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Timothy Hla

@hlatim.bsky.social
608 followers 282 following 117 posts

Scientist, biochemist / molecular biologist, works on lipid mediators, sphingolipids, S1P, prostanoids, vascular biology, endothelial cells, Professor at Harvard Medical School, Boston research.childrenshospital.org/hlal…

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Timothy Hla @hlatim.bsky.social · 02/09/2026
Latest paper from the Hla lab- @elife.bsky.social: Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions doi.org/10.7554/eLif...
doi.org
Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions
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KLAB - finding a cure for GI dysmotility at #HarvardStrong @klab.bsky.social · 09/06/2026
@jasonrkelly.bsky.social interesting post in @bostonglobe.com but I wonder how you are squaring up promoting biotech jobs in Boston with your push for automated labs and AI, which IMHO will reduce the employment footprint. The hand-wavy argument that automation will increase employment wont cut it
bostonglobe.com
Massachusetts built biotech; China is catching up - The Boston Globe
The state can’t afford to lose the state’s signature industry.
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Derek Lowe @dereklowe.bsky.social · 28/05/2026
An unapologetically angry post about what’s being done to US science:
science.org
The Current Crisis: What's Happening to Science in America
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Timothy Hla @hlatim.bsky.social · 28/05/2026
www.vwfb.de Kloster Seeon Angioscience 2026!
vwfb.de
Start
REGISTRATIONS NOW OPEN !
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Timothy Hla @hlatim.bsky.social · 20/05/2026
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature: Cell www.cell.com/cell/fulltex...
cell.com
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...
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Timothy Hla @hlatim.bsky.social · 20/05/2026
This Is Where Elite Schools Went Wrong www.nytimes.com/2026/05/20/o...
nytimes.com
Opinion | A Cattle Ranch Is Doing What the Ivy League Can’t
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Acyn @acyn.bsky.social · 09/05/2026
AOC on possibly running for the Senate or President: They assume my ambition is a title or a seat. My ambition is way bigger than that. My ambition is to change this country. Presidents come and go, elected officials come and go, single payer healthcare is forever.
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Timothy Hla @hlatim.bsky.social · 22/04/2026
Pace of N.I.H. Funding Slows Further in Trump’s Second Year www.nytimes.com/2026/04/22/s...
nytimes.com
Pace of N.I.H. Funding Slows Further in Trump’s Second Year
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Stephan Huveneers @huveneerslab.bsky.social · 21/04/2026
For those interested in endothelial junctions: our latest paper is out in iScience, and it includes a mass spectrometry based VE-cadherin interactome! Turns out that there are many more molecular intractions going on than just with the catenins… See: www.sciencedirect.com/science/arti...
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🇨🇦 l.faraday 🇨🇦 @mizati.bsky.social · 18/04/2026
I think most people would prefer this. #Science
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Richard Sever @richardsever.bsky.social · 11/04/2026
Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...
newsletter.ofthebrave.org
I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.
Attacks on science and immigrants are destroying America.
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Alice Ting @aliceyting.bsky.social · 18/03/2026
Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p
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Timothy Hla @hlatim.bsky.social · 17/03/2026
www.science.org/content/arti...
science.org
Analysis: Why the research money isn’t flowing from NSF and NIH
White House review of agency spending plans for this year is causing delays
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 13/03/2026
we are losing so much talent, progress, and hope for no good reason www.vox.com/future-perfe...
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Timothy Hla @hlatim.bsky.social · 12/03/2026
www.statnews.com/2026/03/12/n...
statnews.com
I’m an NIH whistleblower. The scientific community cannot afford to avoid politics
“Scientists are often encouraged to avoid politics. But this advice is outdated, if it was ever correct in the first place,” writes Jenna Norton, NIH whistleblower.
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Timothy Hla @hlatim.bsky.social · 02/03/2026
What Happened in Chicago When Science Became the Enemy www.nytimes.com/2026/02/23/o...
nytimes.com
Opinion | What Happened in Chicago When Science Became the Enemy
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Timothy Hla @hlatim.bsky.social · 22/02/2026
Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...
