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Nick Leigh

@niche-leigh.bsky.social
957 followers 664 following 64 posts

Group Leader at Lund University, Sweden interested in comparative immunology, comparative oncology, and regenerative biology, open and equitable science, and fishing | he/him | leighnd.github.io

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Reposted by Nick Leigh
Claudio Cantù @claudiocantu81.bsky.social · 01/10/2026
CUT&ID does Genomics+Proteomics in one shot via the fusion protein Lazarus Out @narjournal.bsky.social Unstoppable @annanordin.bsky.social is thinker+executor Get in touch if you wish to try it—plasmid soon @addgene.bsky.social 🙏 @liu.se @scilifelab.se @kawresearch.bsky.social @cancerfonden
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Reposted by Nick Leigh
Claudio Cantù @claudiocantu81.bsky.social · 20/09/2026
I will hire a Postdoc to study the genomic determinants of tumor heterogeneity Please, get in touch if interested, or help me spread the voice @scilifelab.se @kawresearch.bsky.social @liu.se liu.se/en/research/...
liu.se
The Cantù Lab - Genome Regulation in Development and Disease
The Cantù Lab at LiU is focused on one important goal: to discover the mechanisms of genome regulation that drive cell differentiation and specialization during embryonic development.
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Nick Leigh @niche-leigh.bsky.social · 28/04/2026
and forgot one of the best parts. Using ShinyCell Emma made the single cell RNA seq data browsable and very interactive. A great resource...check it out! axolotl-limb-regen-scrnaseq.serve.scilifelab.se/app/axolotl-...
axolotl-limb-regen-scrnaseq.serve.scilifelab.se
Single-Cell RNA-seq Time Course of Axolotl Limb Regeneration - Default
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Reposted by Nick Leigh
James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
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Nick Leigh @niche-leigh.bsky.social · 27/04/2026
🐸Do salamanders need adaptive immunity to regenerate limbs and tails? 🐸 Nope! 🚨Check out back-to-back pre-prints from PhD student in our lab Chimezie (tinyurl.com/42wst3bh) and from our collaborators the Max Yun lab (tinyurl.com/b92rzwzr)
illustration by Elsa Pi Börjesson of a salamander surrounding the edges of a white background.
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Reposted by Nick Leigh
Mekayla Storer @storerlab.bsky.social · 10/04/2026
Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...
science.org
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Reposted by Nick Leigh
canaztekin.bsky.social @canaztekin.bsky.social · 10/04/2026
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo
science.org
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
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Reposted by Nick Leigh
bioRxivpreprint @biorxivpreprint.bsky.social · 30/03/2026
Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery www.biorxiv.org/content/10.64898/20…
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Reposted by Nick Leigh
dnarnaresearch.bsky.social @dnarnaresearch.bsky.social · 31/03/2026
Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery doi.org/10.64898/202... DupyliCate - mining, classifying, and characterizing gene duplications doi.org/10.1101/2025... #Genomics #Bioinformatics #Evolution
doi.org
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Reposted by Nick Leigh
bioRxiv Genomics @biorxiv-genomic.bsky.social · 30/03/2026
Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery www.biorxiv.org/content/10.64898/20…
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Reposted by Nick Leigh
phy_papers @phypapers.bsky.social · 01/04/2026
Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery www.biorxiv.org/content/10.64898/20…
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Rajrishi Kumar @rajrishi.bsky.social · 02/04/2026
Sounds interesting!!!
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Reposted by Nick Leigh
Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 02/04/2026
This looks very cool 😎 🔗 to download: github.com/RegenImm-Lab...
github.com
GitHub - RegenImm-Lab/Novabrowse: Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative gen...
Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative genomics tool for multi-species or...
