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Sebastián Palacios Martínez

@spalaciosm.bsky.social
169 followers 232 following 16 posts

PhD at the University of Amsterdam. Microscopy enthusiast 🔬, cytoskeleton admirer 🧫, hopeful sensor builder. Mostly just a biologist finding his way. Opinions my own.

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Reposted by Sebastián Palacios Martínez
Joachim Goedhart @joachimgoedhart.bsky.social · 04/09/2026
Freshly acquired image of a biosensor that is targeted to the endoplasmic reticulum - seems a good fit for #FluorescenceFriday #invertedLUT #inferno
False color image of a HeLa cell showing the endoplasmic reticulum
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Phil Abitua @ohnolog.bsky.social · 30/06/2026
Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil
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Journal of Cell Biology @jcb.org · 19/06/2026
KIF2A stabilizes intercellular bridge #microtubules to maintain mouse embryonic stem cell #cytokinesis. From Lieke Stockmann, Sreya Basu, Niels Galjart and colleagues: rupress.org/jcb/article/... 📕 Part of our #Microtubules collection: rupress.org/jcb/collecti... #EESMicrotubules
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Saravanan Palani @syncellbiolab.bsky.social · 12/06/2026
Our new paper in @plosbiology.org introduces IntAct-U-ExM enabling isoform-specific imaging of actin at nanoscale across yeast, mammalian cells & primary neurons. Fabulous work spearheaded by @anubhavdhar.bsky.social along with an amazing team! #actin #U-ExM journals.plos.org/plosbiology/...
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 12/06/2026
Aren't monolayers fun? I think I have a new desktop background now. #FluorescenceFriday #Microscopy
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MwahahahahahadScientist @mads100tist.bsky.social · 17/04/2026
You know how bakers make croissants? This is like if croissants made bakers
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Joachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026
📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...
Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells
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EMBL @embl.org · 19/02/2026
Our cells are experts at navigating inherently noisy and complicated environments. EMBL researchers are using theoretical physics approaches to uncover fundamental principles behind how cells use complex information to self-organise. www.embl.org/news/science...
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 06/02/2026
Fun with protein isolation beads. #FluorescenceFriday
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Reposted by Sebastián Palacios Martínez
Joachim Goedhart @joachimgoedhart.bsky.social · 27/01/2026
Join us in Amsterdam for a FEBS advanced course on "Functional Imaging of cellular dynamics" from 31st of May - 6th of June 2026 Info: microscopy2026.febsevents.org
Flyer with announcement of the FEBS advanced course in Amsterdam
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Nicolas Minc @minclab.bsky.social · 26/01/2026
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6...
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Fabien Burki @fburki.bsky.social · 21/11/2025
Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky www.nature.com/articles/s41...
nature.com
Rare microbial relict sheds light on an ancient eukaryotic supergroup - Nature
The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups.
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Nature @nature.com · 11/11/2025
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology go.nature.com/4p2hyua
go.nature.com
How genetically encoded sensors have lit up neuroscience
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
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Marija Matejčić (mateytch-itch) @marija-matejcic.bsky.social · 07/11/2025
Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday Part of our TrepatLab preprint: www.biorxiv.org/content/10.1... Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
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Nature @nature.com · 01/11/2025
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government go.nature.com/47hn0n5
go.nature.com
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
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Kelsey Tyssowski @kelseytea.bsky.social · 22/10/2025
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵
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eLife @elife.bsky.social · 22/10/2025
A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates. buff.ly/WHU3w3s
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Taylor Mitchell Brown @tmitchellbrown.bsky.social · 15/10/2025
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby. The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated. #Paleontology #NationalFossilDay 🧪🏺 New at @sciencenews.bsky.social
sciencenews.org
These ancient bumblebees were found with their pollen source
Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 09/10/2025
Can't wait to try this out!
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Reposted by Sebastián Palacios Martínez
Kevin Terretaz @kwolbachia.bsky.social · 04/10/2025
I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
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Nature @nature.com · 02/10/2025
Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91 go.nature.com/46K10ja
go.nature.com
Jane Goodall’s legacy: three ways she changed science
The primatologist challenged what it meant to be a scientist.
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Nick Desnoyer @nickdesnoyer.bsky.social · 01/10/2025
I find that so many biologists are also talented artists. @hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.
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Joachim Goedhart @joachimgoedhart.bsky.social · 29/09/2025
My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it: 🧵
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Tristan Lee @tristanl.ee · 21/08/2025
Screenshot from Fallout: New Vegas showing someone using the C-Finder weapon to focus the power of the sun
https://fallout.fandom.com/wiki/Euclid%27s_C-Finder?file=Euclid.jpg.jpg
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 22/08/2025
Another #FluorescenceFriday, another movie of the cytoskeleton. This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells! LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/
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Michael R Photography 🌿 @msriffle.bsky.social · 07/08/2025
Today is National Lighthouse Day honoring the historical and cultural significance of lighthouses. I've posted this image before but have reprocessed it. It is the lighthouse at St. Marks Florida. #photography #landscape #EastCoastKin #bnw #blackandwhitephotography #infrared #fullspectrum #clouds
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New England Society for Microscopy @nesmicroscopy.bsky.social · 21/07/2025
🐙 This Octopus shifts from deep to active rest while "dreaming" for #MicroscopyMonday. REM‑like sleep (color bursts and twitches) filmed in real time by Horst Obenhaus @octoscience.bsky.social‬, currently a 2025 Whitman Fellow at @mblscience.bsky.social. #NESM #Octopus #Neuro #SleepScience #MBL
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eLife @elife.bsky.social · 01/07/2025
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. buff.ly/pMGXJVM
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025
A very late #FluorescenceFriday. Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025
Shout-out to The Phage Collection Project run by @fnobrega.bsky.social You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance! Check their website for more info ➡️ www.phage-collection.org
phage-collection.org
ThePhageCollectionProject
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 25/06/2025
Proud to work with and learn from an extraordinary biologist 🔬
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Christophe 🔬 Leterrier @christlet.bsky.social · 22/06/2025
Great nod to the photography work of Bernd and Hilla Becher
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Hao Yin @haoyin.bsky.social · 20/06/2025
Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance 😍 Jaap van Buul Lab @jcellsci.bsky.social 2025 journals.biologists.com/jcs/article-...
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Arjun Raj @arjunraj.bsky.social · 20/03/2025
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
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Ankita Jha @ankita13jha.bsky.social · 10/03/2025
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...
biorxiv.org
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
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Joachim Goedhart @joachimgoedhart.bsky.social · 07/03/2025
I had to try this (see preprint), so here's a result with milk ± ampyrone and it just works!!
Image showing that text is occluded by milk, but it the milk is transparent when an absorbing dye (ampyrone) is added.
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 12/02/2025
Does biofluorescence enhance visual signals in birds-of-paradise?: short answer, yes! Birds of paradise show fluorescence in the 520-560nm range. royalsocietypublishing.org/doi/10.1098/...
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Journal of Cell Biology @jcb.org · 24/01/2025
Tubulin arginylation regulates #microtubule dynamics. New study from MacTaggart, @annakashina.bsky.social and colleagues identifies an ATE1-dependent #arginylation site at E77 of α-tubulin and show that this modification regulates the binding of MAP1S to #microtubules. buff.ly/4jqLqhT
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 15/01/2025
Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments by Pasolli et al. Very exciting to see tool development for the less well-studied components of the cytoskeleton. www.biorxiv.org/content/10.1...
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Stephan Huveneers @huveneerslab.bsky.social · 14/01/2025
Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04
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Sebastián Palacios Martínez @spalaciosm.bsky.social · 08/01/2025
And an exciting preprint: Novel Far-Red ERK Biosensors by DeCuzzi et al. (Far-) Red biosensors open many mutliplexing and optogenetic possibilities for studying signaling pathways. www.biorxiv.org/content/10.1...
biorxiv.org
Two Novel Red-FRET ERK Biosensors in the 670-720nm Range
Cell fate decisions are regulated by intricate signaling networks, with Extracellular signal-Regulated Kinase (ERK) being a central regulator. However, ERK is rarely the only signaling pathway involve...
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