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Jim Myers @kidneystories.bsky.social · 22/02/2026
Scientists discover why high altitude protects against diabetes | ScienceDaily - goo.gl/alerts/bjpE31 #GoogleAlerts
goo.gl
Scientists discover why high altitude protects against diabetes
Living at high altitude appears to protect against diabetes, and scientists have finally discovered the reason. When oxygen levels drop, red blood cells switch into a new metabolic mode and absorb lar...
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Timothy Hla @hlatim.bsky.social · 15/02/2026
www.bostonglobe.com/2026/02/09/m...
bostonglobe.com
Boston built a global biotech empire. Now the talent is quietly drifting away. - The Boston Globe
In a first-of-its-kind survey, the Globe asked hundreds of scientists about the impact of federal funding cuts.
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Timothy Hla @hlatim.bsky.social · 14/02/2026
www.science.org/content/arti...
science.org
Another NIH institute loses its director
Health department declines to renew Lindsey Criswell, head of arthritis institute, to another 5-year term
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Nature @nature.com · 13/02/2026
In the shadow of ongoing conflict in Myanmar, physician May T. N. Noe forged a path to achieve her academic goals go.nature.com/4tBFSWO
go.nature.com
‘I was nearly arrested’: escaping Myanmar’s military leadership for a PhD abroad
In the shadow of ongoing conflict, physician May T. N. Noe forged a path to achieve her academic goals.
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Nature @nature.com · 12/02/2026
Newly released files from the investigation of convicted sex offender Jeffrey Epstein reveal that his ties to the scientific community were deeper than previously known go.nature.com/46zpg8k
go.nature.com
Epstein files reveal deeper ties to scientists than previously known
Nature - Latest batch of documents show researchers consulting the financier and sex offender on publications, visas and more.
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Timothy Hla @hlatim.bsky.social · 08/02/2026
Latest preprint from the lab - what does S1P do to neutrophils ? Click the link to find out… www.biorxiv.org/content/10.6...
biorxiv.org
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Timothy Hla @hlatim.bsky.social · 28/01/2026
@raflynn5.bsky.social it’s a pleasure to work with your lab in this exciting discovery- congrats all around!
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Timothy Hla @hlatim.bsky.social · 21/01/2026
www.nytimes.com/interactive/...
nytimes.com
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
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David Ho @davidho.bsky.social · 20/01/2026
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.
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PARCC @parcc-inserm.bsky.social · 10/01/2026
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin. www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Timothy Hla @hlatim.bsky.social · 12/01/2026
Latest collaborative paper with Eric Camerer’s lab out now in @pnas.org - comprehensive analysis of S1PRs and chaperones in the cardiovascular system - www.ncbi.nlm.nih.gov/pubmed/41512...
ncbi.nlm.nih.gov
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice - PubMed
Sphingosine 1-phosphate (S1P) is a bioactive lipid that circulates in plasma bound to high-density lipoproteins (HDL) and albumin. Circulating S1P levels correlate positively with systolic blood pressure (BP) in hypertension and negatively with severity in septic shock and with left ventricular func …
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Hao Yin @haoyin.bsky.social · 09/01/2026
How to build a normal multilayered arterial wall?😎 Activated Sphingosine kinase 1 mediates elastin deficiency-induced arterial hypermuscularization🐭 Both Smooth muscle cell & Endothelial cell contribute @junichisaito.bsky.social @greiflab.bsky.social #NatCVR 2026 www.nature.com/articles/s44...
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samuel mehr @mehr.nz · 10/12/2025
🇨🇦🇨🇦 Just announced: a massive new program from the Canadian govt, separate from the well-known CRCs and CERCs, to recruit foreign scientific talent Canada was already a destination for scientists but whoa. Real impressive for a new govt to back political talking points with serious investment
nouvelles.umontreal.ca
$1.7 billion to attract international researchers to Canada
Details of the major federal initiative to draw new talent to the country's universities were announced today at UdeM.