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Nick Leigh @niche-leigh.bsky.social · 02/04/2026
New tool from the lab...check out Novabrowse: An interactive and customizable tool for interpreting BLAST results in genomic context! www.biorxiv.org/content/10.6... Does your favorite gene seems to be missing from your species of interest? Are you sure? 🧵👇 1/n
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Reposted by Nick Leigh
Filipa Simões @simoesfilipa.bsky.social · 23/03/2026
Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6... @idrm.ox.ac.uk @oxforddpag.bsky.social
biorxiv.org
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Reposted by Nick Leigh
Silvia Remeseiro Lab @remeseiro-lab.bsky.social · 11/12/2025
🗓️ 23-26 June 2026 🇸🇪 #PALS #summerschool in #OMICS is back! Soon registration and info about speakers for the 3rd edition! Organized by @claudiocantu81.bsky.social and me, @remeseiro-lab.bsky.social, with the support from @scilifelab.se and @kawresearch.bsky.social
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Reposted by Nick Leigh
Anna Czarkwiani @aniaczark.bsky.social · 05/12/2025
Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄 Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...
science.org
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.
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Nick Leigh @niche-leigh.bsky.social · 08/10/2025
Yesterday @jacoates.bsky.social and I gave talks on pre-prints hosted by the @lunduniversity-med.bsky.social . Jonny gave a great primer on the history of pre-prints and debunked myths about them. I spoke on our experiences with preprints and was encouraged to see this feedback after the talks👇
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Reposted by Nick Leigh
Josh Currie @joshcurrie.bsky.social · 18/09/2025
💥OUR LAB IS HIRING!!💥 We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity. Application link: tinyurl.com/3tpvphpm #SciJob #JobAlert
One of your future coworkers in the Currie Lab, an adorable axolotl.
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Reposted by Nick Leigh
Joan @resabut.bsky.social · 22/07/2025
I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...
doi.org
Decoding sex differences in human immunity through systems immunology
Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se
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Reposted by Nick Leigh
Camila Consiglio @consigliocr.bsky.social · 12/08/2025
‼️Our first review is out‼️ Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments. Excellent work by @resabut.bsky.social & Tianze Cao!
academic.oup.com
Decoding sex differences in human immunity through systems immunology
Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se
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Reposted by Nick Leigh
Filipa Simões @simoesfilipa.bsky.social · 16/05/2025
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
heartdevelopment.org
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
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Reposted by Nick Leigh
Filipa Simões @simoesfilipa.bsky.social · 08/05/2025
Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...
sciencedirect.com
Immune-mediated cardiac development and regeneration
The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…
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Reposted by Nick Leigh
Filipa Simões @simoesfilipa.bsky.social · 02/04/2025
Come and work with us OOH @oxforddpag.bsky.social: ❤️ organoids to study 1) failing hearts and 2) metabolite signalling, with @novonordisk.bsky.social and wonderful colleagues 1) Andrew Lewis & Chris Toepfer @rdmoxford.bsky.social; 2) Yimon Aye @oxfordchemistry.bsky.social. Reach out if interested!
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Reposted by Nick Leigh
Lund Stem Cell Center @lundstem.bsky.social · 21/03/2025
🔬👩‍🔬What sparked your interest in science?👨‍🔬🧫 For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration! 📖 Read more: www.stemcellcenter.lu.se/article/unis...
stemcellcenter.lu.se
UniStem Day 2025: A Decade of Inspiring Future Scientists in Lund
Lund University.
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Nick Leigh @niche-leigh.bsky.social · 21/03/2025
Great write-up from Alexis! UniStem is an amazing initiative and given the current attacks on science it’s critical we work to educate and motivate the future generation to be pro-science.
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Nick Leigh @niche-leigh.bsky.social · 13/02/2025
The newt Pleurodeles waltl has amazing biological features, like the ability to regenerate tail and limbs! Are the secrets to this regenerative capacity in their genome? In this collaborative work from the Leigh, Yun, and Simon labs we explored this question. www.cell.com/cell-genomic... (1/x)
Iberian ribbed newt crawling on a white background
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Reposted by Nick Leigh
Andras Simon @andrassimon.bsky.social · 12/02/2025
A #Pleurodeles on the cover. Interested in this #giantgenome, #salamander #regeneration, #noncodingRNA landscape? Pls check out: www.cell.com/cell-genomic.... Many great labs involved, special thanks to co-senior authors @maxyunlab.bsky.social, and @niche-leigh.bsky.social
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Reposted by Nick Leigh
Murawala Lab at MDI Bio Lab @murawalalab.bsky.social · 30/01/2025
Newt Genome assembly is out. Congratulations @andrassimon.bsky.social @maxyunlab.bsky.social @niche-leigh.bsky.social labs.🍻 www.cell.com/cell-genomic...
cell.com
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration
Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...
