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Andrei Thomas-Tikhonenko

@andrei-thomas-t.bsky.social
110 followers 76 following 10 posts

“There is a crack, a crack in everything | That’s how the light gets in” | @PennMedicine @PennCancer @CHOP_Research @RNASociety

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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 08/08/2025
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
cell.com
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Aberrant splicing of microexons yields non-canonical surface receptors, such as the neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and 19. Sehgal et al. show that Δex5Δ...
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 31/07/2025
This just in… FY’26 Bill Highlights: National Institutes of Health: $48.7 billion for biomedical investments in research. Cancer: $7.4 billion for the National Cancer Institute, including $28 million for the Childhood Cancer STAR Act. www.statnews.com/2025/07/31/n...
statnews.com
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 09/02/2025
I wonder if anyone else was just spending his/her Super Bowl weekend reviewing grants and at ~7 pm of Saturday saw eRA Commons go dark. Not to be paranoid or anything…
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 17/01/2025
A project three years in the making finally sees the light of day. Microexons meet macroglia… cancerous macroglia meet engineered T cells (at your peril). Joint venture with @hagentilgner.bsky.social @yosephbarash.bsky.social et al @childrensphila.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing ev...
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 22/12/2024
This is both public and personal... our latest NIH grant was funded through Gabriella Miller Kids First Research Act... every dollar is re-invested into pediatric cancer research - and real jobs for real people! www.nytimes.com/2024/12/21/u...
nytimes.com
Dropped From Spending Bill, Cancer Research and D.C. Stadium Measures Revived by Senate (Gift Article)
Two bills on pediatric cancer research and a football stadium site had been left out of the main spending package, but passed early Saturday as separate legislation.
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 18/12/2024
Not every week starts on a bad note… TGIM!
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 06/12/2024
One oral and one poster presentations from the ATT lab at #ASH24 in always-sunny San Diego. Cancer immunotherapy through the lenses of RNA metabolism, population genetics, and racial disparities @ash-hematology.bsky.social @pennmedicine.bsky.social
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Andrei Thomas-Tikhonenko @andrei-thomas-t.bsky.social · 22/11/2024
For my first post here, I unveil the just-published definitive version of our NRC Roadmap article, where we argue that “widespread splicing alterations [is a] readily actionable feature of human cancers”. Grateful to Forbeck Foundation for bringing this group together! www.nature.com/articles/s41...
nature.com
Steering research on mRNA splicing in cancer towards clinical translation - Nature Reviews Cancer
Although splicing factors are altered in cancer through mutations and copy number variations, their exact role remains challenging to define. In this Roadmap, Anczukow, Thomas-Tikhonenko and colleague...
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