Common Fragile Sites are genomic regions prone to breakage. However, other fragile sites remain underexplored. Here, the authors used single-cell genomics to map replication stress-induced breaks, ide...

Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...

In this ‘Featured resource’ post, we learn about the data and functionalities available at MorphoNet 2.0.

Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

Robin and colleagues describe a population of blood vessel-resident macrophages that function within the vasculature to maintain vascular and blood homeostasis in zebrafish and identify a conserved po...