free-open-...
blog.stephenturner.us
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
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Nico Schramma @nicoschramma.bsky.social · 05/05/2026
Our work on chloroplast packing was featured by @quantamagazine.bsky.social in @maxlevy.bsky.social's article. It was a fun colab with @mazi1.bsky.social and Eric Weeks during my PhD that led to this work. Article: www.quantamagazine.org/the-hidden-m... Paper in @pnas.org: doi.org/10.1073/pnas...
share.google
The Hidden Mathematical Dance Inside Plant Cells | Quanta Magazine
The sunlight-collecting organelles known as chloroplasts solve a packing problem: how to optimize photosynthesis without sustaining damage from dangerously intense rays.
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Nico Schramma @nicoschramma.bsky.social · 04/05/2026
Sign up for the Dutch Society for Cell Biology meeting May 21st in Amsterdam dutch-society-cell-biology.nl with speakers: @buzzbaum.bsky.social Lucas Pelkman Geert van den Bogaart @leilaakkari.bsky.social Michiel Pegtel @joachimgoedhart.bsky.social @seemagrewal.bsky.social Martijn Nolte (ZonMW)
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Alfonso Martinez Arias @amartinezarias.bsky.social · 02/05/2026
A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵
cell.com
Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organis...
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Nico Schramma @nicoschramma.bsky.social · 22/04/2026
this looks super useful! congrats :)
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Claire Dessalles @clairedessalles.bsky.social · 22/04/2026
All you ever wanted to know about how to analyse the nematic nature of cellular tissues is right here 👀👇🏼! Bonus #1: we did it for many cell types and uncovered unexpected defect behavior 🐌 Bonus #2: for theoreticians looking for parameter values for your simulation🧑🏼‍💻 tinyurl.com/2s399yen
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Evelyn Strickland @strickland-evelyn.bsky.social · 20/04/2026
What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...
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Joachim Goedhart @joachimgoedhart.bsky.social · 20/04/2026
There's an update of #EZreverse, it is much quicker and supports drag-and-drop joachimgoedhart.github.io/EZreverse.html
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Pau Guillamat @pauguillamat.bsky.social · 16/04/2026
Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Oliver Rocks @oliverrocks.bsky.social · 15/04/2026
Check out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1
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Joachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026
📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...
Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells
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napari @napari.fosstodon.org.ap.brid.gy · 24/03/2026
napari 0.7.0 is available now! 🚀🎉 It's a BIG release so read the full release notes, with highlights: napari.org/stable/release/release_0… We want to thank everyone who has worked incredibly hard on this release including our 11 new brilliant […] [Original post on fosstodon.org]
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Rita Mateus @ritamateus.bsky.social · 05/02/2026
Briefly, after organ injury, 100 milliseconds, we detected collective changes in membrane potential at the tissue level. This is so far the earliest detected wound-response!! This electric signal sparks the formation of a tissue-wide calcium wave👇
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Nico Schramma @nicoschramma.bsky.social · 21/03/2026
So cool! Congrats! 🎉
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Lucien Hinderling @lhinderling.bsky.social · 03/03/2026
PAPER OUT ✨ How can we make smart microscopy more interoperable? What are the technical and cultural challenges? 30+ people from academia and industry propose a roadmap: doi.org/10.1515/mim-... Also a review of applications and repo of implementations. Join the discussion! smartmicroscopy.github.io
Screenshot of the abstract:
Smart microscopy is transforming life sciences by automating experimental imaging workflows and enabling real-time adaptation based on feedback from images and other data streams. This shift increases throughput, improves reproducibility, and expands the functional capabilities of microscopes. However, the current landscape is highly fragmented. Academic researchers often develop custom solutions for specific scientific needs, while industry offerings are typically proprietary and tied to specific hardware. This diversity, while fostering innovation, also creates major challenges in interoperability, reproducibility, and standardization, which slows progress and adaption. This article presents a collaborative effort between academic and industry leaders to survey the current state of smart microscopy, highlight representative implementations, and identify common technical and organizational barriers. We propose a framework for greater interoperability based on shared standards, modular software design, and community-driven development. Our goal is to support collaboration across the field and lay the groundwork for a more connected, reusable, and accessible smart microscopy ecosystem. We conclude with a call to action for researchers, hardware developers, and institutions to join in building an open, interoperable foundation that will unlock the full potential of smart microscopy in life science research.Screenshot of Figure 5: Interoperable smart microscopy ecosystem. Concept of a modular architecture for smart microscopy, where standardized experiment descriptions (e.g. useq-schema) and open data formats (e.g. OME-Zarr) allow integration of diverse microscopes, analysis tools, and user interfaces. Core components such as segmentation [76], [77], tracking [79], [80], and experiment logic are decoupled from specific hardware, enabling reuse across platforms. The system supports multiple input modalities (code, GUI, or natural language) and can be extended with additional devices like fluidics or environmental control modules. This structure enables flexible, feedback-driven acquisition strategies and cross-platform reproducibility.Screenshot of figure 4: Strategies for hardware abstraction that allow smart microscopy workflows to run across different microscope systems, illustrated with example implementations collected on the SMWG website. (A) Software communication layers: Image analysis and experiment logic are implemented in a platform-independent manner, while platform-specific adaptors control acquisition through proprietary microscope software via macros, APIs, or other interfaces. Custom GUIs allow users to configure analysis, while the vendor-provided software manages hardware and acquisition settings. By developing additional adaptors, these workflows can be extended to support microscope systems from other vendors. Example implementation: AutoMicTools , Supplementary Information S3. (B) Device-level standardization (e.g. μManager-based workflows) bypasses proprietary GUIs and provides a unified API for direct device control across manufacturers. This API abstracts vendor-specific differences, enabling consistent control of a growing collection of supported hardware. Example implementation: UU_smart_microscopy , Supplementary Information S2. (C) Event-based standardization decouples experimental design from hardware by describing acquisition events (e.g. acquire frame at x, y, t with channel c) in a structured format (e.g. useq-schema). Control software interprets these definitions and translates them into device-specific commands, enabling the use of vendor-specific features and optimizations during execution. Example implementation: rtm-pymmcore, Supplementary Information S1.
