Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing opposing roles during tumor progression and/or response to ...

Republicans on spending committee push back against proposed reorganization and overhead cuts

Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

The Wistar Institute has an opening for an ambitious and productive Post-Doctoral Fellow to join the laboratory of Dr. Nan Zhang.

IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

An open letter to graduate students and other procrastinators: it's time to write

While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

Mechanisms that differentiate the capacity of newborn immune cells to orchestrate tissue regeneration are inadequately understood. Lantz et al. discover that in response to dying cells, neonatal macro...

Lee et al. show that neutrophil extracellular traps (NETs) establish the pre-metastatic niche in the omentum by recruiting innate-like B cells and eliciting IL-10 production in these cells through ina...

Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

Cancer-associated thrombosis is a leading cause of mortality. Lucotti et al. uncover the formation of a pro-thrombotic niche in the non-metastatic lung microenvironment that promotes thrombosis and me...

IL-27 promotes tumour control by preventing dysfunction and enhancing cytotoxicity of tumour-specific CD8+ T cells.

Researchers have discovered how chemotherapy can change tumours, making them more vulnerable to new types of treatments.

Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

The Wistar Institute Receives Two Biomedical Research Grants from the V Foundation for Cancer Research Press Releases

Murphy and Miyamoto et al. have developed a non-T cell targeting immune therapy for metastatic ovarian cancer. This approach induces tumor regression by ac