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Reposted by Nick Leigh
The Yun Lab @maxyunlab.bsky.social · 30/01/2025
And the newt genome ms is finally out! www.cell.com/cell-genomic... Thanks @andrassimon.bsky.social @niche-leigh.bsky.social labs for an amazing collab, and specially Tom Brown for great assembly skills. @dcgenomecenter.bsky.social @crtd-tud.bsky.social @mpicbg.bsky.social @poldresden.bsky.social
cell.com
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration
Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...
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Reposted by Nick Leigh
Lund Stem Cell Center @lundstem.bsky.social · 27/01/2025
🚀 Lund University's Faculty of Medicine seeks candidates for 2 Assoc. Senior Lecturer roles in: ➡️ Translational research in advanced therapies: buff.ly/4aAb3ci ➡️ Basic research in regenerative medicine & disease mechanisms: buff.ly/3E8BKsl Apply by 10 Feb to join us in Lund!
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Reposted by Nick Leigh
canaztekin.bsky.social @canaztekin.bsky.social · 04/12/2024
Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 www.phd.tuebingen.mpg.de/14722/phdpro... Please RT! 🙌
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Nick Leigh @niche-leigh.bsky.social · 08/01/2025
⚡We are recruiting an Assistant Professor in Regenerative Medicine⚡ Looking for a great place to start a lab? Look no further! The center has a strong track record of developing new PIs and the position comes with substantial 💰. Get in touch if you have questions! lu.varbi.com/en/what:job/...
lu.varbi.com
Associate Senior Lecturer (WCMM Fellow) in Molecular Medicine with a focus on basic research into regenerative medicine and disease mechanisms
In this call for proposals ( Wallenberg Molecular Medicine Fellow ), we are looking for prominent researchers with international research experience. The position is located at the Faculty of Medicine
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Çağrı Çevrim @cagricevrim.bsky.social · 13/11/2024
If you share our enthusiasm for #regeneration, share, follow, and (self-)nominate people to the list. 🧪 go.bsky.app/MGXL9Ra
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Nick Leigh @niche-leigh.bsky.social · 10/06/2024
🐸 Salamanders 🐸 are resistant to cancer! 🚨 5 days🚨 left to apply for a postdoc position to help us discover the origins of this resistance! Come join us!!!
description of postdoc position
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Reposted by Nick Leigh
Tatiana Sandoval Guzmán @tatianasg.bsky.social · 19/02/2024
A new preprint from our lab!
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Nick Leigh @niche-leigh.bsky.social · 15/11/2023
🐸 Salamanders 🐸 are extremely resistant to cancer. Why? We don't know! We have a postdoc position now open to delve into to the tumor resistance mechanisms of salamanders. Big thanks to Cancerfonden for making this possible! Apply now!
postdoc advertisement with Lund stem cell center and salamander logos
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Nick Leigh @niche-leigh.bsky.social · 24/10/2023
Today I went with alumni of the Wallenberg Centre for Molecular Medicine Research School to a nearby English school to share science to 12-13 year olds. The energy and excitement from the both sets of students was amazing!! Hoping we see some of these bright minds in the lab soon!
PhD student presenting for young studentspresenters in front of slide
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Nick Leigh @niche-leigh.bsky.social · 18/10/2023
Happy to be over here...now time to reconnect with all the people who have made the migration over from Twitter. I'll share my thoughts on regeneration, immunology, and using high throughput sequencing in all types of animals!
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