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NPR @npr.org · 02/12/2025
Young adults who took just a one-week break from social media showed improvement in depression, anxiety and insomnia symptoms, a new study says. Plus, tips for how to take a break from your feed. n.pr/4oN4dWp
n.pr
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Timothy Hla @hlatim.bsky.social · 02/12/2025
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine www.nytimes.com/interactive/...
nytimes.com
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
A quiet policy change means the government is making fewer bets on long-term science.
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Timothy Hla @hlatim.bsky.social · 09/11/2025
A non biologic PCSK9 inhibitor could be a game changer! www.nytimes.com/2025/11/08/h...
nytimes.com
New Pill From Merck Could Slash Cholesterol Levels, Trials Show
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Timothy Hla @hlatim.bsky.social · 02/11/2025
Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity www.cell.com/immunity/ful...
cell.com
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Wang et al. find that cell membrane stress upon viral infection induces expression and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), which, in turn, degrades cGAMP to s...
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Timothy Hla @hlatim.bsky.social · 26/10/2025
New England #foliage #sunsets #TalcottNotch #CT
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Eric Topol @erictopol.bsky.social · 13/10/2025
What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials? open.substack.com/pub/erictopo...
open.substack.com
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
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Science Magazine @science.org · 13/10/2025
Male mice that exercise can pass their newly gained fitness on to male offspring. If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. scim.ag/47igpZm
scim.ag
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
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Journal of Clinical Investigation @jci.org · 10/10/2025
Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie... A. Dushani Ranasinghe & Timothy Hla  Comment on Wenxin Song et al: www.jci.org/articles/vie...
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Nature @nature.com · 01/09/2025
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases go.nature.com/4fYoEwG
go.nature.com
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
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Timothy Hla @hlatim.bsky.social · 01/09/2025
Duh!!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 19/08/2025
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...
nature.com
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 19/08/2025
Very good news and we should all continue to ask our colleagues to come here to Bluesky.
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Timothy Hla @hlatim.bsky.social · 18/08/2025
China’s Biotech Is Cheaper and Faster www.nytimes.com/2025/08/17/o...
nytimes.com
Opinion | China’s Biotech Is Cheaper and Faster
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Timothy Hla @hlatim.bsky.social · 08/08/2025
Excellent review on lipids and CNS neurodegenerative diseases. A neglected area...Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions - Journal of Lipid Research www.jlr.org/article/S002...
jlr.org
Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions
Alzheimer’s disease (AD) presents a significant challenge owing to its widespread prevalence and complex neuropathogenesis, affecting millions worldwide. Current therapeutic strategies that predominan...
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Ivan Zanoni @lozanzi.bsky.social · 06/08/2025
#GlycoPower! @vijayrathinam.bsky.social @raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
nature.com
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
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Timothy Hla @hlatim.bsky.social · 01/08/2025
thehill.com/homenews/sen...
thehill.com
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Nikolai Slavov @slavov-n.bsky.social · 01/08/2025
Senators from both parties endorsed a $400 million increase to the budget of NIH. The Appropriations Committee vote represents a clear opposition of presidential plan to dramatically reduce the support for NIH. www.statnews.com/2025/07/31/n...
statnews.com
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
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Timothy Hla @hlatim.bsky.social · 23/07/2025
www.insidehighered.com/news/faculty...
insidehighered.com
NIH to Limit AI Use, Cap Grant Applications at 6 per Year
The National Institutes of Health says its new policy comes after the agency “recently observed instances of Principal Investigators submitting large numbers of applications.”
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Dr. Ahna Skop @ahnaskop.bsky.social · 16/07/2025
Future of NIH in the hands of five senators. Write to them if you are in PA -McCormick WV - Moore Capito ME - Collins AL - Britt LA - Cassidy
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Timothy Hla @hlatim.bsky.social · 04/07/2025
Latest paper from the lab - CD69 in endothelial cells..Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak - Journal of Biological Chemistry www.jbc.org/article/S002...
jbc.org
Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak
Inflammation disrupts endothelial barrier function and causes vascular leak into the tissue parenchyma. Sphingosine 1-phosphate receptor-1 (S1PR1) in endothelial cells (EC) is a key inducer of endothe...
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