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Andy Moore @aaandmoore.bsky.social · 07/02/2026
Not something you see in textbooks very often: tripolar mitosis.
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epithelial mechanics fan club @epimechfc.bsky.social · 08/02/2026
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells. Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
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Nico Schramma @nicoschramma.bsky.social · 23/01/2026
ow noooo I missed it! :'( will it be made available somewhere online? :)
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Tay (Antonio J. Osuna Mascaró) @biotay.bsky.social · 19/01/2026
Cow Tools! We have lived alongside cows for nearly 10,000 years. We breed them and exploit them It is now, only now, that we have discovered THEY CAN USE TOOLS Here I describe our study (paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social with @auersperga.bsky.social
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Nico Schramma @nicoschramma.bsky.social · 16/12/2025
Congrats this is really cool!!!
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Jean-Yves Tinevez @jytinevez.bsky.social · 20/11/2025
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji. It ships many new features, detailed below, but that are articulated around the following:
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Nico Schramma @nicoschramma.bsky.social · 27/10/2025
Thank you Mathieu :))
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Nico Schramma @nicoschramma.bsky.social · 27/10/2025
Hot out of press!!! Studying chloroplast organisation from the perspective of packing problems in confinement. chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿 www.pnas.org/doi/10.1073/...
pnas.org
Optimal disk packing of chloroplasts in plant cells | PNAS
Photosynthesis is essential for ecosystem survival, but while plants require light, excessive exposure can damage cells. Chloroplasts, photosynthet...
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Joachim Goedhart @joachimgoedhart.bsky.social · 26/10/2025
www.nature.com/articles/d41...
nature.com
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
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Nico Schramma @nicoschramma.bsky.social · 26/10/2025
This is so cool! Congrats! :) Definitely something to try out!
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Nico Schramma @nicoschramma.bsky.social · 07/10/2025
Just won the best poster award for our new work on Chloroplast Packing at the Dutch Biophysics meeting (NWO, BioPM). It was a great collab with Eric Weeks and @mazi1.bsky.social The Paper is also accepted now, so double good news :) Stay tuned!!
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Nico Schramma @nicoschramma.bsky.social · 30/09/2025
Of course!!! :)
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Nico Schramma @nicoschramma.bsky.social · 30/09/2025
The Bioluminescent garment is now in Kunsthal Rotterdam in the big Iris van Herpen exhibition < SCULPTING THE SENSES > www.kunsthal.nl/nl/plan-je-b... Extremely happy to have been there at the premiere and opening! I recommend everyone interested in science or fashion design to visit!! 🩵👗
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Nico Schramma @nicoschramma.bsky.social · 18/09/2025
Thank you so much! 😁😊
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Nico Schramma @nicoschramma.bsky.social · 18/09/2025
Beyond happy! Yesterday I obtained my 🔥PhD🔥 cum laude🔥(highest award) with my work "On Light and Life - Physics of Chloroplast Motion and Bioluminescence"🌿✨ Thanks to so so so many people involved in the work and that have been a huge support to me during this time - especially @mazi1.bsky.social
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Karen Alim @karenalim.bsky.social · 31/08/2025
Join my team for a PhD in Learning in living adaptive networks (Theory). Apply by October 7th through www.portal.graduatecenter.lmu.de/ocgc/qmb
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Steve Haddock @stevehaddock.bsky.social · 28/08/2025
Our science photo book The Radiant Sea is out Sept 2nd!! 30 years of research, 10 years of "we should", and a year of collating pix and writing. Sönke and I show (mostly for the first time) images of how organisms produce, use, and interact with light in the sea. #bioluminescence #fluorescence 🦑🧪🌊
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Nico Schramma @nicoschramma.bsky.social · 22/08/2025
Upcoming Symposium! Physics of Adaptation and Decision making in Biology! When: September 16 Where: Amsterdam, The Netherlands Join us here: www.fluidlab.nl/padm25 Speakers: Ray Goldstein, Sujit Datta, @thomasshimizu.bsky.social, @mirnakramar.bsky.social, @blarson.bsky.social, me
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Talley Lambert @talley.codes · 05/07/2025
it was already fun to look around the documentation for cmap (cmap-docs.readthedocs.io) but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂 as a mild deutan myself, I appreciate it! 🙏
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Lucien Hinderling @lhinderling.bsky.social · 21/08/2025
Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...
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